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Understanding Role of Nutrition in Inflammatory Bowel Disease: A Comprehensive Review With Incorporation of AGA Update
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40134326 DOI: 10.1111/jgh.16939
This comprehensive review delves into the evolving landscape of nutrition's role in Inflammatory Bowel Disease (IBD), while incorporating transformative insights from the recently published American Gastroenterology Association (AGA) clinical practice update (CPU) on diet in IBD. Recent years have witnessed a paradigm shift, recognizing diet not only as an influencer …
Engineered Turmeric-Derived Nanovesicles for Ulcerative Colitis Therapy by Attenuating Oxidative Stress and Alleviating Inflammation
Publication Year: 2025 Source: Mol Pharm PMID: 40134348
Inflammation and oxidative stress are important features of traumatic ulcerative colitis (UC). Turmeric has been used as a dietary and functional ingredient for its potent anti-inflammatory effects in UC therapy. However, its practical effectiveness is hindered by limited reactive oxygen species (ROS) elimination properties. To address this, we constructed a …
Bariatric Surgery Is Associated With Reduced Incidence of Mild Cognitive Impairment and Alzheimer Disease and Related Dementias: A Retrospective Cohort Study
Publication Year: 2025 Source: Ann Surg Open PMID: 40134493
OBJECTIVE: To evaluate the association of bariatric surgery with reduced incidence and delayed development of mild cognitive impairment (MCI) and Alzheimer disease and related dementias (ADRD) in patients with obesity. BACKGROUND: This retrospective longitudinal study utilized Electronic Health Records from Vanderbilt University Medical Center, covering 5303 patients who underwent bariatric …
Artificial intelligence-driven strategies for managing renal and urinary complications in inflammatory bowel disease
Publication Year: 2025 Source: World J Nephrol PMID: 40134643 DOI: 10.5527/wjn.v14.i1.100825
In this editorial, we discuss the article by Singh et al published in World Journal of Nephrology, stating the need for timely adjustments in inflammatory bowel disease (IBD) patients' long-term management plans. IBD is chronic and lifelong, with recurrence and remission cycles, including ulcerative colitis and Crohn's disease. It's exact …
Editorial: Understanding molecular mechanisms to facilitate the development of biomarkers for therapeutic intervention in gastrointestinal diseases and sepsis
Publication Year: 2025 Source: Front Genet PMID: 40134719
No Abstract
Enteroscopic Balloon Dilation in Small Bowel Stricturing Crohn's Disease: Long-Term Outcomes and Risk Factors for Surgery in a Single-Center Prospective Observational Study
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40136032
BACKGROUND AND AIMS: The long-term outcomes of enteroscopic balloon dilation for small bowel strictures in patients with Crohn's disease are not well understood. Although Crohn's strictures can be classified into web-like, ulcerated, and spindle-shaped strictures based on endoscopic findings, the outcomes of enteroscopic balloon dilation according to the shape of …
Oral pH- and inflammation-targeted delivery system with biodegradable multi-layer core-shell nanocapsules for the treatment of ulcerative colitis
Publication Year: 2025 Source: Nanoscale PMID: 40136045
Most biologics require administration via parenteral routes; however, the pain and local allergic reaction brought about by injection usually lead to poor compliance, especially for chronic patients. Meanwhile, the oral delivery of biologics faces great challenges due to the complex physiological environment of the gastrointestinal tract. Herein, we developed a …
A Pilot Study on the Role of TRAFs in the Development of SARS-CoV-2 Infection Before and After Immunization with AstraZeneca Chadox1 in Mice
Publication Year: 2025 Source: Curr Issues Mol Biol PMID: 40136419
The TRAF family of molecules are intracellular signaling adaptors that regulate various signaling pathways. These pathways are not only mediated by the TNFR superfamily and the Toll-like receptor/IL-1 receptor superfamily but also by unconventional cytokine receptors like IL-6 and IL-17 receptors. Overactive immune responses caused by TRAF signaling following the …
Pyoderma Gangrenosum in a Patient with Crohn's Disease Treated with Adalimumab: A Case-Based Review and Systematic Review of the Current Literature
Publication Year: 2025 Source: Clin Pract PMID: 40136593 DOI: 10.3390/clinpract15030057
Background: Pyoderma gangrenosum (PG) is a rare inflammatory cutaneous disorder that frequently occurs in association with systemic diseases such as inflammatory bowel disease (IBD). This case report describes a 23-year-old female with Crohn's disease (CD) who developed PG and was successfully treated with adalimumab. The objective of this study is …
Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies
Publication Year: 2025 Source: J Pers Med PMID: 40137428 DOI: 10.3390/jpm15030112
The appendix, an integral part of the large intestine, may serve two purposes. First of all, it is a concentration of lymphoid tissue that resembles Peyer's patches. It is also the main location in the body for the creation of immunoglobulin A (IgA), which is essential for controlling intestinal flora's …
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