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Changes in T Lymphocytes and Cytokines After Anti-TNF Treatment in Pediatric Inflammatory Bowel Disease: Association with Response to Pharmacologic Therapy
Publication Year: 2025 Source: Int J Mol Sci PMID: 40244207 DOI: 10.3390/ijms26073323
Failure of anti-TNF therapy is a real concern in children with inflammatory bowel disease (IBD) owing to the limited therapeutic arsenal. Anti-TNF drugs modulate the immune response, a key driver of chronic inflammation in IBD. Accordingly, we analyzed changes in the frequency of T-lymphocyte and cytokine levels after 6 weeks …
PTPN2 Regulates Iron Handling Protein Expression in Inflammatory Bowel Disease Patients and Prevents Iron Deficiency in Mice
Publication Year: 2025 Source: Int J Mol Sci PMID: 40244226 DOI: 10.3390/ijms26073356
Anemia is the most common extraintestinal manifestation of inflammatory bowel disease (IBD). Iron deficiency is the most frequent cause of anemia in IBD; however, the mechanisms involved are still poorly understood. Here, we investigated the role of the IBD risk gene, protein tyrosine phosphatase non-receptor type 2 (PTPN2), in regulating …
Fecal miRNA Profiling of Yorkshire Terrier Enteropathy
Publication Year: 2025 Source: Int J Mol Sci PMID: 40244288 DOI: 10.3390/ijms26073385
MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation and are potential biomarkers for several diseases, including canine enteropathies. While metabolite profiling and microbiome in canine enteropathies have been previously explored, data on miRNA expression remain limited. This study aimed to profile miRNA expression in Yorkshire Terrier canine enteropathy …
Evaluation of an Exercise Program in Patients with Inflammatory Bowel Disease: A Pilot Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40244344 DOI: 10.1007/s10620-025-09030-x
PURPOSE: Patients with inflammatory bowel disease (IBD) tend to be less physical active, while maintaining an active lifestyle has been associated with enhanced disease control, diminished fatigue, and improved quality of life. This study aimed to evaluate the feasibility and potential impact of an exercise program for patients with IBD. …
Exploring the Mucosal Immune Response in Axial Spondyloarthritis Through Immunoglobulin A-Coated Microbiota
Publication Year: 2025 Source: Rheum Dis Clin North Am PMID: 40246441
In this review, we focus on the mucosal immune response through Immunoglobulin A (IgA)-coated microbes and their role in gut dysbiosis in axial spondyloarthritis (axSpA) and associated inflammatory bowel disease. IgA-coated microbes contribute significantly to the microbial dysbiosis observed in axSpA, potentially driving gut inflammation and translocating outside of the …
Fecal microbiota transplantation for patients with ulcerative colitis: a systematic review and meta-analysis of randomized control trials
Publication Year: 2025 Source: Tech Coloproctol PMID: 40246750
BACKGROUND: Fecal microbiota transplantation (FMT) has been shown to restore gut microbiome composition with an acceptable safety profile. FMT in inflammatory bowel disease, specifically ulcerative colitis (UC), has been investigated. We aimed to assess the efficacy of FMT in inducing UC remission. METHODS: PubMed, Scopus, Google Scholar, and clinicaltrials.gov were …
Disease-specific B cell clones are shared between patients with Crohn's disease
Publication Year: 2025 Source: Nat Commun PMID: 40246842
B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn's disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B …
Relationship between smoking status and ulcerative colitis: a meta-analysis based on a case-control study
Publication Year: 2025 Source: Sci Rep PMID: 40246988
Prior research has revealed an association between smoking, reduced ulcerative colitis (UC) risk, and improved disease severity among individuals with existing UC. Herein, we analysed the interaction between smoking habits and UC and its potential complexity, focusing on associations between smoking, incidence of UC, and therapeutic outcomes, via a meta-analysis …
Efficacy and safety of Mirikizumab for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40301737
Ulcerative colitis (UC) is a widespread incurable chronic inflammation of the colon mucosa. Currently, oral small-molecule medications targeting Janus kinase or sphingosine-1-phosphate and monoclonal antibodies to TNF-alpha,alpha4beta7 integrins and Ustekinumab are the lines of treatment for UC. Up to 50% of patients either do not react to initial treatment or …
Prevalence of H. Pylori in inflammatory bowel disease patients and its association with severity
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40301738 DOI: 10.1186/s12876-025-03892-1
INTRODUCTION: One key area of interest in gastroenterology research is the relationship between Helicobacter pylori (H. pylori) and Inflammatory bowel disease (IBD). Several studies have shown varying results regarding the prevalence of H. pylori in IBD patients and its impact on disease progression, severity, and overall outcome. METHOD: This is …
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