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Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats
Publication Year: 2025 Source: Toxicol Mech Methods PMID: 40129370
Mycotoxins perturb the gut microbiota performance. Bioactive compounds have been recently used as a new food strategy to diminish mycotoxins bioaccessibility and prevent their toxic effects on human and animal health. Male and female Wistar rats were exposed orally to twelve different diets containing aflatoxin B1 (AFB1) and/or ochratoxin A …
Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases
Publication Year: 2025 Source: Front Cell Dev Biol PMID: 40129569
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), especially, exosomes are considered to have diverse therapeutic effects for various significant diseases. MSC-derived exosomes (MSCex) offer substantial advantages over MSCs due to their long-term preservation, stability, absence of nuclei and fewer adverse effects such as infusion toxicity, thereby paving the way towards regenerative …
Inflammatory Bowel Disease from the Perspective of Newer Innate Immune System Biomarkers
Publication Year: 2025 Source: Gastrointest Disord (Basel) PMID: 40129852 DOI: 10.3390/gidisord7010022
BACKGROUND: The perspective of inflammatory bowel disease (IBD) has changed radically since the first decade of the 21st century, and the formerly monolithic components of IBD, ulcerative colitis (UC), and Crohn's disease (CD) have undergone a fundamental convergence, with realization that there is likely an element of shared pathogenesis. The …
Thymoquinone Ameliorates Gut Epithelial Injury by Suppressing the JNK Signaling Pathway Based on Its Anti-Oxidant Property
Publication Year: 2025 Source: Food Sci Nutr PMID: 40129997
Ulcerative colitis is one of the most common sorts of inflammatory bowel disease. This study investigates the protective effects of thymoquinone against sodium dodecyl sulfate (SDS)-induced intestinal damage and elucidates the underlying mechanisms using the Drosophila melanogaster model of ulcerative colitis. We found that Drosophila fed thymoquinone from larval to …
Inulin Protects Caco-2 Cells Against Lipopolysaccharide-Induced Epithelial Barrier Dysfunction
Publication Year: 2025 Source: Food Sci Nutr PMID: 40129999 DOI: 10.1002/fsn3.70046
Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, triggers inflammatory responses in intestinal epithelial cells. This activation leads to the production of pro-inflammatory cytokines which disrupt cellular homeostasis. LPS also impairs the integrity of the intestinal epithelial barrier by downregulating tight junction proteins, resulting in increased intestinal …
Real-World Experience With Tofacitinib in Steroid-Dependent Patients With Moderate-to-Severe Ulcerative Colitis on Immunomodulators
Publication Year: 2025 Source: Cureus PMID: 40130137 DOI: 10.7759/cureus.79456
INTRODUCTION: Patients with moderate-to-severe ulcerative colitis (UC) who are steroid-dependent despite being on immunomodulators pose significant clinical challenges. Currently, biologics therapy is the only option apart from considering surgery. Tofacitinib is an oral Janus kinase inhibitor used as a second-line therapy for patients with UC following the failure of biologics …
Discovery of Potent and Balanced Dual RIPK2 and 3 Inhibitors as a New Strategy for the Treatment of Inflammatory Bowel Diseases
Publication Year: 2025 Source: J Med Chem PMID: 40131099 DOI: 10.1021/acs.jmedchem.4c03226
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) and RIPK3 have been demonstrated to be promising targets for treating multiple inflammatory diseases, including inflammatory bowel diseases (IBDs). Due to the complexity of IBD pathogenesis, on the basis of synergy strategies, we herein describe the discovery and optimization of a series of N,7-diaryl-quinazolin-4-amine …
SARS-CoV-2 infection in pregnant women and incidence of thromboembolic disease: an analysis of the Covid-19-Related Obstetric and Neonatal Outcome Study (CRONOS) in Germany
Publication Year: 2025 Source: Arch Gynecol Obstet PMID: 40131456
PURPOSE: The aim of the present study was to quantify the rate of thromboembolic events (TE) in pregnant women with SARS-CoV-2 infection and to characterize risk factors to provide a basis for individualized recommendation on prophylactic measures. METHODS: CRONOS is a multicenter, prospective observational study conducted in Germany and Austria …
The Evolving Guidelines on Fiber Intake for Patients with Inflammatory Bowel Disease; From Exclusion to Texture Modification
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40131665 DOI: 10.1007/s11894-025-00975-7
PURPOSE OF REVIEW: Fiber restriction has been a long-standing strategy for patients with inflammatory bowel disease (IBD), ostensibly to improve symptoms and reduce complications. Fiber though has a well-documented trophic effect on gut barrier defenses and the intestinal microbiome. This report discusses how texture modification may allow the safe and …
Treatment and survival of non-metastatic rectal cancer in patients with inflammatory bowel disease: nationwide cohort study
Publication Year: 2025 Source: BJS Open PMID: 40131793
BACKGROUND: Patients with inflammatory bowel disease have an increased risk of colorectal cancer. There is a scarcity of large studies with a focus on rectal cancer in patients with inflammatory bowel disease. This study aimed to compare survival in resected patients with rectal cancer with and without inflammatory bowel disease. …
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