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Industrial Bread Composition: Potential Implications for Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Nutrients PMID: 40647225
Background: Ultra-processed food (UPF) intake, particularly that of industrial breads rich in food additives (FAs) like emulsifiers, has been linked to higher risk of inflammatory bowel diseases (IBD). Here, we screened the ingredients and FAs used in the bread industry and reviewed their potential biological effects. Methods: We consecutively screened …
The Role of Vitamin D in Inflammatory Bowel Diseases: From Deficiency to Targeted Therapeutics and Precise Nutrition Strategies
Publication Year: 2025 Source: Nutrients PMID: 40647273
BACKGROUND: Vitamin D plays a crucial role in immune modulation, gut barrier integrity, and inflammation regulation, making it highly relevant in inflammatory bowel disease (IBD). IBD patients often exhibit vitamin D deficiency, which has been linked to increased disease activity, impaired mucosal healing, and a higher risk of complications, including …
Postbiotics Formulation and Therapeutic Effect in Inflammation: A Systematic Review
Publication Year: 2025 Source: Nutrients PMID: 40647290
Background: Postbiotics are bioactive compounds derived from inactivated probiotic microorganisms that show potential for preventing and treating inflammatory diseases. This review aimed to evaluate the evidence on their therapeutic effects in inflammatory conditions. Methods: A search of PubMed, Scopus, and Web of Science databases from 2014 to 2024 identified 39 …
Effects of Lactation Lactoferrin Deficiency on Intestinal Microbiota in Different Mice Models
Publication Year: 2025 Source: Nutrients PMID: 40647352
BACKGROUND/OBJECTIVES: The establishment of early gut microbiota is crucial for host health. Lactoferrin (LF), which is present in breast milk, positively impacts gut microbiota composition. However, the effect of lactation LF on the establishment and composition of early gut microbiota in different disease models in adulthood remains unclear. METHODS: Lactation-LF-deficient …
Navigating Neoplasm Risk in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
Publication Year: 2025 Source: Cancers (Basel) PMID: 40647464
(1) Background and Aims: Patients with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) face a significantly increased risk of malignancies, including a 10-fold higher risk for colorectal cancer (CRC) and a lifetime risk for cholangiocarcinoma (CCA) exceeding 20%. The mechanisms underlying this elevated risk remain elusive. This review …
A Novel Treatment Strategy for Unresectable Locally Recurrent Rectal Cancer-Upfront Carbon-Ion Radiotherapy Followed by Surgical Resection of the Irradiated Intestines
Publication Year: 2025 Source: Cancers (Basel) PMID: 40647528
Background/Objectives: Carbon-ion radiotherapy (CIRT) is a promising treatment option for unresectable locally recurrent rectal cancer (LRRC). However, CIRT is contraindicated in cases where recurrent tumors are attached to the intestine. To address this limitation, we developed a novel treatment strategy involving curative-dose CIRT to recurrent tumors, including the adjacent intestine, …
Work Absenteeism in Inflammatory Bowel Disease Patients Related to Patient-Reported Anxiety Levels and Disease Activity: The IBD-GO-WORK Study
Publication Year: 2025 Source: J Clin Med PMID: 40648783
Background/Objectives: Patients with inflammatory bowel disease (IBD), whether affected by Crohn's disease (CD) or ulcerative colitis (UC), are burdened by disability and a reduced quality of life. The individual's regular participation in daily working life is a key factor among its determinants. This work aims to quantify work absenteeism in …
Efficacy and Safety of Infliximab and Vedolizumab Maintenance Therapy in Patients with Crohn's Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: J Clin Med PMID: 40648793
Background/Objectives: Direct comparative data for infliximab and vedolizumab are limited due to lack of head-to-head trials. This systematic review and meta-analysis compared the efficacy and safety of infliximab and vedolizumab as intravenous or subcutaneous maintenance treatments for adults with moderately to severely active Crohn's disease or ulcerative colitis. Methods: Medical …
Hemorheology in Inflammatory Bowel Disease: A Case-Control Study
Publication Year: 2025 Source: J Clin Med PMID: 40648810
Background: Venous thromboembolism is more prevalent among patients with inflammatory bowel disease (IBD). This study aimed to identify prothrombotic hemorheological alterations in IBD. Methods: We conducted a case-control study with patients with ulcerative colitis, Crohn's disease, and non-IBD control subjects. We measured hemorheological indicators including plasma viscosity (PV), whole blood …
Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients
Publication Year: 2025 Source: J Clin Med PMID: 40648945
Background/Objectives: The prevalence of inflammatory bowel disease (IBD) in spondyloarthritis (SpA) patients is unknown. Our objective was to assess the prevalence of undiagnosed IBD in SpA patients, including those with axial spondylarthritis (axSpA) or psoriatic arthritis (PsA). Additionally, we examined fecal calprotectin (FC) levels in relation to the accuracy of …
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