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Anti-inflammatory and gut modulating effects of donkey whey protein in dextran sodium sulfate-induced colitis mice: Insights from the various processing methods
Publication Year: 2025 Source: J Dairy Sci PMID: 40645491
Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), presents therapeutic challenges due to the limitations and side effects of current treatments, creating a need for safer and more effective alternatives. Despite several studies on the health benefits of donkey milk, its specific impact on UC remains unsolved. This study …
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies
Publication Year: 2025 Source: SLAS Discov PMID: 40645586
Current treatments for inflammatory bowel disease (IBD) are often ineffective long-term, as many patients ultimately become unresponsive to anti-inflammatory drugs. The need for improved therapeutics is urgent. Animal models utilized for drug development are limited by interspecies variability and poor translatability. However, most in vitro models lack the sophistication to …
Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study
Publication Year: 2025 Source: Gut PMID: 40645764
No Abstract
A contributory citizen science project reveals the impact of dietary keys to microbiome health in Spain
Publication Year: 2025 Source: NPJ Biofilms Microbiomes PMID: 40646012
Low consumption of whole grains, fruits, and vegetables has been identified as dietary risks for non-communicable diseases such as inflammatory bowel diseases (IBDs). We explore how individual and lifestyle factors influence these risks by shaping gut microbiome composition. 1001 healthy participants from all Spanish regions provided personal and dietary data …
Interdisciplinary medical education practices: building a case-driven interdisciplinary simulation system based on public datasets
Publication Year: 2025 Source: BMC Med Educ PMID: 40646501
BACKGROUND: Recent advancements in medical education underscore the importance of training professionals who are proficient in multiple disciplines. This study aims to develop clinical data analysis cases centered around diseases by utilizing public datasets, and to investigate the establishment of a "medicine + X" simulation practice system within the framework …
Comorbidities predict institutionalization and mortality in biomarker-confirmed alzheimer's disease
Publication Year: 2025 Source: Alzheimers Res Ther PMID: 40646652
BACKGROUND: We explored the associations of comorbidities with cognitive deterioration, institutionalization, and mortality in biomarker-confirmed Alzheimer's disease (AD) dementia. METHODS: We conducted a Swedish Register-based cohort study consisting of 10,857 people (mean age 74 years) with diagnosed dementia and positive AD biomarkers (CSF Abeta(42)/P-tau(181) ratio). Cognitive function was measured by …
SLAMF7 regulates goblet cell mucus production and negatively impacts gut homeostasis and commensalism
Publication Year: 2025 Source: Gut Microbes PMID: 40646691
Crosstalk between the intestinal mucosal barrier and the gut microbiota contributes to maintaining intestinal homeostasis. Accumulating evidence suggests that diverse mechanisms are involved in maintaining intestinal homeostasis. Any disturbance in these pathways can compromise gut homeostasis and trigger chronic inflammatory diseases such as inflammatory bowel disease (IBD). However, how host …
Millet Quinic Acid Relieves Colitis by Regulating Gut Microbiota and Inhibiting MyD88/NF-κB Signaling Pathway
Publication Year: 2025 Source: Foods PMID: 40647020
Polyphenols are compounds derived from plant-based food possessing numerous biological activities, including inhibiting oxidative stress, suppressing inflammation, and regulating gut microbiota. In this study, we investigated the effects of quinic acid, a phenolic acid from millet, on the regulation of gut microbiota and intestinal inflammation and further discussed the possible …
Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Junctions by Modulating the PPAR-γ/NF-κB Signaling Pathway in Intestinal Cells and Organoids
Publication Year: 2025 Source: Nutrients PMID: 40647158
Background: Intestinal epithelial barrier (IEB) dysfunction is related to multiple gastrointestinal disorders, notably inflammatory bowel disease (IBD). Betulinic acid (BA), a compound derived from birch bark, has demonstrated potential therapeutic benefits in IBD. Nevertheless, the impact of BA on IEB function has not been fully elucidated. Methods: The current study …
Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial-A Pilot Study
Publication Year: 2025 Source: Nutrients PMID: 40647170
Gastrointestinal symptoms, including reflux, bloating, dyspepsia, stomach pain, and altered bowel patterns, are commonly reported in individuals with severe obesity and may significantly impact quality of life. Background/Objectives: Curcumin, a bioactive compound found in turmeric (Curcuma longa L.), possesses anti-inflammatory and antioxidant properties and has been investigated for its potential …
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