Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Comment on "Prevalence and outcomes of arthritis in pediatric IBD: A study from the Italian society of pediatric gastroenterology hepatology and nutrition"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40240195 DOI: 10.1016/j.dld.2025.03.015
No Abstract
Usefulness of thiopurines therapeutic drug monitoring in patients with inflammatory bowel disease
Publication Year: 2025 Source: Therapie PMID: 40240270 DOI: 10.1016/j.therap.2025.03.001
INTRODUCTION: Thiopurine drugs, the most commonly prescribed immunosuppressive agents used in the treatment of inflammatory bowel disease (IBD), are characterized by a narrow therapeutic window, which makes therapeutic drug monitoring (TDM) of thiopurine metabolites recommended. 6-thioguanine nucleotides (6-TGN) are considered the most active metabolites of the thiopurines and they are …
Breastfeeding and Health Outcomes for Infants and Children: A Systematic Review
Publication Year: 2025 Source: Pediatrics PMID: 40240318
CONTEXT: Our understanding of the benefits of breastfeeding and the consumption of human milk for specific infant outcomes and the magnitude of those benefits continues to evolve. OBJECTIVE: Review the evidence on the association between breastfeeding and child health outcomes. DATA SOURCES: Systematic literature searches in MEDLINE, Embase, and CINAHL …
Cytomegalovirus infection initiates inflammatory bowel disease by activating a positive MyD88/NF-κB feedback loop in allogeneic skin transplantation mice
Publication Year: 2025 Source: Virol J PMID: 40241182 DOI: 10.1186/s12985-025-02725-7
Infection with the cytomegalovirus (CMV) is common. Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract. CMV infection is involved in IBD pathogenesis. The abnormal activation of myeloid differentiation factor 88 (MyD88)/nuclear factor- kappa B (NF-kappaB) signaling, which results in inflammatory cytokine overexpression, is an important …
Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis
Publication Year: 2025 Source: Turk J Gastroenterol PMID: 40241612
BACKGROUND/AIMS: Ulcerative colitis (UC), an idiopathic and chronic inflammatory disease, primarily targets the mucosal lining of the colon. This research endeavors to reveal the mechanism of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and nuclear receptor coactivator-3 (NCOA3) in UC-induced intestinal mucosal barrier dysfunction. MATERIALS AND METHODS: Dextran sodium …
A real-world, observational, prospective cohort study evaluating the safety and effectiveness of CT-P13 in inflammatory bowel disease and rheumatoid arthritis: the MEGA-J study
Publication Year: 2025 Source: Curr Med Res Opin PMID: 40241664
OBJECTIVE: The primary objective of the MEGA-J study (UMIN-CTR number: UMIN000057308) was to assess the safety of CT-P13, an infliximab biosimilar, in Japanese patients with Crohn's disease (CD), ulcerative colitis (UC), and/or rheumatoid arthritis (RA) after switching from reference infliximab. METHODS: Data were collected over 5 years, following initiation of …
Colon-Targeted β(3)-Adrenoceptor Agonist Mirabegron Enhances Anticolitic Potency of the Drug via Potentiating the Nrf2-HO-1 Pathway
Publication Year: 2025 Source: Mol Pharm PMID: 40241685
The selective agonist of beta(3)-adrenergic receptor mirabegron (MBG), clinically used to treat overactive bladders, exerts beneficial effects in animal models of colitis. Here, we aimed to enhance the therapeutic activity and safety of MBG as an anticolitic drug by implementing colon-targeted drug delivery using a prodrug approach. MBG was azo-linked …
Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40242025
BACKGROUND: Clinically, Qing-Re-Hua-Shi Decoction (QRHSD) has been clinically used to treat ulcerative colitis (UC) with satisfactory outcomes and minimal side effects. However, its molecular mechanisms remain unclear. PURPOSE: This study investigates the effects of QRHSD on DSS-induced colitis in mice, employing multi-omics analyses, including RNA-seq transcriptomics, 16S rRNA microbiomics, non-targeted …
Long non-coding RNA ANRIL/p65 negative feedback loop protects intestinal barrier function in inflammatory bowel disease
Publication Year: 2025 Source: Noncoding RNA Res PMID: 40242051 DOI: 10.1016/j.ncrna.2025.03.002
Patients with inflammatory bowel disease (IBD) demonstrate varying expression levels of long non-coding RNAs (lncRNAs) in their intestinal mucosa, which can potentially impact the function of the intestinal barrier. This impact may occur through the modulation of epithelial cell apoptosis, alteration of intestinal mucosal barrier permeability, and enhancement of inflammatory …
Pharmacological modulation of mitochondrial function as novel strategies for treating intestinal inflammatory diseases and colorectal cancer
Publication Year: 2025 Source: J Pharm Anal PMID: 40242218 DOI: 10.1016/j.jpha.2024.101074
Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal disease, and has become a major global health issue. Individuals with IBD face an elevated risk of developing colorectal cancer (CRC), and recent studies have indicated that mitochondrial dysfunction plays a pivotal role in the pathogenesis of both IBD and …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide