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Adverse events of concomitant use of immune checkpoint inhibitors and metformin or statin: an observational, retrospective disproportionality analysis
Publication Year: 2025 Source: Expert Opin Drug Saf PMID: 40232293
BACKGROUND: Preclinical investigations have indicated that the concurrent administration of ICIs with statins or metformin may enhance the anticancer properties. Nevertheless, the patterns of potential toxicity associated with this combination have yet to be elucidated. RESEARCH DESIGN AND METHODS: We utilized the Food and Drug Administration Adverse Event Reporting System …
Current practice and innovations in diagnosing perianal fistulizing Crohn's disease (pfCD): a narrative review
Publication Year: 2025 Source: Tech Coloproctol PMID: 40232330
Perianal fistulizing Crohn's disease (pfCD) represents a severe manifestation of Crohn's disease (CD) that often leads to significant morbidity. Clinical examination alone of perianal fistulae is unlikely to be sufficient in the context of complex pfCD, as patients are likely to have complex disease and are more likely to experience …
Quantitative MRI radiomics approach for evaluating muscular alteration in Crohn disease: development of a machine learning-nomogram composite diagnostic tool
Publication Year: 2025 Source: Abdom Radiol (NY) PMID: 40232416
BACKGROUND: Emerging evidence underscores smooth muscle hyperplasia and hypertrophy, rather than fibrosis, as the defining characteristics of fibrostenotic lesions in Crohn disease (CD). However, non-invasive methods for quantifying these muscular changes have yet to be fully explored. AIMS: To explore the application value of radiomics based on magnetic resonance imaging …
Musculoskeletal Symptoms and Clinical Findings in Bio-naïve Patients with Inflammatory Bowel Disease Prior to Biological Treatment Initiation: A Prospective Cohort Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40232572 DOI: 10.1007/s10620-025-09016-9
BACKGROUND: Musculoskeletal involvement in inflammatory bowel disease (IBD) patients contributes to poorer outcomes and reduced quality of life (QoL). We aimed to describe the prevalence and distribution of peripheral and axial musculoskeletal symptoms and clinical findings in patients with IBD prior to biological treatment. METHODS: Bio-naive patients with IBD were …
Hematopoietic stem cell transplantation in Crohn's disease: a comprehensive review
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 40232992
PURPOSE OF REVIEW: Despite advances in medical therapies for the treatment of Crohn's disease (CD), 20-30% of patients fail to respond to these therapies (i.e. refractory CD). Medically refractory CD leads to significant disability increasing morbidity and mortality. To prevent the disability of refractory CD, hematopoietic stem cell transplantation (SCT) …
Orally-deliverable liposome-microgel complexes dynamically remodel intestinal environment to enhance probiotic ulcerative colitis therapy via TLR4 inhibition and tryptophan metabolic crosstalk
Publication Year: 2025 Source: Biomaterials PMID: 40233710
Probiotics emerges as a promising option for ulcerative colitis (UC) treatment, but its application remains challenging due to insufficient colon-targeted delivery efficiency and survival against the inflammation-associated intestinal oxidative stress. To address these issues, here we report a supramolecular liposome-microgel complex (SLMC) incorporated with Bacillus subtilis spores (BSSs) and dexamethasone …
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Publication Year: 2025 Source: Immunity PMID: 40233759
Prolonged exposure to a high-fat diet (HFD) exacerbates intestinal disease pathology, yet the early events preceding the development of gut inflammation remain poorly understood. Here, we show that within 48 h, HFD impairs intestinal group 3 innate lymphoid cells (ILC3s) and their capacity to produce interleukin-22 (IL-22), critical for maintaining …
Preparation of gastrointestinal pH-responsive zein coated tea polyphenol-heparin hydrocolloids using for inflammatory bowel disease therapy
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40233898 DOI: 10.1016/j.ijbiomac.2025.143135
In the pathogenesis of inflammatory bowel disease (IBD), overstimulation of inflammatory factors can trigger a coagulation cascade, increase the risk of intestinal micro-thrombosis and lead to microcirculation disorders. However, prevention of microcirculation pathways has not received enough attention. Heparin is commonly used in anticoagulant therapy, but oral delivery does not …
Gastrointestinal Behҫet's disease mimicking appendicitis
Publication Year: 2025 Source: BMJ Case Rep PMID: 40234076
A woman in her 40s of Chinese and African American ancestry with medical history of severe Behҫet's disease on immunosuppressive therapy presented with right lower quadrant abdominal pain. CT of the abdomen and pelvis suggested appendicitis. General surgery recommended bowel rest and antibiotics for treatment, considering her a high surgical …
Bowel urgency in ulcerative colitis assessed from patients' reports: Results of a telemonitoring programme
Publication Year: 2025 Source: Dig Liver Dis PMID: 40234158 DOI: 10.1016/j.dld.2025.03.019
BACKGROUND: Bowel urgency is common in ulcerative colitis (UC), but which patients are affected, and how, has not been fully studied. OBJECTIVE: We explored associations of bowel urgency with the clinical characteristics of unselected outpatients. DESIGN: The study included adults with UC already enrolled in a telemonitoring programme using the …
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