Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Atom-Efficient Synthesis of Trimethine Cyanines Using Formaldehyde as a Single-Carbon Source
Publication Year: 2025 Source: Angew Chem Int Ed Engl PMID: 39291296 DOI: 10.1002/anie.202413121
Herein, we present an innovative and atom-efficient synthesis of trimethine cyanines (Cy3) using formaldehyde (FA) as a single-carbon reagent. The widespread application of Cy3 dyes in bioimaging and genomics/proteomics is often limited by synthetic routes plagued by low atom economy and substantial side-product formation. Through systematic investigation, we have developed …
The effectiveness of vedolizumab in advanced therapy-experienced ulcerative colitis patients: Real world data from the Inflammatory Bowel Disease of the Middle East (IBD-ME) Registry group
Publication Year: 2025 Source: Saudi J Gastroenterol PMID: 39291466
No Abstract
Monitoring the psychopathological profile of inflammatory bowel disease patients treated with biological agents: a pilot study
Publication Year: 2025 Source: Minerva Gastroenterol (Torino) PMID: 39292181 DOI: 10.23736/S2724-5985.24.03719-7
BACKGROUND: Biological agents were found to alter the psychopathological profile of a small subgroup of patients treated for a variety of conditions, including inflammatory bowel disease (IBD) and psychiatric disorders. The association between the administration of biological agents and psychopathology needs to be further investigated. METHODS: In this naturalistic prospective …
Intestinal epithelial expression of human TNF is sufficient to induce small bowel inflammation and sacroiliitis, mimicking human spondyloarthritis
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 39292604 DOI: 10.1093/rheumatology/keae507
OBJECTIVES: Gut and joint disease commonly co-occur in SpA. Up to 50% of patients with SpA show signs of subclinical gut inflammation, of which 10% develops IBD. However, the mechanisms underlying this gut-joint axis are still unclear. Here we investigated the hypothesis that restricted expression of a pro-inflammatory cytokine in …
Systematic review with meta-analysis of the effectiveness of subcutaneous biologics versus intravenous biologics in inflammatory bowel diseases
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39292973 DOI: 10.1097/MEG.0000000000002850
BACKGROUND: Biologic therapies are commonly used for inflammatory bowel disease (IBD) patients. Multiple biologic medicines can now be given both intravenously and subcutaneously. The different administration routes present provide different advantages regarding dose escalation, healthcare resource utilisation, pharmacokinetics, convenience and safety. Comparator effectiveness studies between intravenous and subcutaneous administration are …
The role of new inflammatory indices in the prediction of endoscopic and histological activity in inflammatory bowel disease patients
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39292974 DOI: 10.1097/MEG.0000000000002842
BACKGROUND AND AIM: Inflammatory indices are promising indicators that can be used to evaluate inflammation in inflammatory bowel diseases (IBDs). The present study aimed to investigate the test accuracy of several inflammatory indices to identify endoscopic, and histological activity in a cohort of IBD patients. STUDY: All IBD patients who …
Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis
Publication Year: 2025 Source: J Steroid Biochem Mol Biol PMID: 39293724 DOI: 10.1016/j.jsbmb.2024.106621
Inflammatory bowel disease (IBD) triggers chronic intestinal inflammation and is linked to primary sclerosing cholangitis (PSC). Cholesterol homeostasis, tightly regulated under normal conditions, becomes disrupted in both inflammation and chronic liver disease. We analyzed fecal and serum levels of cholesterol synthesis precursors, oxysterols, and phytosterols in 87 patients with IBD …
Opioid Use and Outcomes in Patients Hospitalized With Acute Severe Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39295282
BACKGROUND: Opioid use has not been shown to improve hospitalized inflammatory bowel disease patient pain scores and may prolong the length of stay (LOS). Additional clinical implications of opioid use, particularly high amounts, in the hospital setting have not yet been explored. We sought to determine how high opioid use …
Prolonged Time to Diagnosis of Crohn's Disease in Patients With Perianal Fistulas Negatively Affects Long-Term Outcomes
Publication Year: 2025 Source: J Crohns Colitis PMID: 39297524
BACKGROUND AND AIM: This study aims to evaluate the effect of time to Crohn's disease (CD) diagnosis on perianal fistula (PAF) outcomes in patients with a fistula as the first manifesting sign. METHODS: In this multicenter, retrospective study, CD patients with a PAF preceding CD diagnosis between November 2015 and …
Ileocolic resection with temporary ileostomy for Crohn's disease: does it affect long-term disease recurrence compared with primary anastomosis?
Publication Year: 2025 Source: ANZ J Surg PMID: 39297737
No Abstract
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide