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Effect of Cu- and Fe- Isolated from Environmental Particulate Matter on Mitochondrial Dynamics in Human Colon CaCo-2 Cells
Publication Year: 2025 Source: Biol Trace Elem Res PMID: 39738852
No Abstract
Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review
Publication Year: 2025 Source: Pain Ther PMID: 39738973
No Abstract
Myeloid-Derived Suppressor Cell Accumulation Drives Intestinal Fibrosis through mCCL6/hCCL15 Chemokine-Mediated Fibroblast Activation
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39739231 DOI: 10.1002/advs.202411711
Intestinal fibrosis, a severe complication of Crohn's disease (CD), is linked to chronic inflammation, but the precise mechanism by which immune-driven intestinal inflammation leads to fibrosis development is not fully understood. This study investigates the role of myeloid-derived suppressor cells (MDSCs) in intestinal fibrosis in CD patients and a 2,4,6-trinitrobenzene …
Novel Naphthyridones Targeting Pannexin 1 for Colitis Management
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39739600 DOI: 10.1002/advs.202411538
Pannexin 1 (PANX1) forms cell-surface channels capable of releasing signaling metabolites for diverse patho-physiological processes. While inhibiting dysregulated PANX1 has been proposed as a therapeutic strategy for many pathological conditions, including inflammatory bowel disease (IBD), low efficacy, or poor specificity of classical PANX1 inhibitors introduces uncertainty for their applications in …
Histologic and Endoscopic Findings Are Highly Correlated in a Prospective Cohort of Patients With Inflammatory Bowel Diseases
Publication Year: 2025 Source: J Crohns Colitis PMID: 39739605
BACKGROUND AND AIMS: The advantages of endoscopic vs histologic assessments of inflammation in inflammatory bowel disease remain unclear. We compared endoscopic and histologic inflammation in a prospective cohort. Furthermore, in patients with discordant findings, we compared the ability of endoscopy vs histology to predict disease course. METHODS: Ulcerative colitis (UC) …
The Gut Microbiota Affects Anti-TNF Responsiveness by Activating the NAD(+) Salvage Pathway in Ulcerative Colitis
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39739648
No Abstract
Characterization of Active Compounds in Sanhuang Shu'ai Decoction for the Management of Ulcerative Colitis: A UHPLC-MS Study
Publication Year: 2025 Source: Rapid Commun Mass Spectrom PMID: 39740112
OBJECTIVE: The effectiveness of Sanhuang Shu'ai decoction (SSD), a traditional Chinese medicine used to treat diarrhea and colitis, especially ulcerative colitis (UC), is not well understood regarding how its chemical components work. METHODS: This research used ultra-high-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS), network pharmacology, and molecular docking to understand …
An exploratory multi-omics study reveals distinct molecular signatures of ulcerative colitis and Crohn's disease and their correlation with disease activity
Publication Year: 2025 Source: J Pharm Biomed Anal PMID: 39740478 DOI: 10.1016/j.jpba.2024.116652
Clinically heterogeneous spectrum and molecular phenotypes of inflammatory bowel disease (IBD) remain to be comprehensively elucidated. This exploratory multi-omics study investigated the serum molecular profiles of Crohn's disease (CD) and ulcerative colitis (UC), in association with elevated fecal calprotectin and disease activity states. The serum proteome, metabolome, and lipidome of …
Microbiome and Mucosal Immunity in the Intestinal Tract
Publication Year: 2025 Source: In Vivo PMID: 39740876
The human bowel is exposed to numerous biotic and abiotic external noxious agents. Accordingly, the digestive tract is frequently involved in malfunctions within the organism. Together with the commensal intestinal flora, it regulates the immunological balance between inflammatory defense processes and immune tolerance. Pathological changes in this system often cause …
NRP1 instructs IL-17-producing ILC3s to drive colitis progression
Publication Year: 2025 Source: Cell Mol Immunol PMID: 39741194 DOI: 10.1038/s41423-024-01246-7
Group 3 innate lymphoid cells (ILC3s) control tissue homeostasis and orchestrate mucosal inflammation; however, the precise mechanisms governing ILC3 activity are fully understood. Here, we identified the transmembrane protein neuropilin-1 (NRP1) as a positive regulator of interleukin (IL)-17-producing ILC3s in the intestine. NRP1 was markedly upregulated in intestinal mucosal biopsies …
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