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MH002, a Novel Butyrate-Producing Consortium of Six Commensal Bacterial Strains Has Immune-Modulatory and Mucosal-Healing Properties
Publication Year: 2025 Source: Int J Mol Sci PMID: 40649947
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the gastrointestinal tract. It is generally accepted that IBD is characterized by an inappropriate immune response to the intestinal microbiome in genetically susceptible individuals. Despite the available treatment options ranging from salicylates and corticosteroids, to immunosuppressants and biologics, there …
Causal Inference and Shared Molecular Pathways in Crohn's Disease, Celiac Disease, and Ankylosing Spondylitis: Integrative Mendelian Randomization and Transcriptomic Analysis
Publication Year: 2025 Source: Int J Mol Sci PMID: 40650227
This study explored the causal and molecular overlap among Crohn's disease (CD), celiac disease (CeD), and ankylosing spondylitis (AS). Bidirectional Mendelian randomization revealed significant causal associations between each disease pair. Transcriptomic analyses identified three consistently upregulated hub genes-P2RY8, ITGAL, and GPR65-across all conditions, which were validated in independent datasets and …
Nanomedicine Strategies in the Management of Inflammatory Bowel Disease and Colorectal Cancer
Publication Year: 2025 Source: Int J Mol Sci PMID: 40650240
The gut microbiota has emerged as a key area of biomedical research due to its integral role in maintaining host health and its involvement in the pathogenesis of many systemic diseases. Growing evidence supports the notion that gut dysbiosis contributes significantly to diseases and their progression. An example would be …
Psychopharmacological Therapy Positively Modulates Disease Activity in Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: Int J Mol Sci PMID: 40650291
Depression, anxiety, and perceived stress are common comorbidities in patients with inflammatory bowel disease (IBD) and may negatively influence the disease course. Likewise, severe IBD may contribute to the development or worsening of psychiatric symptoms. Despite the established relevance of the gut-brain axis and frequent use of psychotropic medications in …
Associations of Long-Term Night Shift Work With Incident Irritable Bowel Syndrome: A Population-Based Cohort Study
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40650456
BACKGROUND AND AIM: To explore the impact of long-term night shift work on the incidence of irritable bowel syndrome (IBS) and the underlying mechanism. METHODS: This cohort study included 239 760 participants who were in paid employment or self-employed from the UK Biobank. The start date refers to the date …
Endoscopic Recurrence in Crohn's Disease Patients With Long-Term Ileostomy
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40650505
BACKGROUND: A small but significant proportion of patients with Crohn's disease (CD) will ultimately require a permanent ileostomy. So far, research has focused primarily on clinical and surgical recurrence rates in the ileum, leaving endoscopic recurrence largely unexplored. The aim of this study was to explore the endoscopic ileal recurrence …
The Association of Inflammatory Bowel Disease and Eosinophilic Esophagitis: True Link or Surveillance Artifact?
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40650507
No Abstract
Carbon-Coated Probiotics Restore Intestinal Homeostasis to Promote Damage Repair in Inflammatory Bowel Disease
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40650583
Inflammatory bowel disease (IBD) is regarded as green cancer that seriously endangers human quality of life. Orally administered probiotic treatment has been regarded as a promising strategy for the adjunctive treatment of IBD. However, its efficacy is greatly inhibited due to the harsh gut microenvironment and low targeted delivery volume. …
Eggerthella lenta Produces a Cryptic Pro-inflammatory Lipid
Publication Year: 2025 Source: J Am Chem Soc PMID: 40650585
Eggerthella lenta is both one of the most studied and least understood members of the human gut microbiome. Most of the interest in this Gram-positive anaerobe originates from multiple robust associations of its population with a variety of autoimmune diseases, perhaps most notably inflammatory bowel disease (IBD). The links between …
ACSS2-Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40650658
Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (IBD) remain poorly explored. Herein, a notable decrease of both Pan-Kcr and ACSS2 (acyl-CoA synthetase short-chain family member 2), the key …
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