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Immune Dysregulation in a Child With SOD1-Related Neurological Disease
Publication Year: 2025 Source: Am J Med Genet A PMID: 39629626
No Abstract
Bioelectronic Medicines-A Novel Approach of Therapeutics in Current Epoch
Publication Year: 2025 Source: Curr Pharm Des PMID: 39313906
BACKGROUND: Bioelectronic medicines aim to diagnose and treat a wide range of illnesses and ailments, including cancer, rheumatoid arthritis, inflammatory bowel disease, obesity, diabetes, asthma, paralysis, blindness, bleeding, ischemia, organ transplantation, cardiovascular disease, and neurodegenerative diseases. The focus of bioelectronic medicine is on electrical signaling of the nervous system. Understanding …
Translational characterization of immune pathways in inflammatory bowel disease: insights for targeted treatments
Publication Year: 2025 Source: Expert Rev Clin Immunol PMID: 39313992 DOI: 10.1080/1744666X.2024.2400300
INTRODUCTION: The pathogenesis of inflammatory bowel disease (IBD) involves the dysregulation of multiple inflammatory pathways. The understanding of these mechanisms allows their selective targeting for therapeutic purposes. The discovery of Tumor Necrosis Factor-alpha's (TNF-alpha) role in mucosal inflammation ushered an exciting new era of drug development which now comprises agents …
Anti-Tumor Necrosis Factor Therapy and the Risk of Gestational Diabetes in Pregnant Women With Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39315687 DOI: 10.14309/ajg.0000000000003100
INTRODUCTION: Anti-tumor necrosis factor (anti-TNF) therapy may improve insulin sensitivity, and its impact during pregnancy remains unclear. We aimed to assess the risk of gestational diabetes mellitus (GDM) associated with anti-TNF treatment among pregnant women with inflammatory bowel disease (IBD). METHODS: This nationwide cohort study included patients with IBD in …
The Impact of Group Cognitive Behavioral Psychotherapy on Disease Severity and Psychosocial Functioning in Patients With Inflammatory Bowel Disease: A Randomized Controlled Study
Publication Year: 2025 Source: J Crohns Colitis PMID: 39316575 DOI: 10.1093/ecco-jcc/jjae144
BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) often report symptoms of anxiety and depression as well as impaired quality of life (QoL). To date, there are few studies on the effect of psychotherapy on psychological functioning and clinical outcome in patients with IBD. The aim of this prospective, …
Efficacy and Safety of Etrasimod in Patients with Ulcerative Colitis in Japan: Data from the Phase 3 ELEVATE UC 12 and ELEVATE UC 40 JAPAN Trials
Publication Year: 2025 Source: Digestion PMID: 39317165
No Abstract
Healthcare Utilization and Geographic Distribution of Advanced Therapy in Minority Race and Ethnic Groups With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39321098 DOI: 10.1093/ibd/izae219
BACKGROUND AND AIMS: Biases in healthcare pose challenges for inflammatory bowel disease (IBD) patients from underrepresented races and ethnicities. Our study aimed to assess the quality of and access to care among underrepresented racial and ethnic populations using a diverse database. METHODS: We used the OneFlorida Data Trust, representing over …
Pediatric Inflammatory Bowel Disease Type Unclassified: A Nationwide Cohort Study in Scotland With up to 20 Years Follow-up Shows Reclassification in the Majority and Mild Course in Those Whose Diagnosis Is Unchanged
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39321100
BACKGROUND: Given the paucity of long-term longitudinal data for inflammatory bowel disease type unclassified (IBDU), we aimed to clarify IBDU disease course and reclassification rate by presenting nationwide data with up to 20 years of follow-up. METHODS: We analyzed a prospectively identified 11-year cohort of pediatric patients diagnosed with IBDU …
Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39321109 DOI: 10.1093/ibd/izae232
Intestinal epithelial tight junctions (TJs), a dynamically regulated barrier structure composed of occludin and claudin family of proteins, mediate the interaction between the host and the external environment by allowing selective paracellular permeability between the luminal and serosal compartments of the intestine. TJs are highly dynamic structures and can undergo …
Correction to: Consensus Statement on Managing Anxiety and Depression in Individuals with Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39321448
No Abstract
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