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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation
Publication Year: 2025 Source: Mol Med PMID: 40301757 DOI: 10.1186/s10020-025-01230-5
BACKGROUND: Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive. Tumor necrosis factor alpha stimulated gene 6 (TSG-6) is a secretory protein with anti-inflammatory properties. Our previous research demonstrated TSG-6 can relieve intestinal inflammation and mucosal damage. However, the underlying mechanism and …
A single-centre analysis of a biosimilar switching programme for adalimumab in inflammatory bowel disease
Publication Year: 2025 Source: Br J Clin Pharmacol PMID: 40302144 DOI: 10.1002/bcp.70086
AIMS: Amgevita is a licensed biosimilar to adalimumab, having demonstrated high pharmacokinetic and clinical similarity to Humira. Switching to a lower-cost medicine may elicit a nocebo effect, whereby expectations of poorer efficacy impact outcomes despite pharmacological similarity. This prospective cohort study examined clinical and economic outcomes and associated psychosocial variables …
Editorial: Inflammatory Bowel Disease and Dietary Emulsifiers-A Conundrum That Continues
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40302181
No Abstract
Editorial: Inflammatory Bowel Disease and Dietary Emulsifiers-A Conundrum That Continues. Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40302195
No Abstract
The effects of biologics on ulcerative colitis-related colectomy rate: results of a 22-year study
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40302309
BACKGROUND: To assess the impact of the biological era on colectomy rates in ulcerative colitis (UC) patients and identify factors associated with the necessity for colectomy in a large cohort from Eastern Europe. METHODS: A retrospective cohort study was conducted on UC patients followed at a tertiary care center covering …
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis
Publication Year: 2025 Source: ACS Nano PMID: 40302522
Ulcerative colitis (UC) is a chronic inflammatory condition that imposes a huge healthcare burden globally. The inflamed colon is marked by an abundance of positively charged proteins, increased reactive oxygen species (ROS), a disrupted intestinal barrier, and an imbalanced gut microbiome. Leveraging these features, we designed a negatively charged ROS-responsive …
Ano-Bartholin's Gland Fistula Caused by Anal Fistula in a Patient without Crohn's Disease: A Case Report
Publication Year: 2025 Source: J Anus Rectum Colon PMID: 40302865
We report a rare case of an ano-Bartholin's gland fistula caused by an anal fistula in a patient without Crohn's disease (CD). A 34-year-old woman was admitted to our hospital due to purulent anal discharge and left vulvar pain. She had experienced several Bartholinitis in the past 2 years. She …
Advanced Therapies in Elderly Patients With Inflammatory Bowel Disease: A Comparative Retrospective Cohort Study in Taiwan
Publication Year: 2025 Source: Ther Clin Risk Manag PMID: 40303313 DOI: 10.2147/TCRM.S518405
PURPOSE: Inflammatory Bowel Disease (IBD) predominantly affects younger individuals, but emerging data indicates a shift toward older populations. Elderly-onset IBD (diagnosed at 60 years or older) differs from younger-onset IBD, presenting with atypical symptoms and higher risks of infections and malignancies. However, drug persistence is underexplored in the elderly IBD …
Phylogenetic analysis of vp2 gene of the infectious bursal disease virus in South China during 2023
Publication Year: 2025 Source: Front Vet Sci PMID: 40303390 DOI: 10.3389/fvets.2025.1575407
Infectious Bursal Disease (IBD) is an acute, highly infectious, immunosuppressive disease caused by the infectious bursal disease virus (IBDV). To elucidate the prevalence of IBDV in southern China, a total of 60 tissues (including spleen and bursa) suspected of IBDV infection were collected from broiler chickens in 2023. In this …
Supersulfide controls intestinal inflammation by suppressing CD4(+) T cell proliferation
Publication Year: 2025 Source: Front Immunol PMID: 40303402 DOI: 10.3389/fimmu.2025.1506580
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation where CD4(+) T lymphocytes play an essential role. Accumulating evidence suggests that immune responses driven by CD4(+) T cells are critically regulated by various metabolic pathways including oxidative phosphorylation and glycolysis. Here we show that CARS2/CPERS-dependent supersulfide metabolism restrains CD4(+) …
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