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Chemical Basis and Molecular Mechanism of Aged Qingzhuan Tea Alleviating DSS-Induced Colitis
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 39676441 DOI: 10.1002/mnfr.202400734
SCOPE: Inflammatory bowel disease (IBD) poses a serious threat to human health. Qingzhuan tea (QZT), especially aged QZT, was concerned to have a potential effect on the prevention of colitis. In this study, we aim to assess the feasibility of different aged QZT on the alleviation of colitis induced by …
Association Between Biologics and Janus Kinase Inhibitors With Inflammatory Bowel Disease as Paradoxical Reactions: A Real-World Assessment
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39676727 DOI: 10.1002/ueg2.12719
BACKGROUND AND OBJECTIVE: With limited evidence connecting paradoxical inflammatory bowel disease (paradoxical IBD) to the newest biologics and Janus kinase inhibitors, our study aims to investigate the occurrence of paradoxical IBD induced by these agents in treating other immune-mediated inflammatory diseases (IMIDs). We aim to identify associated risk signals, the …
Multiple Ileal and Colonic Stenoses: Is It Always Crohn's Disease?
Publication Year: 2025 Source: J Crohns Colitis PMID: 39679549
A 62-year-old woman presented with multiple ileal and colonic stenoses, initially suspected to be Crohn's disease. Despite unremarkable endoscopic biopsies, surgery was performed due to clinical deterioration, and histological analysis confirmed the presence of metastatic breast cancer. This case highlights the importance of considering metastatic disease in the differential diagnosis …
Clinical relevance of calprotectin in patients with perianal fistulas in Crohn's disease and cryptoglandular fistulas
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39680482 DOI: 10.1002/ueg2.12622
BACKGROUND AND AIMS: Previous literature suggests that faecal calprotectin (FC) discriminates Crohn's disease perianal fistulas from cryptoglandular fistulas, irrespective of luminal disease. This study aims to prospectively validate this and analyse if increased local fistula calprotectin levels are associated with fistula characteristics. METHODS: In this prospective study, all consecutive patients …
New Insights into the Pathogenesis of Intestinal Fibrosis in Inflammatory Bowel Diseases: Focusing on Intestinal Smooth Muscle Cells
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39680685 DOI: 10.1093/ibd/izae292
Strictures in inflammatory bowel disease, especially Crohn's disease (CD), are characterized by increased intestinal wall thickness, which, according to recent accumulating data, is mainly attributed to the expansion of the intestinal smooth muscle layers and to a lesser extent to collagen deposition. In this review, we will discuss the role …
Biogeographical distribution of gut microbiome composition and function is partially recapitulated by fecal transplantation into germ-free mice
Publication Year: 2025 Source: ISME J PMID: 39680691
Fecal microbiota transplantation has been vital for establishing whether host phenotypes can be conferred through the microbiome. However, whether the existing microbial ecology along the mouse gastrointestinal tract can be recapitulated in germ-free mice colonized with stool remains unknown. We first identified microbes and their predicted functions specific to each …
Acute Severe Ulcerative Colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39681225
No Abstract
Synergistic interactions between gut microbiota and short chain fatty acids: Pioneering therapeutic frontiers in chronic disease management
Publication Year: 2025 Source: Microb Pathog PMID: 39681288
No Abstract
Publication bias in studies on biologic therapy for children with inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39686553 DOI: 10.1002/jpn3.12433
OBJECTIVE: The utilization of biologic drugs in children with inflammatory bowel disease (IBD) surged following the publications of positive results in randomized controlled trials and real-world studies. We aimed to explore the extent of publication bias associated with these findings. METHODS: Two reviewers assessed all abstracts evaluating the efficacy or …
The Pouch Corner: Perianal Fistulas and Ileal Pouches: Examining Fistulas Before and After Pouch Creation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39418335
No Abstract
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