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Paradoxical psoriasiform skin eruption in paediatric patients with inflammatory bowel disease treated with tumour necrosis factor-α inhibitors
Publication Year: 2025 Source: Clin Exp Dermatol PMID: 39400046 DOI: 10.1093/ced/llae432
BACKGROUND: Tumour necrosis factor alpha (TNF-alpha) inhibitor (TNFi)-induced psoriasiform eruptions are a well-known phenomenon among adults. However, data are limited regarding this reaction in children. OBJECTIVES: To describe in paediatric patients with inflammatory bowel disease (IBD) the clinical characteristics of TNFi-induced psoriasiform eruptions and the outcomes of various therapeutic options. …
Therapeutic targets for gastrointestinal diseases: proteome-wide Mendelian randomization and colocalization analyses
Publication Year: 2025 Source: Postgrad Med J PMID: 39400547
PURPOSE: This study was aimed to identify serum proteins linked with gastrointestinal diseases by proteome-wide Mendelian randomization analysis. METHODS: We determined the casual relationship between 732 kinds of circulating proteins and the 24 kinds of gastrointestinal diseases via Mendelian randomization analysis. RESULTS: Four circulating proteins (FCGR3B, IL-12B, MAPKAPK2, and IL-23R) …
Novel mouse model for studying transmural intestinal fibrosis and creeping fat formation in stricturing Crohn's disease
Publication Year: 2025 Source: Gut PMID: 39401871 DOI: 10.1136/gutjnl-2024-333590
No Abstract
Association between hospital type and length of stay and readmissions for young adults with complex chronic diseases
Publication Year: 2025 Source: J Hosp Med PMID: 39404149 DOI: 10.1002/jhm.13524
BACKGROUND: There is a paucity of information around whether hospital length of stay and readmission rates differ based upon hospital type for adolescents and young adults (AYA) with complex chronic diseases (CCDs). OBJECTIVE: To measure the association between hospital type and readmission rates and index admission LOS among AYA with …
Mucosal Cytokine Expression Associated With Deep Endoscopic Mucosal Healing in Ulcerative Colitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 39412247
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of unknown cause, for which no curative treatments have been developed. Cytokines play an important role in the pathogenesis of UC, and therapies targeting specific cytokines have been successful in treating refractory UC. The purpose of this study was to measure …
Unmasking the Steroid Curtain: Reevaluating Corticosteroid Use in IBD Clinical Trials
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39413112 DOI: 10.1093/ibd/izae245
No Abstract
Placebo Rates in Crohn's Disease Randomized Clinical Trials: An Individual Patient Data Meta-Analysis
Publication Year: 2025 Source: Gastroenterology PMID: 39414161
No Abstract
Investigate the metabolic changes in intestinal diseases by employing a (1)H-NMR-based metabolomics approach on Caco-2 cells treated with cedrol
Publication Year: 2025 Source: Biofactors PMID: 39415440 DOI: 10.1002/biof.2132
Mitochondrial dysfunction may precipitate intestinal dysfunction, while inflammatory bowel disease manifests as a chronic inflammatory ailment affecting the gastrointestinal tract. This condition disrupts the barrier function of the intestinal epithelium and alters metabolic products. Increasing mitochondrial adenosine triphosphate (ATP) synthesis in intestinal epithelial cells presents a promising avenue for colitis …
Efficacy of vedolizumab and ustekinumab in pediatric-onset inflammatory bowel disease: A real-world multicenter study
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39415517 DOI: 10.1002/jpn3.12384
OBJECTIVES: Vedolizumab and ustekinumab are effective in inducing and maintaining corticosteroid-free clinical remission (CFR) in adult patients with inflammatory bowel disease (IBD). This study describes the efficacy and safety of vedolizumab and ustekinumab in pediatric IBD. METHODS: All patients </=18 years of age with Crohn's disease (CD) or ulcerative colitis …
Neuro-immune cell interactions in the regulation of intestinal immune homeostasis
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 39417780
No Abstract
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