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Comparative real-world effectiveness of ustekinumab versus anti-TNF in Crohn's disease: 12-month maintenance phase results from the prospective, observational RUN-CD study using propensity score adjustment
Publication Year: 2025 Source: J Crohns Colitis PMID: 40132057 DOI: 10.1093/ecco-jcc/jjaf051
BACKGROUND: The prospective RUN-CD registry investigates the effectiveness of ustekinumab (UST) and other biologics in Crohn's disease (CD) across Germany. Based on data from the registry, this study presents the maintenance phase results of a 12-month real-world-evidence (RWE) comparison of CD patients initiating new biologic therapies with UST or anti-TNF. …
Fabrication of multilayer heterogeneous cell assembly for pathophysiologically relevant 3Din-vitroIBD disease model for high throughput drug screening
Publication Year: 2025 Source: Biofabrication PMID: 40132231
Regarding the approval of novel pharmaceuticals, the most common reason for failure is inadequate oral drug bioavailability. Owing to the complex physiological milieu of the human intestine, which is characterized by its varied composition, various functions, and one-of-a-kind dynamic conditions, it is difficult to reproduce the organin vitro. Traditional monolayers …
The role of microbial succinate in the pathophysiology of inflammatory bowel disease: mechanisms and therapeutic potential
Publication Year: 2025 Source: Curr Opin Microbiol PMID: 40132355 DOI: 10.1016/j.mib.2025.102599
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition linked to gut microbiota dysbiosis and altered production of bacterial metabolites, including succinate, which is also a key intermediate in human mitochondrial energy metabolism in human cells. Succinate levels in the gut are influenced by microbial community dynamics and cross-feeding interactions, …
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Publication Year: 2025 Source: Cell PMID: 40132579
The gastrointestinal (GI) tract experiences a myriad of mechanical forces while orchestrating digestion and barrier immunity. A central conductor of these processes, the enteric nervous system (ENS), detects luminal pressure to regulate peristalsis independently of extrinsic input from the central and peripheral nervous systems. However, how the approximately 500 million …
Histologic alterations are common in Monogenic Disease patients with 'healthy' endoscopy: Results from a GIPAD-GIPPI multicenter study
Publication Year: 2025 Source: Hum Pathol PMID: 40132689 DOI: 10.1016/j.humpath.2025.105763
OBJECTIVE: Very early-onset inflammatory bowel disease (VEO-IBD) is a clinical umbrella term referring to IBD-like symptoms arising in children before 6 years of age, encompassing 'pure' IBD (Crohn's Colitis/Ulcerative Colitis)/non IBD colitis, and monogenic diseases (MDs), the latter often related to primary immunodeficiency disorders. A multidisciplinary approach is imperative for …
Clinical Practice Guidelines for post-ERCP pancreatitis 2023
Publication Year: 2025 Source: Dig Endosc PMID: 40132896
The Clinical Practice Guidelines for post-ERCP pancreatitis (PEP) 2023 provide updated recommendations for the prevention, diagnosis, and management of PEP. Endoscopic retrograde cholangiopancreatography (ERCP), a valuable procedure for diagnosing and treating pancreatobiliary diseases, can result in PEP as the most common adverse event. Since the first guidelines were published in …
Syphilis proctitis: an uncommon presentation of Treponema pallidum mimicking malignancy
Publication Year: 2025 Source: BMJ Case Rep PMID: 40132940
Syphilis proctitis is a rare manifestation of syphilis, a bacterial sexually transmitted infection caused by Treponema pallidum Syphilis proctitis can mimic other conditions including inflammatory bowel disease, lymphogranuloma venereum and anal or rectal cancer. We describe a case of a man in his 60s presenting with a variety of anorectal …
Impact of the loss of slc43a3 on 6-mercaptopurine absorption and tissue distribution in mice
Publication Year: 2025 Source: Drug Metab Dispos PMID: 40133022
6-Mercaptopurine (6-MP) is a nucleobase analog used in the therapy of acute lymphoblastic leukemia and inflammatory bowel disease. It is associated with numerous side effects including myelotoxicity, hepatotoxicity, and gastrointestinal complications, which can lead to patient adherence issues or discontinuation of treatment. This is further complicated by the wide variability …
Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota
Publication Year: 2025 Source: BMC Microbiol PMID: 40133818
Ulcerative colitis (UC) is an intestinal disease caused by many factors that seriously harms the health of humans and animals. Probiotics are currently widely used to treat intestinal inflammation; however, different strains are specific, and the functions and effects of different strains are still unclear. In this study, Lacticaseibacillus rhamnosus …
Clinical value of using double balloon enteroscopy combined with endoscopic ultrasound to evaluate Crohn's disease of the small bowel: a retrospective study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40133831
BACKGROUND: Diagnosing and assessing Crohn's disease, which involves only the small bowel, is challenging. This study investigated the clinical value of combining double balloon enteroscopy with endoscopic ultrasound to evaluate this disease. METHODS: This single-center retrospective study included patients with Crohn's disease of the small intestine between October 2022 and …
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