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[Prevention of venous thromboembolic complications in patients with ulcerative colitis]
Publication Year: 2025 Source: Ter Arkh PMID: 40237748
BACKGROUND: The incidence of venous thromboembolic complications (VTEC) in patients with inflammatory bowel diseases is approximately 3 times higher than in the general population and leads to a 2-fold increase in the risk of mortality. The risk of VTEC is the highest during the patient's hospital stay. AIM: To compare …
[Results of non-medical switching from original infliximab to its Russian biosimilar in patients with ulcerative colitis]
Publication Year: 2025 Source: Ter Arkh PMID: 40237750
AIM: To evaluate the efficacy and safety of the Russian biosimilar infliximab in patients with ulcerative colitis (UC). MATERIALS AND METHODS: This is a retrospective study of stable patients with UC, who are followed up at the department of bowel pathology of Loginov Moscow Clinical Scientific Center and who underwent …
[Ultrasound of muscles for the diagnosis of sarcopenia in patients with inflammatory bowel diseases]
Publication Year: 2025 Source: Ter Arkh PMID: 40237752 DOI: 10.26442/00403660.2025.02.203204
AIM: To assess the muscle mass of patients with inflammatory bowel disease (IBD) using ultrasound. MATERIALS AND METHODS: 102 IBD patients hospitalized in gastroenterology department of Republican Clinical Hospital (Kazan) were involved in the study. Among them, 49% of patients with ulcerative colitis, 51% with Crohn's disease, 10 people made …
[Russian Cross-disciplinary Consensus on the diagnosis and treatment of spondyloarthritis associated with inflammatory bowel diseases]
Publication Year: 2025 Source: Ter Arkh PMID: 40237758 DOI: 10.26442/00403660.2025.02.203117
The Russian Cross-disciplinary Consensus on the diagnositic and treatment of spondyloarthritis (SpA) in inflammatory bowel diseases (IBD) was prepared on the initiative of the Loginov Moscow Clinical Scientific Center, using the Delphic system. Its purpose was to consolidate the opinions of experts on the most actual issues of diagnosis and …
Pioglitazone mitigates acetic acid-induced colitis in rats via epigenetic-modulation and antioxidant mechanisms
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40237797
Ulcerative colitis (UC) is one of the inflammatory bowel diseases characterized by colonic damage. Epigenetic mechanisms are suggested to play a role in the pathogenesis of UC. Pioglitazone has shown promise for the treatment of UC; however, the role of epigenetic pathways in this effect is unclear. The current study …
Obesity Is Associated with Inferior Clinical Treatment Outcomes in Inflammatory Bowel Disease: A Nationwide Dutch Registry Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40237911 DOI: 10.1007/s10620-025-09052-5
PURPOSE: To examine the impact of obesity on treatment outcomes in inflammatory bowel disease (IBD). METHODS: Patients aged >/= 16 years, with IBD, a documented baseline body mass index (BMI), and starting thiopurines and allopurinol, intravenous (iv) vedolizumab, subcutaneous (sc) vedolizumab, ustekinumab, ozanimod, filgotinib, or tofacitinib were selected from the …
Use and Cost of First-Line Biologic Medications to Treat Plaque Psoriasis in the US
Publication Year: 2025 Source: JAMA Dermatol PMID: 40238112
IMPORTANCE: Plaque psoriasis is increasingly managed using anti-inflammatory biologic medications, including tumor necrosis factor (TNF)-alpha and interleukin (IL) 12/23, IL-17, and IL-23 inhibitors. How these differently priced biologics are used has implications for the overall cost of care in the US. OBJECTIVE: To measure trends in the use and cost …
A Spermidine Derivative Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Inhibiting the MAPK4/AKT Signaling Pathway
Publication Year: 2025 Source: Foods PMID: 40238233
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent episodes and an inability to achieve a complete cure. The spermidine derivative (di-p-coumaroyl-caffeoyl spermidine, SPDD), as a key alkaloid, exhibits unique health benefits. However, it has not yet been reported whether SPDD can improve dextran sulfate sodium (DSS)-induced …
Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder
Publication Year: 2025 Source: Foods PMID: 40238337
Addressing the escalating global burdens of inflammatory bowel disease and antimicrobial resistance demanded innovative food-based approaches to fortify gut health and suppress pathogens. We introduced a novel edible probiotic, Enterococcus faecalis HY0110, isolated from marine Thunnus thynnus. Through comprehensive in vitro, in vivo, and metabolomic analyses, we demonstrated its superior …
Hydroxytyrosol Ameliorates Colon Inflammation: Mechanistic Insights into Anti-Inflammatory Effects, Inhibition of the TLR4/NF-κB Signaling Pathway, Gut Microbiota Modulation, and Liver Protection
Publication Year: 2025 Source: Foods PMID: 40238502 DOI: 10.3390/foods14071270
Inflammatory bowel disease (IBD) is a chronic disease influenced by a complex interplay of factors, including genetics, environmental, and gut microbiota. This study aimed to explore the therapeutic potential of the natural polyphenolic compound hydroxytyrosol (HT) in modulating dextran sodium sulfate (DSS)-induced colitis in mice. The findings demonstrate that oral …
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