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The Intestinal Mucin Isoform Landscape Reveals Region-Specific Biomarker Panels for Inflammatory Bowel Disease Patient Stratification
Publication Year: 2025 Source: J Crohns Colitis PMID: 39330996 DOI: 10.1093/ecco-jcc/jjae155
BACKGROUND AND AIMS: Mucosal healing is considered a key therapeutic endpoint in inflammatory bowel diseases (IBD) and comprises endoscopic improvement of inflammation without taking barrier healing into account. Mucins are critical components of the mucosal barrier function that give rise to structurally diverse isoforms. Unraveling disease-associated mucin isoforms that could …
Effects of an Extract of Physalis Peruviana Linnaeus on the Expression of Inflammatory Markers in the Caco-2 Intestinal Epithelium-like Cell Line
Publication Year: 2025 Source: J Am Nutr Assoc PMID: 39331669 DOI: 10.1080/27697061.2024.2406896
Objective: Physalis Peruviana Linnaeus (PPL) is an herbaceous species characterized by a wide variety of bioactive compounds to which anti-inflammatory properties have been attributed. This makes this fruit a possible complementary therapy for diseases that involve chronic inflammation, such as inflammatory bowel diseases (IBD). In the present study, the effect …
It Runs in the Family: What Studying Unaffected Individuals in Simplex and Multiplex Families Tells Us About Inflammatory Bowel Disease Development
Publication Year: 2025 Source: Gastroenterology PMID: 39332605
No Abstract
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes
Publication Year: 2025 Source: Mucosal Immunol PMID: 39332767 DOI: 10.1016/j.mucimm.2024.09.004
Inflammatory bowel disease (IBD) chronicity results from memory T helper cell (Tmem) reactivation. Identifying patient-specific immunotypes is crucial for tailored treatment. We conducted a comprehensive study integrating circulating immune proteins and circulating Tmem, with intestinal tissue histology and mRNA analysis, in therapy-naive pediatric IBD (Crohn's disease, CD: n = 62; …
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner
Publication Year: 2025 Source: Mucosal Immunol PMID: 39332768 DOI: 10.1016/j.mucimm.2024.09.005
Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In various mouse models of IBD, we and …
A Review of Cutaneous Extraintestinal Manifestations of Inflammatory Bowel Disease in Skin of Color
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39340819 DOI: 10.1093/ibd/izae222
The incidence of inflammatory bowel disease (IBD) is increasing in racial and ethnic minority groups. Cutaneous extraintestinal manifestations (EIMs) of IBD are well-known comorbid conditions that can occur in both active and quiescent IBD. Historically, cutaneous EIMs of IBD are described in White skin with a lack of literature describing …
Targeting NCAPD2 as a Therapeutic Strategy for Crohn's Disease: Implications for Autophagy and Inflammation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39340820
BACKGROUND: Our earlier studies identified that non-SMC condensin I complex subunit D2 (NCAPD2) induces inflammation through the IKK/NF-kappaB pathway in ulcerative colitis. However, its role in the development of Crohn's disease (CD) and the specific molecular mechanism still need to be further studied. METHODS: NCAPD2 expression in clinical ileal CD …
Challenges in the Management of Acute Severe Ulcerative Colitis in a Patient With Guillain-Barré Syndrome Associated With Infliximab
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39340824
No Abstract
Antiphospholipid syndrome autoantibodies induction after treatment with anti-TNF alpha therapy in patients with IBD
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39341406 DOI: 10.1016/j.gastrohep.2024.502258
INTRODUCTION: Ant-iTNF treatment has been broadly linked with autoantibodies and autoimmune disorders development. After the clinical observation of aPTT (activated partial thromboplastin clotting time) prolongation in our cohort of IBD patients treated with anti-TNF, we sought to determine the presence of antiphospolipid antibodies in our population, along with antiphospholipid syndrome …
Repeated endoscopic dilation and needle-knife stricturotomy for Crohn's disease strictures
Publication Year: 2025 Source: Gastrointest Endosc PMID: 39343051
No Abstract
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