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Carrier-Free Nanocapsule with Dual-Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40650704
Inflammatory bowel disease (IBD) is a chronic inflammatory disease with limited therapeutic outcomes. Macrophages are the key gatekeepers of intestinal immune homeostasis and have vital influence on IBD. Hence, macrophages are recognized as attractive targets to develop new therapeutic. However, the therapy development has proven challenging due to the malignant …
Nervous Breakdown: Chronic Inflammatory Demyelinating Polyneuropathy as an Extra-Intestinal Manifestation of Ulcerative Colitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 40650855
No Abstract
Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa
Publication Year: 2025 Source: Br J Dermatol PMID: 40650879
BACKGROUND: Hidradenitis suppurativa (HS) is a common, chronic, and debilitating inflammatory disease that most commonly affects intertriginous skin. Despite its high heritability, the genetic underpinnings of HS remain poorly understood. OBJECTIVE: To identify genetic signals associated with HS, determine genetic relationships with other diseases, and investigate potential molecular genetic mechanisms. …
Fecal and Serum Metabolome in Crohn's Disease is Linked With Future Flare
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40650893
BACKGROUND: Metabolites are key mediators of various physiological functions. However, there is a lack of data linking their levels to future Crohn's Disease (CD) flares. OBJECTIVE: We aimed to identify systemic and gut metabolic changes that precede flare and generate metabolite-based indexes that predict flare using a test cohort, with …
ECCO Consensus on Dietary Management of Inflammatory Bowel Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40650933
No Abstract
ECCO consensus on management of Inflammatory Bowel Disease in low-and middle-income countries
Publication Year: 2025 Source: J Crohns Colitis PMID: 40651004
BACKGROUND: The incidence and prevalence of inflammatory bowel disease [IBD] have increased significantly in low- and middle-income countries [LMICs] in recent decades. Managing IBD in these settings presents substantial challenges. This consensus aims to describe the epidemiology of IBD in LMICs and to highlight the key challenges in its diagnosis …
Scoring indices for assessing endoscopic disease activity in acute severe ulcerative colitis: A systematic review
Publication Year: 2025 Source: J Crohns Colitis PMID: 40651008
BACKGROUND AND AIMS: Endoscopy is important for assessing disease severity and potentially predicting treatment response in acute severe ulcerative colitis (ASUC). We aimed to identify and determine the operating properties of existing endoscopic indices/items used to assess disease activity in ASUC. METHODS: MEDLINE, Embase, and Cochrane CENTRAL were searched from …
Microfluidic Fabrication of Hyaluronic Acid-Cysteine-Modified Chitosan Microspheres for CD44-Targeted Probiotic Delivery in Colitis Treatment
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40651026
Probiotics play a crucial role in regulating intestinal immune homeostasis and supporting gut health; however, oral administration faces challenges such as nonspecific distribution and low efficacy. To achieve precise and efficient delivery, in this study, a targeted delivery system embedded probiotics to the colonic inflammatory site CD44 was constructed by …
The role of resilience in mitigating depression and anxiety in patients with inflammatory bowel diseases
Publication Year: 2025 Source: J Psychosom Res PMID: 40651325
BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), often triggers psychological distress. Resilience, the ability to adapt to stress and trauma, may mitigate the psychological effects of chronic illnesses. AIMS: To determine whether higher psychological resilience is independently associated with reduced anxiety and depressive symptoms …
Data-Independent Acquisition Analysis to Identify Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases
Publication Year: 2025 Source: J Proteome Res PMID: 40652393
Early colorectal cancer (CRC) detection among inflammatory bowel disease improves treatment outcomes and survival. A sensitive and specific serum-based tool can bridge the gap between patient presentation and invasive colonoscopy, thereby enhancing early diagnosis. We screened serum biomarkers in colonoscopy-positive (CP, cancer) and colonoscopy-negative (CN, other bowel diseases) individuals, as …
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