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Rates, Predictors, and Outcomes of Ustekinumab Dose Escalation in Inflammatory Bowel Disease

Publication Year: 2025 Source: J Clin Gastroenterol PMID: 38595134 DOI: 10.1097/MCG.0000000000002003

OBJECTIVE: Ustekinumab (UST) is effective for the induction and maintenance of remission in inflammatory bowel disease (IBD). However, a significant proportion of patients will require UST dose escalation. We sought to determine the rates, predictors, and outcomes of UST dose escalation in patients with IBD. PATIENTS AND METHODS: This was …

Clinical effectiveness and safety of ustekinumab in youth with refractory inflammatory bowel disease: A retrospective cohort study

Publication Year: 2025 Source: Saudi J Gastroenterol PMID: 38597337 DOI: 10.4103/sjg.sjg_7_24

BACKGROUND: Inflammatory bowel disease (IBD) incidence and prevalence has been increasing worldwide. Limited data exists on the effectiveness of ustekinumab (UST) in children. We aimed to describe the effectiveness and safety of UST in pediatric patients with IBD. METHODS: A single-center retrospective study was conducted between January 2017 and February …

Changes Over Time in the Lémann Index and the Inflammatory Bowel Disease Disability Index in a Prospective Cohort of Patients With Crohn's Disease

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38597799 DOI: 10.1093/ibd/izae073

BACKGROUND: Crohn's disease (CD) is a progressive, destructive, and disabling disorder. Our study aimed to assess changes over time in the Lemann index (LI) and the Inflammatory Bowel Disease Disability Index (IBD-DI) in a cohort of CD patients. METHODS: This was a single-center prospective cohort study of 130 consecutive CD …

Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms

Publication Year: 2025 Source: Crit Rev Microbiol PMID: 38602474

No Abstract

Long-term mental and physical quality of life outcomes following ileal pouch anal anastomosis surgery

Publication Year: 2025 Source: Ann R Coll Surg Engl PMID: 38362797 DOI: 10.1308/rcsann.2023.0075

INTRODUCTION: This study presents the authors' experience over 14 years of performing restorative procto-colectomy with ileal pouch anal anastomosis (IPAA). The aim was to study the long-term quality of life outcomes and analyse the predictors of pouch function as well as physical and mental wellbeing. METHODS: This is a single-centre …

Ultra-processed food consumption and human health: an umbrella review of systematic reviews with meta-analyses

Publication Year: 2025 Source: Crit Rev Food Sci Nutr PMID: 38363072

No Abstract

Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study

Publication Year: 2025 Source: Intest Res PMID: 38373704 DOI: 10.5217/ir.2023.00078

BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) is a common disease with severe inflammatory processes associated with numerous gastrointestinal diseases, such as inflammatory bowel disease (IBD). Therefore, we investigated the relationship between NAFLD and IBD and the possible risk factors associated with the diagnosis of IBD. METHODS: This longitudinal nationwide cohort …

Risk of tuberculosis with anti-TNF therapy in Indian patients with inflammatory bowel disease despite negative screening

Publication Year: 2025 Source: Arab J Gastroenterol PMID: 38383265 DOI: 10.1016/j.ajg.2024.01.013

BACKGROUND AND STUDY AIMS: Tuberculosis (TB) is a well-recognized adverse effect associated with using biological therapy to manage various autoimmune conditions. There is a dearth of information about the development of TB after using anti-TNF agents in patients with inflammatory bowel disease (IBD) from TB-endemic countries like India. This study …

Impact on patient outcomes of spondyloarthritis-inflammatory bowel disease multi-disciplinary meetings

Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 38391112 DOI: 10.1093/rheumatology/keae116

OBJECTIVES: To assess the impact on patient outcomes of the spondyloarthritis (SpA) and inflammatory bowel disease (IBD) multidisciplinary team (MDT) meetings in a large university hospital. METHODS: A single-centre retrospective observational case-note review was conducted assessing the outcome of all 226 cases discussed at the SpA-IBD MDT meetings in a …

The role of IL-19, IL-24, IL-21 and IL-33 in intestinal mucosa of inflammatory bowel disease: A narrative review

Publication Year: 2025 Source: Arab J Gastroenterol PMID: 38395629 DOI: 10.1016/j.ajg.2024.01.002

Interleukins are potential therapeutic targets that can alter the prognosis and progression of inflammatory bowel disease (IBD). The roles of IL-6, IL-10, IL-17, and IL-23 have been extensively studied, setting the stage for the development of novel treatments for patients with IBD. Other cytokines have been less extensively studied. Members …

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