Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Comparative efficacy and safety of vedolizumab and antitumor necrosis factor alfa in patients with inflammatory bowel diseases: A meta‑analysis
Publication Year: 2025 Source: Acta Pharm PMID: 40068941 DOI: 10.2478/acph-2025-0004
This meta-analysis directly compares the efficacy and safety of vedolizumab and tumor necrosis factor-alpha (TNF-alpha) inhibitors for patients with inflammatory bowel disease (IBD), contrary to the previous one which provided an indirect comparison. In this meta-analysis, only the studies that directly compared two treatments (vedolizumab and TNF-alpha inhibitors) to each …
Interpretation of de novo mutations (DNM) and genetic counseling for sporadic hearing loss based on family trio-based sequencing
Publication Year: 2025 Source: Yi Chuan PMID: 40068948 DOI: 10.16288/j.yczz.24-228
De novo mutations (DNMs) are significant genetic factors contributing to sporadic hearing loss (HL) and complex HL syndromes. To analyze the genetic counseling characteristics and interpretation of pathogenic DNMs for sporadic HL, we retrospectively analyze the clinical information of probands and their parents from 410 sporadic HL core pedigrees enrolled …
A two-transcript classifier model for assessing disease activity in patients with ulcerative colitis: A discovery and validation study
Publication Year: 2025 Source: Dig Liver Dis PMID: 40069026
AIMS: We aimed to develop and validate classifier models to assess disease activity in UC patients by evaluating potential classifier genes expression levels. METHODS: The study comprised UC and healthy control participants undergoing colonoscopy. We screened candidate genes (TGF-beta1, CEACAM1 and CD177) using Differentially Expressed Genes. We compared candidate genes …
A comprehensive dataset of magnetic resonance enterography images with intestinal segment annotations
Publication Year: 2025 Source: Sci Data PMID: 40069172 DOI: 10.1038/s41597-025-04760-z
Inflammatory bowel disease (IBD) is a recurrent bowel disease that usually requires magnetic resonance enterography (MRE) for diagnosis and monitoring. However, recognition of bowel segments from MRE images by a radiologist is challenging and time-consuming. Deep learning-based medical image segmentation has shown the potential to reduce manual effort and provide …
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease
Publication Year: 2025 Source: Acta Pharmacol Sin PMID: 40069490 DOI: 10.1038/s41401-025-01525-7
Current treatments of inflammatory bowel disease (IBD) largely depend on anti-inflammatory and immunosuppressive strategies with unacceptable efficacy and adverse events. Resolution or repair agents to treat IBD are not available but potential targets like formyl peptide receptor 2 (FPR2/ALX) may fill the gap. In this study we evaluated the therapeutic …
Tolerability and Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40069510 DOI: 10.1007/s10620-025-08964-6
PURPOSE: Glucagon-like peptide 1 receptor agonists (GLP-1 RA) have transformed obesity management, but their safety and efficacy in patients with inflammatory bowel disease (IBD) warrants further evaluation. METHODS: This retrospective cohort study included adults with obesity and a diagnosis of IBD who were treated with GLP-1 RA within a large …
Transformative Results in Giant Pyoderma Gangrenosum with Dexamethasone-cyclophosphamide Pulse
Publication Year: 2025 Source: Ann Afr Med PMID: 40069562
Pyoderma gangrenosum (PG) is a cutaneous ulcerative condition that can present in various forms, including ulcerative, bullous, pustular, vegetative, and peristomal. It often occurs and recurs in areas subjected to trauma due to the pathergy phenomenon, where irritation or injury triggers flare-ups. The condition typically begins as a painful erythematous …
Study on the characteristics of genetic diversity and population structure of a rare and endangered species of Rhododendron nymphaeoides (Ericaceae) based on microsatellite markers
Publication Year: 2025 Source: BMC Plant Biol PMID: 40069601 DOI: 10.1186/s12870-025-06362-8
BACKGROUND: Rhododendron nymphaeoides is explicitly listed as an endangered species in the "the International Union for Conservation of Nature's Red List (IUCN)", "The Red List of Rhododendrons", "Red List of China's Higher Plants" and "Threatened Species List of China's Higher Plants". It is also listed as a provincial-level key protected …
Caution in Handling Switchers in Pharmacoepidemiologic Studies Estimating Treatment Effects: The Example of Dipeptidyl Peptidase-4 Inhibitors and Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Epidemiol PMID: 40069957 DOI: 10.1093/aje/kwaf044
Real-world evidence assessing dipeptidyl peptidase-4 inhibitors (DPP4i)'s risk of inflammatory bowel disease (IBD) is conflicting. One study modelling DPP4i as a time varying exposure (TVE) observed a harmful effect in a UK population, while an active-comparator new-user (ACNU) study observed a null effect in a US population. To assess the …
Clinical Analysis and Network Pharmacology in Revealing the Mechanism of Daifu Decoction on the Relapse of UC
Publication Year: 2025 Source: Drug Des Devel Ther PMID: 40070532
BACKGROUND: Daifu Decoction (DFD), a patented herbal prescription used to prevent and treat ulcerative colitis (UC). This study aimed to reveal the effect of DFD on the relapse of UC and its mechanism via integrated retrospective clinical analysis, network pharmacology and in vivo and in vitro experimental validation. METHODS: First, …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide