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The outcomes of robotic ileocolic resection in Crohn's disease compared with laparoscopic and open surgery: a meta-analysis and systematic review
Publication Year: 2025 Source: Tech Coloproctol PMID: 40138014
BACKGROUND: This is the first review providing insights into the outcomes of robotic ileocolic resection for Crohn's disease, potentially guiding improved surgical decisions and patient outcomes and comparing outcomes with laparoscopic and open approaches. METHODS: The review was registered prospectively with PROSPERO (CRD42024504839). A comprehensive search of MEDLINE, Embase, Scopus, …
Lipidated IL-22 Alone or Combined with Immunomodulatory Agents Improves Disease Endpoints and Promotes Mucosal Healing in a Mouse Model of Chronic Dextran Sodium Sulfate-Induced Colitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 40138118
BACKGROUND: IL-22 facilitates mucosal healing by directly inducing epithelial regeneration and barrier integrity, which is essential for achieving remission and thereby treating inflammatory bowel disease. AIMS: Here, we evaluated efficacy of a novel lipidated IL-22 alone and in combination with immunomodulatory agents in addressing chronic dextran sodium sulfate (DSS)-induced colitis …
BAICALIN INHIBITS CELL APOPTOSIS, INFLAMMATION, AND FERROPTOSIS IN ULCERATIVE COLITIS BY INFLUENCING SP1-MEDIATED TRANSCRIPTION OF SLC6A14
Publication Year: 2025 Source: Shock PMID: 40138728
Background: Baicalin is considered to be able to alleviate the progression of ulcerative colitis (UC), but the underlying molecular mechanism needs to be further elucidated. Methods: TNF-alpha-induced human normal colorectal mucosa cells (FHC) were used to mimic UC models in vitro , and trinitrobenzene sulfonic acid (TNBS)-injected rats were used …
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites
Publication Year: 2025 Source: Phytomedicine PMID: 40138774 DOI: 10.1016/j.phymed.2025.156671
BACKGROUND: Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is a chronic inflammatory disorder characterized by an unclear etiology, often linked to gut microbiota dysbiosis and immune dysregulation. Existing UC therapies are constrained by suboptimal efficacy and adverse effects, underscoring the necessity for novel therapeutic strategies. Diosmin (DIO), a naturally …
Effects of self-acupressure on quality of life and abdominal pain severity among patients with inflammatory bowel disease: A randomized sham-controlled trial
Publication Year: 2025 Source: J Ayurveda Integr Med PMID: 40139127 DOI: 10.1016/j.jaim.2024.101080
BACKGROUND: Acupressure is being used by patients to relieve functional gastrointestinal disorders. OBJECTIVE: The impact of acupressure on quality of life (QoL) and pain has been shown in patients with both acute and chronic conditions. However, its effects on individuals with inflammatory bowel disease (IBD) remain uncertain. This trial aims …
Enhancing Surgical Decision-Making in PSC-IBD: A Call for Comprehensive Long-Term Outcomes and Standardized Follow-Up Protocols
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40139179 DOI: 10.1093/ibd/izaf058
No Abstract
Switching biologic drug class after resection for Crohn's disease association with increased risk of reintervention
Publication Year: 2025 Source: J Gastrointest Surg PMID: 40139428
No Abstract
Polysaccharides from Cistanche deserticola mitigate inflammatory bowel disease via modulating intestinal microbiota and SRC/EGFR/PI3K/AKT signaling pathways
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40139591 DOI: 10.1016/j.ijbiomac.2025.142452
Polysaccharides of Cistanche deserticola Ma (CDPS), with high safety and low toxicity have been reported to possess anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anti-osteoporosis, antidepressant, intestinal flora regulatory and hepatoprotective properties. Nevertheless, the effects of CDPS on inflammatory bowel disease (IBD) and its underlying mechanisms have never been reported. To estimate its …
Diagnostic accuracy in the Swedish national patient register: a review including diagnoses in the outpatient register
Publication Year: 2025 Source: Eur J Epidemiol PMID: 40140143
BACKGROUND: The Swedish National Patient Register (NPR) is an important source of data for epidemiological research. A review in 2010 described the validity of recorded diagnoses for inpatient care, but did not include specialised outpatient care. METHOD: Using systematic searches of medical literature databases (Embase, Medline), and reports from members …
Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease
Publication Year: 2025 Source: BMC Med PMID: 40140901 DOI: 10.1186/s12916-025-04016-y
Inflammatory bowel disease (IBD) refers to chronic, recurrent inflammatory intestinal disorders, primarily including Crohn's disease (CD) and Ulcerative colitis (UC). Numerous studies have elucidated the importance of the gut microbiome in IBD. Recently, numerous studies have focused on the gut virome, an intriguing and enigmatic aspect of the gut microbiome. …
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