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Investigation of the Chemical Composition and Biological Activities of Eremurus spectabilis M. Bieb through Antioxidant, Enzyme Inhibition, COX-2and iNOS Assessment

Publication Year: 2025 Source: Chem Biodivers PMID: 39435847

No Abstract

Post-Discharge Outcomes of Elderly Patients Hospitalized for Inflammatory Bowel Disease Flare Complicated by Clostridioides difficile Infection

Publication Year: 2025 Source: J Crohns Colitis PMID: 39435855 DOI: 10.1093/ecco-jcc/jjae161

OBJECTIVES: Elderly hospitalized patients with inflammatory bowel disease (IBD) flare and concurrent Clostridioides difficile infection (CDI) are considered at high risk of IBD-related complications. We aimed to evaluate the short-,intermediate-, and long-term post-discharge complications among these patients. METHODS: A retrospective multicenter cohort study assessing outcomes of elderly individuals (>/=60 years) …

Incidence of Thiopurine-Induced Severe Myelosuppression in a Nationwide Cohort of Patients With Inflammatory Bowel Disease

Publication Year: 2025 Source: Am J Gastroenterol PMID: 39436267 DOI: 10.14309/ajg.0000000000003141

INTRODUCTION: There is paucity of data on the incidence of severe thiopurine (TP)-induced myelosuppression (TIM) among patients with inflammatory bowel disease (IBD). METHODS: Using the Veterans Affairs Healthcare System, we identified patients with IBD with normal pretreatment TP S-methyltransferase levels who received TPs for 6 months and developed severe TIM. …

Circulating Extracellular Matrix Products as Indicators of Disease Burden and Predictors of Disease Course in Ulcerative Colitis

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39437199

BACKGROUND: Ulcerative colitis (UC) is characterized by recurrent inflammation and challenging disease monitoring, with invasive endoscopy as the primary diagnostic tool despite the inadequacy of standard noninvasive biomarkers. This study evaluates serum extracellular matrix (ECM) fragments, which reflect the remodeling of mucosa and submucosa, as potential indicators of disease burden …

Risankizumab Is Effective for the Management of Crohn's Disease of the Pouch

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39437342

No Abstract

GLP-1 Receptor Agonists Confer No Increased Rates of IBD Exacerbation Among Patients With IBD

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39438251 DOI: 10.1093/ibd/izae250

BACKGROUND: In patients with inflammatory bowel disease (IBD), multimorbidity with obesity and type 2 diabetes is common and increasing. Glucagon-like peptide 1 (GLP-1) receptor agonists are increasingly being prescribed for patients with IBD, yet their impact on patients with IBD is largely unknown. We aimed to assess the impact of …

Microbial and Transcriptomic Landscape Associated With Neutrophil Extracellular Traps in Perianal Fistulizing Crohn's Disease

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39438255

BACKGROUND: Perianal fistulizing Crohn's disease (pfCD) poses significant healing challenges, closely associated with neutrophil extracellular traps (NETs). This study aimed to investigate the microbe-host interactions influencing NETs in pfCD. METHODS: From January 2019 to July 2022, patients with pfCD were screened at Ren Ji Hospital. Patients in remission following comprehensive …

Tryptophan Metabolites Improve Intestinal Mucosal Barrier via the Aryl Hydrocarbon Receptor-Interleukin-22 Pathway in Murine Dextran Sulfate Sodium-Induced Pouchitis

Publication Year: 2025 Source: Dis Colon Rectum PMID: 39440869

No Abstract

Ulcerative colitis in the elderly

Publication Year: 2025 Source: Intern Emerg Med PMID: 39441498

No Abstract

GLP-1 Analog Use is Associated With Improved Disease Course in Inflammatory Bowel Disease: A Report from the Epi-IIRN

Publication Year: 2025 Source: J Crohns Colitis PMID: 39441993 DOI: 10.1093/ecco-jcc/jjae160

BACKGROUND AND AIMS: The growing use of glucagon-like peptide 1 (GLP-1) analogs for type 2 diabetes mellitus (DM2) and obesity necessitates studies about their use in patients with inflammatory bowel diseases (IBD). METHODS: Data on patients with DM2 were retrieved from an Israeli nationwide cohort of patients with IBD (epi-IIRN), …

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