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Systematic identification of secondary bile acid production genes in global microbiome
Publication Year: 2025 Source: mSystems PMID: 39688414 DOI: 10.1128/msystems.00817-24
Microbial metabolism of bile acids (BAs) is crucial for maintaining homeostasis in vertebrate hosts and environments. Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes, metabolic enzymes, and bile acid remains incomplete. To bridge this gap, we employed hidden Markov models …
Multimedia: multimodal mediation analysis of microbiome data
Publication Year: 2025 Source: Microbiol Spectr PMID: 39688588
No Abstract
Effects of vitamin D and common nettle (Urtica dioica) extract administration on Mn-SOD and Catalase (CAT) secretion in the colon tissues of rats with experimentally induced Crohn's disease
Publication Year: 2025 Source: Biotech Histochem PMID: 39688604
No Abstract
Improvement of Transmural Inflammation With Adalimumab Versus Immunomodulator Maintenance Therapy in Pediatric Crohn's Disease: Single-Center Prospective Evaluation Using the Pediatric Inflammatory Crohn's Magnetic Resonance Enterography Index
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39688854
BACKGROUND AND AIMS: Transmural healing, including as assessed by magnetic resonance enterography (MRE) has been associated with long-term favorable outcomes in Crohn's Disease (CD), but data concerning MRE improvement and normalization with therapy are sparse. We performed a prospective longitudinal study utilizing the recently developed pediatric MRE-based multi-item measure of …
Advancing Toward Transmural Healing in Pediatric Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39689021
No Abstract
Comorbidity in incident rheumatoid arthritis: a nationwide case-control study with bidirectional follow-up
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 39689029
OBJECTIVES: To investigate the association between risk of different concurrent disorders and diagnosis of rheumatoid arthritis (RA) using a temporal approach. METHODS: Retrospective, case-control study. Data were extracted from all available healthcare claims for Poland between 2011-2021. Prevalent RA (n = 262 265) patients were examined to evaluate morbidity patterns. …
Health Care and Prescription Medication Affordability for Inflammatory Bowel Disease in the United States in 2023
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39689773
No Abstract
Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress
Publication Year: 2025 Source: Trends Biotechnol PMID: 39689981 DOI: 10.1016/j.tibtech.2024.11.017
Inflammatory bowel disease (IBD) is a chronic relapsing immune-mediated inflammatory disorder of the alimentary tract without exact etiology. Mitochondrial reactive oxygen species (mtROS) derived from mitochondrial dysfunction impair intestinal barrier function, increase gut permeability, and facilitate immune cell invasion, and, therefore, are considered to have a pivotal role in the …
Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice
Publication Year: 2025 Source: Nat Microbiol PMID: 39690194
No Abstract
Human placental stem cell-based therapies for prevention of abdominal adhesions: A prospective randomized preclinical trial
Publication Year: 2025 Source: J Trauma Acute Care Surg PMID: 39690463
No Abstract
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