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Assembly of MSCs into a spheroid configuration increases poly(I:C)-mediated TLR3 activation and the immunomodulatory potential of MSCs for alleviating murine colitis
Publication Year: 2025 Source: Stem Cell Res Ther PMID: 40221757 DOI: 10.1186/s13287-025-04297-3
BACKGROUND: Inflammatory bowel disease (IBD) is associated with significant clinical challenges due to the limitations of current therapeutic approaches. Mesenchymal stem cell (MSC)-based therapies have shown promise in alleviating IBD owing to their potent immunomodulatory properties. However, the therapeutic efficacy of these cells remains suboptimal, primarily due to the harsh …
Spatial distribution of acute myeloid leukaemia in Denmark
Publication Year: 2025 Source: Environ Health PMID: 40221791
BACKGROUND: Although various occupational and environmental exposures are suspected risk factors for acute myeloid leukaemia (AML), the aetiology of AML is largely unknown. We present an analysis of the spatial distribution of AML in Denmark on an unprecedented, detailed scale. Such investigations have the potential to uncover geographical areas of …
Anti-inflammatory and antioxidant effects of haematococcus carbon dots in ulcerative colitis: A nanoparticle-based approach
Publication Year: 2025 Source: J Biomater Appl PMID: 40221894 DOI: 10.1177/08853282251333240
Ulcerative colitis (UC) is a chronic, non-specific inflammatory disease affecting the colon and rectum, classified as a type of inflammatory bowel disease (IBD). This study aimed to evaluate the therapeutic effects of Haematococcus carbon dots (HP-CDs) on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. HP-CDs were synthesized from Haematococcus …
Crohn's Disease‒Associated Escherichia coli BasRS Is Involved in Fimbriae Expression, Contributing to Epithelial Cell Invasion
Publication Year: 2025 Source: Microbiol Immunol PMID: 40221934
Crohn's disease‒associated adherent-invasive Escherichia coli (AIEC) colonizes the gut lumen through Type 1 fimbriae. We demonstrated that the two-component signal transduction system BasRS is involved in the expression of fimbriae in the AIEC strain LF82, as evidenced by the reduced transcriptional activity of fimA in an LF82 mutant lacking BasRS. …
[Amyloid goiter in the materials of our surgical department]
Publication Year: 2025 Source: Orv Hetil PMID: 40222002
Introduction: In surgical departments where a sufficient number of thyroid surgeries are performed, relatively rare histopathological diagnoses may also be encountered. Knowledge of these histopathological diagnoses is essential for understanding the etiology and selecting the appropriate treatment for the disease. Objective: We aimed to determine the prevalence of amyloid goiter …
Safety Outcomes in Patients With Ulcerative Colitis Using a Healthcare Administrative Database in the United States
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40222016
INTRODUCTION: Several therapies, including sphingosine 1-phosphate receptor modulators, have been approved for ulcerative colitis (UC). Safety findings should be complemented with real-world data (RWD) as rare events may be underestimated in clinical trials due to populations not fully reflecting real-world practice. METHODS: We used RWD to investigate safety outcomes in …
A Multicenter Study to Assess Avoidant/Restrictive Food Intake Disorder in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40222035 DOI: 10.1093/ibd/izaf016
BACKGROUND AND AIMS: Disordered eating is frequently reported in patients with inflammatory bowel disease (IBD). We aimed to describe the prevalence of avoidant restrictive food intake disorder (ARFID) in patients with IBD and to identify predictors of ARFID. METHODS: Patients with IBD at 2 academic medical centers completed questionnaires including …
Alterations in Pain Perception in Inflammatory Bowel Disease Patients with Psychiatric Comorbidity
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40222036
No Abstract
Comprehensive analysis of faecal metagenomic and serum metabolism revealed the role of gut microbes and related metabolites in detecting colorectal lateral spreading tumours
Publication Year: 2025 Source: Virulence PMID: 40223231 DOI: 10.1080/21505594.2025.2489154
Colorectal lateral spreading tumours (LST), early-stage lesions of colorectal cancer (CRC), are associated with gut microbiota dysbiosis. However, the functional alterations in gut microbiota and their metabolic pathways remain inadequately understood. This study employed propensity score matching to compare 35 LST patients with 35 healthy controls. Metagenomic and metabolomic analyses …
Curious case of severe scurvy
Publication Year: 2025 Source: Nutr Clin Pract PMID: 40223322
Scurvy, the clinical manifestation of vitamin C deficiency, exhibits the characteristic cutaneous findings of perifollicular petechiae, corkscrew hairs, gingivitis, swollen gums, and easy bruising. Syncope is a less reported presenting symptom. Although considered a rare nutritional deficiency not commonly seen in the developed world, it should remain on the differential …
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