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Real-World Effectiveness of Ustekinumab in Ulcerative Colitis in a United States Multicenter Cohort Consortium
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38531068
BACKGROUND: Pivotal trials have shown that ustekinumab is effective in ulcerative colitis (UC). However, the population included in these trials do not represent the cohort of patients treated in the real world. In this study, we aimed to describe the effectiveness and safety of ustekinumab in a clinical cohort of …
Accurate, Robust, and Scalable Machine Abstraction of Mayo Endoscopic Subscores From Colonoscopy Reports
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38533919
BACKGROUND: The Mayo endoscopic subscore (MES) is an important quantitative measure of disease activity in ulcerative colitis. Colonoscopy reports in routine clinical care usually characterize ulcerative colitis disease activity using free text description, limiting their utility for clinical research and quality improvement. We sought to develop algorithms to classify colonoscopy …
Prospective Evaluation of Serum Free Thiols in Inflammatory Bowel Disease: A Candidate to Replace C-Reactive Protein for Disease Activity Assessment?
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38537201 DOI: 10.1093/ibd/izae069
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. …
Crohn's Disease Phenotypes and Associations With Comorbidities, Surgery Risk, Medications and Nonmedication Approaches: The MAGIC in IMAGINE Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38537257 DOI: 10.1093/ibd/izae055
BACKGROUND: We aimed to establish a cohort of persons with Crohn's disease (CD) enrolled from 14 Canadian centers to describe the contemporary presentation of CD in Canada. METHODS: All enrollees were at least 18 years old and underwent chart review for phenotype documentation by Montreal Classification at time of enrollment, …
Objective and Subjective Dysphagia Assessment in Inflammatory Bowel Diseases
Publication Year: 2025 Source: Folia Phoniatr Logop PMID: 38537618 DOI: 10.1159/000538514
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease that is separated into two types: ulcerative colitis (UC) and Crohn's disease (CD). Although dysphagia is a well-studied and important topic in head and neck cancers and neurological disorders, research on the relationship between IBD and swallowing problems is not …
Phosphomannomutase 2-congenital disorder of glycosylation presenting with very early onset inflammatory bowel disease
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 38539012
No Abstract
Rediversion of the Failing Ileoanal Pouch: First Step in Pouch Salvage?
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38546722
BACKGROUND: Ileal pouch-anal anastomosis is a technically demanding procedure with many potential complications. Rediversion with an ileostomy is often the first step in pouch salvage; however, it may not be clear if an individual patient will undergo subsequent pouch salvage surgery. We aimed to describe the indications and short- and …
Operating Properties of Disease Activity Indices in Pediatric Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38547511
BACKGROUND: Accurate, reliable, and responsive disease activity indices are important to streamline drug approval and treatment modalities for pediatric inflammatory bowel disease (pIBD). We aimed to identify all scoring indices used in pIBD randomized controlled trials (RCTs) and to evaluate their operating properties. METHODS: MEDLINE, EMBASE, and CENTRAL were searched …
Efficacy of probiotic supplementation and impact on fecal microbiota in patients with inflammatory bowel disease: a systematic review and meta-analysis of randomized controlled trials
Publication Year: 2025 Source: Nutr Rev PMID: 38553410 DOI: 10.1093/nutrit/nuae022
Context: Research regarding the treatment of inflammatory bowel disease (IBD) with probiotics has not yielded consistent results. OBJECTIVE: The aim of this meta-analysis was to evaluate the efficacy of probiotics supplementation in patients with IBD. DATA SOURCES: Randomized controlled trials (RCTs) evaluating the efficacy of probiotics in patients with IBD …
Endoscopic seton placement for inflammatory bowel disease (IBD) and non-IBD, simple or complex fistula: A pilot prospective study (with video)
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 38557943 DOI: 10.1007/s12664-024-01568-4
No Abstract
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