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Psychometric evaluation of the Functional Assessment of chronic illness therapy-fatigue (FACIT-Fatigue) in adults with moderately to severely active Crohn's disease
Publication Year: 2025 Source: Qual Life Res PMID: 39537976
No Abstract
Upadacitinib is associated with clinical response and steroid-free remission for children and adolescents with inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39538977 DOI: 10.1002/jpn3.12408
OBJECTIVE: Upadacitinib, an oral Janus kinase inhibitor (JAKi), is approved for inflammatory bowel disease (IBD) in adults. As on-label use will face significant delay in pediatrics, a real-world understanding of safety and efficacy in children is critical. METHODS: This is a single-center retrospective cohort of pediatric subjects (ages 9-20 years) …
Epimedium polysaccharides ameliorate ulcerative colitis by inhibiting oxidative stress and regulating autophagy
Publication Year: 2025 Source: J Sci Food Agric PMID: 39540346
No Abstract
Factors Associated With Biologic Therapy After Ileal Pouch-Anal Anastomosis in Patients With Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39540419
BACKGROUND: Patients with ulcerative colitis (UC) undergoing proctocolectomy and ileal pouch-anal anastomosis (IPAA) may eventually require biologic therapy. Factors associated with biologic therapy after IPAA have not been previously studied. METHODS: All patients with UC after total proctocolectomy and IPAA who were followed at Rabin Medical Center comprehensive pouch clinic …
Why Symptoms Linger in Quiescent Crohn's Disease: Investigating the Impact of Sulfidogenic Microbes and Sulfur Metabolic Pathways
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39541261 DOI: 10.1093/ibd/izae238
INTRODUCTION: Even in the absence of inflammation, persistent symptoms in patients with Crohn's disease (CD) are prevalent and worsen quality of life. We previously demonstrated enrichment in sulfidogenic microbes in quiescent Crohn's disease patients with (qCD + S) vs without persistent GI symptoms (qCD-S). Thus, we hypothesized that sulfur metabolic …
Comment on: "The Burden of Psychiatric Manifestations in Inflammatory Bowel Diseases: A Systematic Review With Meta-analysis"
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39541571
No Abstract
Integrative multi-omics analysis of Crohn's disease and metabolic syndrome: Unveiling the underlying molecular mechanisms of comorbidity
Publication Year: 2025 Source: Comput Biol Med PMID: 39541897
No Abstract
Folic acid-based hydrogels co-assembled with protocatechuic acid for enhanced treatment of inflammatory bowel disease
Publication Year: 2025 Source: Colloids Surf B Biointerfaces PMID: 39541908 DOI: 10.1016/j.colsurfb.2024.114367
Inflammatory bowel disease (IBD) presents a significant therapeutic challenge due to the need for oral drug delivery systems that withstand acidic environment of stomach while effectively targeting intestinal inflammation. To address this issue, we created a novel hydrogel system based on a folic acid (FA)-dopamine (DA) conjugate, co-assembled with protocatechuic …
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Publication Year: 2025 Source: Cell Mol Immunol PMID: 39543372
No Abstract
The Nancy Histopathological Index has limited value in predicting clinical outcomes in newly diagnosed pediatric patients with ulcerative colitis
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39543954
No Abstract
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