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Discrepancies in perceptions of well-being: comparing parental and pediatric PROMIS-patient-reported outcomes in Crohn's disease
Publication Year: 2025 Source: J Patient Rep Outcomes PMID: 40155529
BACKGROUND: This study aims to evaluate and compare the perspectives of pediatric Crohn's disease (CD) patients and their parents/caregivers concerning global physical, emotional, and social health as well as health-related quality of life (HRQQL), using both the Patient-Reported Outcomes Measurement Information System (PROMIS) and the IMPACT III questionnaire. METHODS: In …
Early diagnosis of Crohn's disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index
Publication Year: 2025 Source: Tech Coloproctol PMID: 40155532 DOI: 10.1007/s10151-024-03106-y
BACKGROUND: Delay in diagnosing Crohn's disease (CD) in patients presenting with perianal abscess (PAA) and/or fistula (PAF) is common. The aim of this study was to identify red flags suggestive of CD. METHODS: A systematic literature review was conducted to identify symptoms associated with CD in patients presenting with PAA/PAF. …
Analysis of the molecular mechanisms of ulcerative colitis and atherosclerosis by microarray data
Publication Year: 2025 Source: Sci Rep PMID: 40155679
Adults can develop ulcerative colitis (UC), a chronic inflammatory illness of the colon, while atherosclerosis (AA) is a chronic inflammatory disease of the blood vessels caused by a range of risk factors. Prior research has demonstrated that UC increases the risk of AA, although the underlying pathological mechanisms are not …
Gastrointestinal traits, common inflammatory disorders, gallstones, and biliary tract cancer: A network Mendelian randomization study
Publication Year: 2025 Source: J Adv Res PMID: 40064441
INTRODUCTION: Observational studies have shown that gallstone disease (GSD), cholecystitis, cholangitis, polyp of gallbladder, viral hepatitis, pancreatitis and gastrointestinal (GI) traits such as H. pylori infection, inflammatory bowel disease, and digestive ulcer are associated with the risk of biliary tract cancer (BTC). However, no study has explored their causal associations. …
Relating the molecular phenotype of ulcerative colitis to the clinical course
Publication Year: 2025 Source: Sci Rep PMID: 40064933
The expanding portfolio of targeted therapies for ulcerative colitis (UC) suggests that a more precise approach to defining disease activity will aid clinical decision-making. This prospective study used genome-wide microarrays to characterize gene expression in biopsies from the most inflamed colon segments from patients with UC and analyzed associations between …
Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon
Publication Year: 2025 Source: EMBO Mol Med PMID: 40065134
Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7alpha-dehydroxylated bile acids are notably diminished in inflammatory bowel disease patients. Herein, we investigated whether restoration of 7alpha-dehydroxylated bile acids levels by Clostridium scindens, a human-derived 7alpha-dehydroxylating bacterium, can …
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Publication Year: 2025 Source: Nat Rev Microbiol PMID: 40065181 DOI: 10.1038/s41579-025-01163-0
Perturbations in the intestinal microbiome are strongly linked to the pathogenesis of inflammatory bowel disease (IBD). Bacteria, fungi and viruses all make up part of a complex multi-kingdom community colonizing the gastrointestinal tract, often referred to as the gut microbiome. They can exert various effects on the host that can …
Using gut microbiota and non-targeted metabolomics techniques to study the effect of xylitol on alleviating DSS-induced inflammatory bowel disease in mice
Publication Year: 2025 Source: BMC Immunol PMID: 40065221 DOI: 10.1186/s12865-025-00700-z
BACKGROUND: Inflammatory bowel disease (IBD) has become a global healthcare issue, with its incidence continuing to rise, but currently there is no complete cure. Xylitol is a widely used sweetener in various foods and beverages, but there is limited research on the effects of xylitol on IBD symptoms. AIM: Study …
Ginseng exosomes modulate M1/M2 polarisation by activating autophagy and target IKK/IкB/NF-кB to alleviate inflammatory bowel disease
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40065319
BACKGROUND: Exosomes are involved in intercellular communication and regulation of the inflammatory microenvironment. In a previous study, we demonstrated that fresh ginseng exosomes (GEs) alleviated inflammatory bowel disease. However, the precise mechanism by which GEs activate the immune system and subsequently inhibit the formation of intestinal inflammatory microenvironment remains unknown. …
Environmental risk factors of inflammatory bowel disease: toward a strategy of preventative health
Publication Year: 2025 Source: J Crohns Colitis PMID: 40065502 DOI: 10.1093/ecco-jcc/jjaf042
The pathogenesis of inflammatory bowel disease (IBD) involves a complex interplay between genetic, environmental, and microbial factors. Many of these environmental determinants are modifiable, offering opportunities to prevent disease or delay its onset. Advances in the study of preclinical IBD cohorts offer the potential to identify biomarkers that predict individuals …
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