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Plasma Metabolite Profiles Linked to EAT-Lancet Diet and Risk of Inflammatory Bowel Disease: A Prospective Cohort Study From UK Biobank
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 40223352 DOI: 10.1002/mnfr.70059
The EAT-Lancet Commission recommends a sustainable, health-focused diet, but its impact on inflammatory bowel disease (IBD) and metabolic mechanisms remains unclear. This study explores the association between the EAT-Lancet diet and IBD risk. We included 187 558 participants from the UK Biobank, free from IBD at baseline. Dietary intake was …
Editorial: Real-World Evidence of Upadacitinib-An Effective Induction Therapy for Crohn's Disease?
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40223506 DOI: 10.1111/apt.70113
No Abstract
Identification of Crohn's Disease-Related Biomarkers and Pan-Cancer Analysis Based on Machine Learning
Publication Year: 2025 Source: Mediators Inflamm PMID: 40224483
Background: In recent years, the incidence of Crohn's disease (CD) has shown a significant global increase, with numerous studies demonstrating its correlation with various cancers. This study aims to identify novel biomarkers for diagnosing CD and explore their potential applications in pan-cancer analysis. Methods: Gene expression profiles were retrieved from …
Faecalibacterium prausnitzii Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS-Induced Colitis Mice Model
Publication Year: 2025 Source: Mediators Inflamm PMID: 40224484
Background: Reduction of Faecalibacterium prausnitzii abundance is related to inflammatory bowel diseases (IBDs), and supplement of it exists protective effects. Aim: This study aimed to establish a F. prausnitzii-colonized mouse model and investigate that the presence of F. prausnitzii in the gut can ameliorate the severity of dextran sulfate sodium …
Deciphering the Interplay Among Inflammatory Bowel Disease, Gut Microbiota, and Inflammatory Biomarkers in the Risk of Colorectal Cancer
Publication Year: 2025 Source: Mediators Inflamm PMID: 40224486 DOI: 10.1155/mi/4967641
Background: Patients with inflammatory bowel disease (IBD) have an elevated colorectal cancer (CRC) risk, though the etiology remains unclear. This study aimed to elucidate the interplay among IBD, gut microbiota (GM), inflammatory biomarkers, and CRC risk. Methods: First, we employed cohort analysis using the UK Biobank (UKB), linkage disequilibrium score …
Unveiling the Role of GRK2: From Immune Regulation to Cancer Therapeutics
Publication Year: 2025 Source: Mediators Inflamm PMID: 40224487 DOI: 10.1155/mi/8837640
G protein-coupled receptors (GPCRs) represent humans' most prominent family of membrane proteins. In contrast, G protein-coupled receptor kinases (GRKs) play a pivotal role in the rapid desensitization of GPCRs. GRK2 is a particularly significant member of the GRK family. Recent studies have demonstrated that GRK2 primarily regulates immune cell function …
A multivariable prediction model to stratify risk of 90-day rehospitalization among adults with ulcerative colitis
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 40224574
BACKGROUND: Individuals with ulcerative colitis (UC) are frequently re-hospitalized for persistent or recurrent severe disease flares. Accurate prediction of the risk of early re-hospitalization at the time of discharge could promote targeted outpatient interventions to reduce this risk. METHODS: We conducted a retrospective study in adults with UC admitted to …
Lack of sex bias in the referral letters for patients with inflammatory bowel disease: a mixed methods evaluation
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 40224575 DOI: 10.1093/jcag/gwae056
No Abstract
The emerging role of honeysuckle flower in inflammatory bowel disease
Publication Year: 2025 Source: Front Nutr PMID: 40225345 DOI: 10.3389/fnut.2025.1525675
Crohn's disease (CD) and ulcerative colitis (UC), referred to as inflammatory bowel disease (IBD), pose considerable challenges in treatment because they are chronic conditions that easily relapse. The occurrence of IBD continues to rise in developing countries. Nonetheless, the existing therapies for IBD have limitations and fail to address the …
Bayesian Generalized Linear Models for Analyzing Compositional and Sub-Compositional Microbiome Data via EM Algorithm
Publication Year: 2025 Source: Stat Med PMID: 40227158 DOI: 10.1002/sim.70084
The study of compositional microbiome data is critical for exploring the functional roles of microbial communities in human health and disease. Recent advances have shifted from traditional log-ratio transformations of compositional covariates to zero constraint on the sum of the corresponding coefficients. Various approaches, including penalized regression and Markov Chain …
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