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Targeted V-type peptide-decorated nanoparticles prevent colitis by inhibiting endosomal TLR signaling and modulating intestinal macrophage polarization

Publication Year: 2025 Source: Biomaterials PMID: 39321686 DOI: 10.1016/j.biomaterials.2024.122843

Inflammatory bowel disease (IBD) has become a serious and challenging health problem globally without curative medical treatments. Mounting evidence suggests that intestinal macrophages and their phenotypes are key players in the pathogenesis of IBD. Modulating the phenotypes and functions of intestinal macrophages through targeted interventions could be a promising approach …

Culturally Sensitive and Inclusive IBD Care

Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39321949 DOI: 10.1016/j.cgh.2024.06.052

As the prevalence of inflammatory bowel disease (IBD) increases within historically disadvantaged communities, it is imperative to better understand how intersectionality-defined as the complex, cumulative way in which the effects of multiple forms of discrimination (such as racism, sexism, and classism)-intersects and social determinants of health influence the patient's experiences …

Mirikizumab for the treatment of chronic antibiotic-refractory pouchitis

Publication Year: 2025 Source: Z Gastroenterol PMID: 39321965

No Abstract

Incidence and risk factors for thromboembolic events in pediatric-onset inflammatory bowel disease: A French population-based study

Publication Year: 2025 Source: Dig Liver Dis PMID: 39322448 DOI: 10.1016/j.dld.2024.09.005

INTRODUCTION: Patients with inflammatory bowel disease (IBD) are at higher risk of thromboembolic events (TE). In pediatric-onset IBD, more data on incidence and risk factors of venous (VTE) and arterial events (ATE) at the population level are needed to guide thromboprophylaxis. METHODS: All patients aged </= 16 years diagnosed with …

Cancer Characteristics, Prognoses, and Mortality of Colorectal Cancer in Patients With Crohn's Disease-A Danish Nationwide Cohort Study, 2009-2019

Publication Year: 2025 Source: J Crohns Colitis PMID: 39324656

BACKGROUND AND AIMS: The aim of this study was to investigate the impact of Crohn's disease (CD) on patient and cancer characteristics and mortality in patients with colorectal cancer (CRC). METHODS: This was a nationwide cohort study of patients diagnosed with CRC in Denmark from 1 January, 2009 to 31 …

Pregnancy outcomes in Greek women with inflammatory bowel disease: a longitudinal national retrospective study

Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39324945 DOI: 10.1097/MEG.0000000000002844

BACKGROUND: Inflammatory bowel disease (IBD) commonly affects patients of reproductive age. The effect of disease activity on the outcome of pregnancy and its impact on neonatal health are areas of intense research. METHODS: Alpha national retrospective study of pregnancies in women with IBD between 2010 and 2020 was carried out …

Long Rectal Cuff and Remnant Mesorectum Are Major Preventable Causes of Ileal Pouch Failure

Publication Year: 2025 Source: Dis Colon Rectum PMID: 39325029

No Abstract

Health-Related Quality of Life Outcomes With Etrasimod Treatment in Patients With Ulcerative Colitis: A Post Hoc Analysis of Data From ELEVATE UC 52 and ELEVATE UC 12

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39326009

BACKGROUND: Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). Here, we evaluate the impact of etrasimod 2 mg QD on health-related quality of life (HRQoL) in patients with UC. METHODS: This post hoc analysis used data …

Efficacy and Safety of Upadacitinib for Perianal Fistulizing Crohn's Disease: A Post Hoc Analysis of 3 Phase 3 Trials

Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39326583

No Abstract

Addressing Additional Limitations in the Study on Small Intestine Cancer Risk in Patients With Inflammatory Bowel Disease

Publication Year: 2025 Source: Am J Gastroenterol PMID: 39329390

No Abstract

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