Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Efficacy and safety of intravenous vedolizumab treatment in Chinese patients with moderate-to-severe Crohn's disease
Publication Year: 2025 Source: Clin Res Hepatol Gastroenterol PMID: 40228712
BACKGROUND & AIMS: Vedolizumab is a gut-selective monoclonal anti-alpha(4)beta(7) integrin antibody treatment for Crohn's disease (CD). A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial (NCT03234907) assessed vedolizumab efficacy and safety in Chinese patients with moderate-to-severe CD and inadequate/loss of response/intolerance to previous conventional or anti-tumor necrosis factor-alpha therapy. METHODS: Eligible …
Emerging Co-infection of avian adenovirus and astrovirus in Lebanese poultry
Publication Year: 2025 Source: Microb Pathog PMID: 40228748 DOI: 10.1016/j.micpath.2025.107581
In the spring of 2023, several "broiler breeder" and "broiler" farms in North Lebanon were affected by a disease that impaired general performance and caused severe daily mortalities. Despite antibiotic treatments, there was no significant improvement. Serological analysis indicated that the flocks were protected against Infectious Bursal Disease (IBD), Infectious …
Metagenomic source tracking after microbiota transplant therapy
Publication Year: 2025 Source: Gut Microbes PMID: 40229213
Reliable engraftment assessment of donor microbial communities and individual strains is an essential component of characterizing the pharmacokinetics of microbiota transplant therapies (MTTs). Recent methods for measuring donor engraftment use whole-genome sequencing and reference databases or metagenome-assembled genomes (MAGs) to track individual bacterial strains but lack the ability to disambiguate …
The impact of inflammatory bowel disease on dementia risk: a current systematic review and meta-analysis
Publication Year: 2025 Source: Sci Rep PMID: 40229330 DOI: 10.1038/s41598-025-96331-w
Emerging evidence indicates that inflammatory bowel disease (IBD) and dementia may share underlying pathological mechanisms and risk factors. However, the association between a prior IBD diagnosis and the subsequent risk of dementia remains largely unexplored. We conducted a comprehensive search of PubMed, Embase, and the Cochrane Library up to February …
Association of regional adiposity distribution with risk of autoimmune diseases
Publication Year: 2025 Source: Clin Rheumatol PMID: 40229502 DOI: 10.1007/s10067-025-07426-8
OBJECTIVE: To detect the association between regional adiposity distribution and the incidence of seven autoimmune diseases (ADs) in UK Biobank cohort and Mendelian randomization (MR) analyses. METHODS: We used Cox models to evaluate the associations between seven adiposity distribution measures and seven ADs (systemic lupus erythematosus [SLE], seropositive rheumatoid arthritis …
Investigation and Analysis of Frailty and Nutritional Status in Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40230499 DOI: 10.1093/crocol/otaf010
BACKGROUND: To analyze the current status of frailty and the primary factors influencing frailty in patients with inflammatory bowel disease (IBD). METHODS: We conducted a study using a fixed-point consecutive sampling method to investigate hospitalized patients with IBD aged 18 years or older in the Gastroenterology Department of a general …
Differences in colonoscopy performance among four endoscopy centers in Western Norway: Influence of case-mix
Publication Year: 2025 Source: Endosc Int Open PMID: 40230559 DOI: 10.1055/a-2546-9515
BACKGROUND AND STUDY AIMS: Unmodifiable patient factors such as age, sex, and indication (case-mix) may influence colonoscopy performance. In this study, we explored how case-mix affected polyp detection, cecal intubation, and pain on a center level. METHODS: A cross-sectional study was performed on data from four centers in Western Norway …
Diagnosis of small bowel inflammation using small bowel capsule endoscopy combined with abdominal CT scan
Publication Year: 2025 Source: Endosc Int Open PMID: 40230560
BACKGROUND AND STUDY AIMS: Abdominal computed tomography (CT) scans are simple to perform and widely used in evaluating small bowel inflammation. However, detailed evaluation of small intestinal mucosa is difficult with CT. Conversely, small bowel capsule endoscopy (SBCE) is noninvasive and useful for evaluation of mucosal inflammation. We evaluated presence …
A cerium nanocluster for effective alleviation of inflammatory bowel disease by scavenging RONS and regulating gut microbiome
Publication Year: 2025 Source: Mater Today Bio PMID: 40230644 DOI: 10.1016/j.mtbio.2025.101705
Inflammatory bowel disease (IBD) is characterized by excessive generation of reactive oxygen species and reactive nitrogen species (RONS) within the pro-inflammatory microenvironment. Conventional treatments often have serious side effects, making IBD management challenging. Here, a new cerium cluster, Ce12, with a formula of [Ce(12)(mu (3)-O)(8)(mu (3)-OH)(8)(mu (2)-OH)(6)(ADA)(18)]∙3H(2)O∙3CH(3)CN (ADA(-) = 1-adamantanecarboxylate) …
IFN-γ-Induced intestinal epithelial cell-type-specific programmed cell death: PANoptosis and its modulation in Crohn's disease
Publication Year: 2025 Source: Front Immunol PMID: 40230837 DOI: 10.3389/fimmu.2025.1523984
BACKGROUND: Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) and is considered a Th1-mediated disease, supported by the over-expression of interferon-gamma (IFN-gamma) in the intestinal lamina propria. IFN-gamma has a pleiotropic effect on the intestinal epithelial cells (IECs), suggesting that IFN-gamma-induced responses may differ between epithelial cell types. …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide