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Zero inflated high dimensional compositional data with DeepInsight
Publication Year: 2025 Source: PLoS One PMID: 40238826 DOI: 10.1371/journal.pone.0320832
Through the Human Microbiome Project, research on human-associated microbiomes has been conducted in various fields. New sequencing techniques such as Next Generation Sequencing (NGS) and High-Throughput Sequencing (HTS) have enabled the inclusion of a wide range of features of the microbiome. These advancements have also contributed to the development of …
Recurrent Thrombosis and Major Bleeding in Children Treated for VTE
Publication Year: 2025 Source: Blood Adv PMID: 40239053
Risk factors for recurrent venous thromboembolism (VTE) in children are poorly understood, and concerns about risks of anticoagulant therapy in children remain. This single-center, cohort with nested case-control study aimed to determine the incidence rate of recurrent thrombosis and associated risk factors and the incidence of major bleeding in children …
Genotype-specific immune responses at the intestinal barrier predispose to colitis in mouse models of chronic granulomatous disease
Publication Year: 2025 Source: Blood PMID: 40239128 DOI: 10.1182/blood.2024026332
Chronic granulomatous disease (CGD) is an inborn error of immunity that is caused by defects in any 1 of the 5 subunits (gp91phox, p47phox, p22phox, p67phox, p40phox) that form the NAD phosphate oxidase complex 2 (NOX2) or in the chaperone protein essential for reactive oxygen species (ROS) that supports its …
The importance of MUC6 immunohistochemistry staining in the histopathologic examination of Crohn's disease: can we enhance our diagnostic power?
Publication Year: 2025 Source: Ann Diagn Pathol PMID: 40239438
Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by transmural inflammation and histopathologic variability, making diagnosis challenging. Pseudopyloric metaplasia (PPM) is a key histological feature of chronicity in CD. However, its identification on hematoxylin & eosin (H&E)-stained slides is subject to interobserver variability. MUC6 immunohistochemistry (IHC) has been …
Discovery of a deuterated TNF-α small molecule modulator for potential treatment of ulcerative colitis
Publication Year: 2025 Source: Eur J Med Chem PMID: 40239485
Tumor necrosis factor-alpha (TNF-alpha) is an important target for the treatment of inflammatory diseases. Targeting TNF-alpha inhibition, such as antibody drug infliximab and adalimumab, has emerged as an effective therapeutic strategy for managing the most difficult-to-treat chronic ulcerative colitis (UC). So far, there are no small molecule TNF-alpha inhibitors available …
Association between long-term benzene exposure and inflammatory bowel disease in a national cohort: The modifying effect of genetic susceptibility
Publication Year: 2025 Source: Ecotoxicol Environ Saf PMID: 40239550 DOI: 10.1016/j.ecoenv.2025.118198
BACKGROUND: This study aimed to investigate the effects of environmental benzene exposure and its interaction with genetic susceptibility on inflammatory bowel disease (IBD), with a specific focus on ulcerative colitis (UC) and Crohn's disease (CD). METHODS: A total of 432,727 participants from the UK Biobank who were free of IBD …
Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity
Publication Year: 2025 Source: Cell PMID: 40239649
Microbiota-derived bile acids (BAs) are associated with host biology/disease, yet their causal effects remain largely undefined. Herein, we speculate that characterizing previously undefined microbiota-derived BAs would uncover previously unknown BA-sensing receptors and their biological functions. We integrated BA metabolomics and microbial genetics to functionally profile >200 putative microbiota BA metabolic …
Postoperative Outcomes in Tofacitinib-Treated Patients With Acute Severe Ulcerative Colitis Undergoing Colectomy
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40239733
BACKGROUND AND AIMS: Up to 30% of patients with acute severe ulcerative colitis (ASUC) will require urgent colectomy despite initiation of intravenous corticosteroids and rescue therapies. Janus kinase inhibitors, such as tofacitinib, have emerged as an effective agent for ASUC; however, there are currently limited data evaluating the risk of …
Cellular and molecular mechanisms in the pathogenesis of pouchitis: more than just the microbiota
Publication Year: 2025 Source: Gut PMID: 40240062
Pouchitis, defined as inflammation of the ileal pouch, is the most common complication following restorative proctocolectomy for refractory ulcerative colitis. Antibiotics remain the first line of therapy for pouchitis, but the majority of patients develop subsequent episodes and some are refractory to antibiotic therapy. This highlights the need for more …
Incidence of Myocarditis Caused by Drugs Used for Ulcerative Colitis as Examined Using VigiBase, a Spontaneous Adverse Drug Reaction Reporting Database
Publication Year: 2025 Source: Biol Pharm Bull PMID: 40240171
Although myocarditis is listed as a serious adverse reaction in the package inserts of mesalazine and some other anti-ulcerative colitis (UC) drugs currently in use, and regulatory authorities have issued related warnings, the detailed characteristics of anti-UC drug-induced myocarditis remain unknown. We aimed to investigate the association between UC drugs …
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