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Meta-Analysis: Prevalence of Frailty and Associated Adverse Events in Inflammatory Bowel Diseases
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39524008 DOI: 10.1111/apt.18390
BACKGROUND: The number of adults aged over 60 years with inflammatory bowel disease (IBD) is increasing. Frailty, rather than chronological age, may be a better predictor of adverse health outcomes. AIMS: To summarise current knowledge about frailty in adults with IBD including the prevalence and associations of frailty and IBD-related …
The holistic management of peripheral spondyloarthritis: focus on articular involvement in patients with inflammatory bowel disease
Publication Year: 2025 Source: Reumatismo PMID: 39526478 DOI: 10.4081/reumatismo.2024.1688
OBJECTIVE: To provide a comprehensive overview of peripheral spondyloarthritis (pSpA), focusing specifically on its occurrence and management in patients with inflammatory bowel disease (IBD). METHODS: An exhaustive literature search was conducted in PubMed, Embase, Cochrane Database of Systematic Reviews, and Google Scholar to identify relevant studies on pSpA in IBD …
The Underlying Causes of Secondary Bile Acid Diarrhea May Confound Cancer Risk
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39526660
No Abstract
Response to Wei-Zhen Tang et al
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39526663 DOI: 10.14309/ajg.0000000000003149
No Abstract
Fatigue in Patients with Inflammatory Bowel Disease in Remission One Year After Diagnosis (the IBSEN III Study)
Publication Year: 2025 Source: J Crohns Colitis PMID: 39527064
BACKGROUND AND AIMS: Fatigue is commonly observed in Crohn's disease (CD) and ulcerative colitis (UC) but its association to achieving remission is not clearly established. In this study, we describe the odds for fatigue in patients with CD/UC 1 year after diagnosis based on different definitions of remission and identified …
Methods for Selective Gene Expression Profiling in Single Tertiary Lymphoid Structure Using Laser Capture Microdissection
Publication Year: 2025 Source: Methods Mol Biol PMID: 39527219
Tertiary lymphoid structures (TLS) are de novo lymphoid formations that are induced within tissues during inflammatory episodes. TLS have been reported at various anatomic sites and in many different contexts like cancer, infections, autoimmunity, graft rejection, and idiopathic diseases. These inducible, ectopic, and transient lymphoid structures exhibit the prototypical architecture …
Dual action tofacitinib-loaded PLGA nanoparticles alleviate colitis in an IBD mouse model
Publication Year: 2025 Source: Drug Deliv Transl Res PMID: 39527394 DOI: 10.1007/s13346-024-01736-1
Inflammatory bowel disease (IBD) affects over 7 million people worldwide and significant side effects are associated with current therapies such as tofacitinib citrate (TFC), which is linked to increased risks of malignancy and congestive heart issues. To mitigate these systemic adverse effects, localised drug delivery via nano-sized carriers to inflamed …
Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39527499 DOI: 10.1093/ibd/izae262
BACKGROUND: Crohn's disease (CD) is a major form of inflammatory bowel disease (IBD) which has relapsing and remitting symptoms. Better ways to detect and monitor active disease are required for early diagnosis and optimal outcomes. We assessed fecal myeloperoxidase (fMPO), a neutrophil-derived enzyme that produces hypochlorous acid, as a marker …
Myosteatosis Evaluated Based on Intramuscular Adipose Tissue Content Is a Risk Factor for Postoperative Complications in Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39527569
BACKGROUND: Crohn's disease causes acute and chronic inflammation that often make the preoperative evaluation of surgical risks difficult. Myosteatosis is used for the evaluation of muscle quality to assess sarcopenia. However, data on the relationship between myosteatosis and surgical outcomes in patients with Crohn's disease are lacking. METHODS: Among patients …
Use of Modified Multiplier of the Simple Endoscopic Score for Crohn's Disease Endoscopic Improvement Thresholds Enhances Effect Size Differentiation Between Adalimumab Versus Placebo: A Post Hoc Analysis of the EXTEND Trial
Publication Year: 2025 Source: J Crohns Colitis PMID: 39529369
INTRODUCTION: The Modified Multiplier of the Simple Endoscopic Score for Crohn's Disease (MM-SES-CD) refines the assessment of endoscopic CD severity by differentially weighting parameters in the original SES-CD. A threshold of <22.5 for MM-SES-CD suggests endoscopic remission (ER) and correlates with a low risk of long-term disease progression. This study …
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