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Down-regulation of interlinked inflammatory signalling cascades by ethanolic extract of Suaeda fruticosa Forssk. ex J.F. Gmel. attenuated in vivo inflammatory and nociceptive responses
Publication Year: 2025 Source: Inflammopharmacology PMID: 39731702
No Abstract
A postbiotic exopolysaccharide synergizes with Lactobacillus acidophilus to reduce intestinal inflammation in a mouse model of colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39732236
No Abstract
Genome-wide association study of anterior uveitis
Publication Year: 2025 Source: Br J Ophthalmol PMID: 39732499
BACKGROUND/AIMS: The purpose of this study is to define genetic factors associated with anterior uveitis through genome-wide association study (GWAS). METHODS: In this GWAS meta-analysis, we combined data from the FinnGen, Estonian Biobank and UK Biobank with a total of 12 205 anterior uveitis cases and 917 145 controls. We …
Leveraging human microbiomes for disease prediction and treatment
Publication Year: 2025 Source: Trends Pharmacol Sci PMID: 39732609
No Abstract
Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models
Publication Year: 2025 Source: Genet Med PMID: 39733260
No Abstract
Navigating anti-TNF therapy risks: Real-world insights on pregnancy, breastfeeding, and vaccines in IBD patients
Publication Year: 2025 Source: Dig Liver Dis PMID: 39734161 DOI: 10.1016/j.dld.2024.12.007
No Abstract
Prevalence and outcomes of arthritis in pediatric IBD: A multicenter study from the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition
Publication Year: 2025 Source: Dig Liver Dis PMID: 39734162 DOI: 10.1016/j.dld.2024.12.010
BACKGROUND AND AIMS: The aim of the present study was to assess prevalence and disease outcomes of arthritis in a nationwide cohort of pediatric patients with inflammatory bowel disease (IBD). METHODS: We collected data of pediatric IBD patients experiencing arthritis from the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition …
Surface-functionalized bacteria: Frontier explorations in next-generation live biotherapeutics
Publication Year: 2025 Source: Biomaterials PMID: 39736217 DOI: 10.1016/j.biomaterials.2024.123029
Screening robust living bacteria to produce living biotherapeutic products (LBPs) represents a burgeoning research field in biomedical applications. Despite their natural abilities to colonize bio-interfaces and proliferate, harnessing bacteria for such applications is hindered by considerable challenges in unsatisfied functionalities and safety concerns. Leveraging the high degree of customization and …
SLC26A3 (DRA, the Congenital Chloride Diarrhea Gene): A Novel Therapeutic Target for Diarrheal Diseases
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 39736385 DOI: 10.1016/j.jcmgh.2024.101452
Diarrhea associated with enteric infections, gut inflammation, and genetic defects poses a major health burden and results in significant morbidity and mortality. Impaired fluid and electrolyte absorption or secretion in the intestine are the hallmark of diarrhea. Electroneutral NaCl absorption in the mammalian GI tract involves the coupling of Na(+)/H(+) …
Activation of PPARγ regulates M1/M2 macrophage polarization and attenuates dextran sulfate sodium salt-induced inflammatory bowel disease via the STAT-1/STAT-6 pathway
Publication Year: 2025 Source: Kaohsiung J Med Sci PMID: 39737788 DOI: 10.1002/kjm2.12927
This study aimed to investigate whether activation of PPARgamma regulates M1/M2 macrophage polarization to attenuate dextran sulfate sodium salt (DSS)-induced inflammatory bowel disease (IBD) via the STAT-1/STAT-6 pathway in vivo and in vitro. We first examined the effect of PPARgamma on macrophage polarization in LPS/IFN-gamma-treated M1 RAW264.7 cells and IL-4/IL-13-treated …
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