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Network analysis of extraintestinal manifestations and associated autoimmune disorders in Crohn's disease and ulcerative colitis
Publication Year: 2025 Source: NPJ Digit Med PMID: 40234671 DOI: 10.1038/s41746-025-01504-6
We detect and interactively visualize occurrence, frequency, sequence, and clustering of extraintestinal manifestations (EIM) and associated immune disorders (AID) in 30,334 inflammatory bowel disease (IBD) patients (Crohn's disease (CD) n = 15924, ulcerative colitis (UC) n = 11718, IBD unclassified, IBD-U n = 2692, 52% female, median age 40 years …
Spontaneous ileitis and postsurgical murine models of enteric hyperoxaluria
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40235154
Enteric hyperoxaluria, a risk factor for kidney stone disease, often arises from malabsorptive bariatric surgeries or inflammatory bowel diseases. Current murine models for studying this condition are limited, necessitating new approaches. This study aims to establish two novel and distinct mouse models to investigate enteric hyperoxaluria: one simulating Roux-en-Y gastric …
Inflammatory bowel disease therapeutics: a bibliometric analysis of tofacitinib research in ulcerative colitis
Publication Year: 2025 Source: Front Pharmacol PMID: 40235538
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting millions worldwide. Tofacitinib, an inhibitor of Janus kinase (JAK), has shown considerable potential as an effective treatment option for individuals suffering from moderate to severe UC, aiming to mitigate the risk of colectomy, hospitalization, and disease exacerbation. METHODS: We …
Artificial intelligence-assisted capsule endoscopy for detecting lesions in Crohn's disease: a systematic review and meta-analysis
Publication Year: 2025 Source: Front Artif Intell PMID: 40235858
BACKGROUND AND OBJECTIVES: Crohn's disease (CD), a complex member of the inflammatory bowel disease spectrum, is characterized by the diversity and skipping distribution of intestinal mucosal lesions, significantly complicating its differential diagnosis with intestinal diseases such as ulcerative colitis and intestinal tuberculosis. With the increasing application of artificial intelligence (AI) …
Intestinal obstruction caused by early stage primary ileum adenocarcinoma: A case report and review of literature
Publication Year: 2025 Source: World J Gastrointest Oncol PMID: 40235870
BACKGROUND: Ileum adenocarcinoma (IA), a type of small bowel adenocarcinoma, is a rather uncommon factor associated with obstruction in small bowel. Owing to its location and indefinite clinical symptoms, the diagnosis of IA is difficult, and survival is usually poor. With respect to the rarity of this disease, very few …
Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort
Publication Year: 2025 Source: bioRxiv PMID: 40236053 DOI: 10.1101/2025.04.02.646850
No Abstract
Beyond the Usual Age: A Case Report on Segmental Colitis Associated With Diverticulitis in a Young Patient
Publication Year: 2025 Source: Cureus PMID: 40236347
Diverticulitis is a common condition generally seen in older populations. It is rare, but not impossible, to see in younger patients where it can often be confused with other abdominal pathologies. Segmental colitis associated with diverticulitis (SCAD) had been previously considered a complication of diverticulitis, and only fairly recently has …
Tauroursodeoxycholic Acid (TUDCA) Reduces ER Stress and Lessens Disease Activity in Ulcerative Colitis
Publication Year: 2025 Source: medRxiv PMID: 40236400
BACKGROUND AND AIMS: In inflammatory bowel disease, protein misfolding in the endoplasmic reticulum (ER) potentiates epithelial barrier dysfunction and impairs mucosal healing. Tauroursodeoxycholic acid (TUDCA), a naturally occurring bile acid, acts as a chemical chaperone to reduce protein aggregation and colitis severity in preclinical models. We conducted an open label …
Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders
Publication Year: 2025 Source: ACS Med Chem Lett PMID: 40236523 DOI: 10.1021/acsmedchemlett.5c00135
This patent application illustrates a series of cyclic peptides inhibiting Interleukin-23 (IL-23), as represented by Formula I. These cyclic peptides exhibit significant therapeutic potential for treating diseases and disorders associated with IL-23 imbalance, with a particular focus on inflammatory bowel disease (IBD).
Clinical trials and young adults with inflammatory bowel disease
Publication Year: 2025 Source: Health Care Transit PMID: 40236624 DOI: 10.1016/j.hctj.2025.100100
Young adults (approximately 18-35 years) with inflammatory bowel disease (IBD) represent a distinct demographic with unique developmental and physiological characteristics, yet they are underrepresented in clinical trials. This commentary synthesizes insights from a roundtable discussion facilitated by the Crohn's and Colitis Young Adults Network (CCYAN) between young adult patients with …
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