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Bacterial metabolomics: current applications for human welfare and future aspects
Publication Year: 2025 Source: J Asian Nat Prod Res PMID: 39078342
No Abstract
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39078887
BACKGROUND: Intestinal fibrosis, a complex complication of colitis, is characterized by excessive extracellular matrix (ECM) deposition. Estrogen receptor (ER) beta may play a role in regulating this process. METHODS: Intestinal tissue samples from stenotic and nonstenotic regions were collected from Crohn's disease (CD) patients. RNA sequencing was conducted on a …
Explorative study on the value of hepcidin in predicting iron non-responsiveness in paediatric inflammatory bowel disease
Publication Year: 2025 Source: Pediatr Res PMID: 39080460 DOI: 10.1038/s41390-024-03375-1
BACKGROUND: In a considerable proportion of anaemic children with inflammatory bowel disease (IBD), haemoglobin (Hb) does not normalise after iron therapy. We evaluated the added value of novel iron markers (hepcidin and soluble transferrin receptor [sTfR]) as compared to traditional iron markers (ferritin and transferrin saturation [TSAT]) to determine the …
The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn's Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39126198
BACKGROUND AND AIMS: During early phases of inflammation, activated neutrophils extrude neutrophil extracellular traps (NETs) in a peptidyl arginine deiminase 4 (PAD4)-dependent manner, aggravating tissue injury and remodeling. In this study, we investigated the potential pro-fibrotic properties and signaling of NETs in Crohn's disease (CD). METHODS: NETs and activated fibroblasts …
Changes in Endoscopic Activity and Classification of Lesions With Panenteric Capsule Endoscopy in Patients Treated for Crohn's Disease-A Prospective Blinded Comparison With Ileocolonoscopy, Fecal Calprotectin, and C-Reactive Protein
Publication Year: 2025 Source: J Crohns Colitis PMID: 39126260
BACKGROUND AND AIMS: Panenteric capsule endoscopy (PCE) is a minimally invasive modality that may replace ileocolonoscopy (IC) in selected patients with Crohn's disease (CD). This study aimed to evaluate the dynamics of repeated assessment with PCE in patients receiving medical treatment for ileocolonic CD. METHODS: This prospective, blinded, multicenter study …
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 39126385 DOI: 10.1093/ecco-jcc/jjae125
BACKGROUND AND AIMS: While there is increasing interest in microbiome-directed therapies for patients with ulcerative colitis (UC), the identification of microbial targets remains elusive, underlining the need for novel approaches. METHODS: Utilizing metagenomic data from the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD), available …
Benefit-Risk Trade-offs and Patient Preferences for Therapy Selection in Ulcerative Colitis: a Multicountry Preference Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39126434
BACKGROUND: To help navigate the complex treatment landscape of ulcerative colitis (UC), we quantified the benefit-risk trade-offs that patients were willing to make when choosing treatment. METHODS: Patients completed an online discrete choice experiment. Eligible patients had a UC diagnosis for >/=6 months, were aged >/=18 years, and resided in …
Developing a Machine-Learning Prediction Model for Infliximab Response in Crohn's Disease: Integrating Clinical Characteristics and Longitudinal Laboratory Trends
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39126463 DOI: 10.1093/ibd/izae176
BACKGROUND: Achieving long-term clinical remission in Crohn's disease (CD) with antitumor necrosis factor alpha (anti-TNF-alpha) agents remains challenging. AIMS: This study aims to establish a prediction model based on patients' clinical characteristics using a machine-learning approach to predict the long-term efficacy of infliximab (IFX). METHODS: Three cohorts comprising 746 patients …
Perianal Fistulizing Crohn's Disease: Utilizing the TOpClass Classification in Clinical Practice to Provide Targeted Individualized Care
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39134293 DOI: 10.1016/j.cgh.2024.06.047
BACKGROUND & AIMS: Perianal fistulation is a challenging phenotype of Crohn's disease, with significant impact on quality of life. Historically, fistulae have been classified anatomically in relation to the sphincter complex, and management guidelines have been generalized, with lack of attention to the clinical heterogenicity seen. The recent 'TOpClass classification …
Comparative Efficacy of Biologics and Small Molecule Therapies in Improving Patient-Reported Outcomes in Ulcerative Colitis: Systematic Review and Network Meta-Analysis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39137239 DOI: 10.1093/ibd/izae163
BACKGROUND: Ulcerative colitis (UC) is a chronic disorder with a considerable negative impact on health-related quality of life (HRQoL), which has been recently recognized as an important treatment target. The purpose of this study is to compare the efficacy of different biologics and small molecule therapies in achieving better patient-reported …
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