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A British Society of Gastrointestinal and Abdominal Radiology multi-centre audit of imaging investigations in inflammatory bowel disease
Publication Year: 2025 Source: Br J Radiol PMID: 40065511 DOI: 10.1093/bjr/tqaf050
OBJECTIVES: To evaluate current UK practice for inflammatory bowel disease (IBD) imaging against recommendations from published international literature. METHODS: A retrospective multi-centre audit was undertaken evaluating imaging modalities, protocols, and pathways used to investigate IBD both in outpatient and inpatient settings during January-December 2022. Reporting practices and training provisions were …
Japanese Phase 1 Study for Global Development of Anti-TL1A Antibody PF-06480605: A Randomized, Placebo-Controlled, Single-Ascending Dose Study
Publication Year: 2025 Source: Clin Transl Sci PMID: 40065559
PF-06480605, a fully human IgG1 monoclonal antibody targeting tumor necrosis factor alpha-like ligand 1A (TL1A), has demonstrated acceptable safety and the potential as an effective treatment for inflammatory bowel disease in phase 1/2a studies. To facilitate future clinical development in Japan and China, a Japan local phase 1 study was …
Substantial Reduction of Systemic Corticosteroid Use After Primary Ileocaecal Resection in Swedish Patients With Crohn's Disease: A Population-Based Cohort Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40065562
BACKGROUND: The corticosteroid-sparing effects of ileocaecal resection have not been thoroughly investigated in a population-based cohort. AIM: To investigate systemic corticosteroid use before and after primary ileocaecal resection in patients with Crohn's disease. METHODS: Through nationwide registries, we identified 1565 patients with Crohn's disease undergoing primary ileocaecal resection in Sweden …
Comparative Effectiveness of Dual Biologic Therapy and Biologic Small-Molecule Therapy for Refractory Inflammatory Bowel Disease: A Retrospective Single-Center Study
Publication Year: 2025 Source: Clin Transl Sci PMID: 40065597 DOI: 10.1111/cts.70198
Patients with refractory inflammatory bowel disease (IBD) face difficulty in the treatment strategy. Combined advanced targeted therapies may obtain higher therapeutic efficacy. However, few studies compare the efficacy and safety of dual biologic therapy (DBT) with biologic small-molecule therapy (BMT) for refractory IBD. We aimed to compare the effectiveness of …
Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40065724
BACKGROUND AND AIMS: Bacteroides fragilis toxin (BFT), produced by enterotoxigenic B. fragilis (ETBF), is crucial for ETBF-induced colitis. This study aims to investigate the impact of BFT-host interactions on N6-methyladenosine (m6A) modification of host mRNA and its underlying mechanisms. METHODS: Single-cell sequencing was employed to identify the cell types involved …
Saccharomyces boulardii Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis
Publication Year: 2025 Source: J Inflamm Res PMID: 40065908 DOI: 10.2147/JIR.S504957
BACKGROUND: Ulcerative colitis (UC), a typical inflammatory bowel disease (IBD), is pathologically defined by mucosal inflammation confined to the colonic mucosa. Saccharomyces boulardii (Sb), a commonly utilized probiotic yeast for managing digestive disorders like UC, has not been thoroughly investigated regarding its precise mechanisms for alleviating colitis. Increasing evidence indicates …
Etiologies of exocrine pancreatic insufficiency
Publication Year: 2025 Source: Gastroenterol Rep (Oxf) PMID: 40066317
Exocrine pancreatic insufficiency (EPI) is a major cause of maldigestion and malnutrition, resulting from primary pancreatic diseases or other conditions. As the prevalence of EPI continues to rise, accurate identification of its etiology has become critical for the diagnosis and treatment of pancreatic secretory insufficiency. EPI can result from both …
The role of m(6)A modification during macrophage metabolic reprogramming in human diseases and animal models
Publication Year: 2025 Source: Front Immunol PMID: 40066451 DOI: 10.3389/fimmu.2025.1521196
Macrophage metabolic reprogramming refers to the process by which macrophages adjust their physiological pathways to meet survival and functional demands in different immune microenvironments. This involves a range of metabolic pathways, including glycolysis, the tricarboxylic acid cycle, oxidative phosphorylation, fatty acid oxidation, and cholesterol transport. By modulating the expression and …
A Comprehensive Review of Traditional Chinese Medicine in the Management of Ulcerative Colitis
Publication Year: 2025 Source: Am J Chin Med PMID: 40066486
Ulcerative colitis (UC) is a chronic, nonspecific inflammatory disorder characterized by symptoms such as abdominal pain, diarrhea, hematochezia, and urgency during defecation. While the primary site of involvement is the colon, UC can extend to encompass the entire rectum and colon. The causes and development mechanisms of UC are still …
Definitions, diagnosis, and management of postoperative recurrence in Crohn's disease patients with permanent ileostomy-a systematic review and meta-analysis
Publication Year: 2025 Source: J Crohns Colitis PMID: 40066499
BACKGROUND AND AIMS: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy. METHODS: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024. Randomized controlled …
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