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Combining mechanistic modeling with machine learning as a strategy to predict inflammatory bowel disease clinical scores
Publication Year: 2025 Source: Front Pharmacol PMID: 40070575 DOI: 10.3389/fphar.2025.1479666
Disease activity scores are efficacy endpoints in clinical trials of inflammatory bowel disease (IBD) therapies. Crohn's disease activity index (CDAI), Mayo endoscopic score (MES) and Mayo score are frequently used in clinical trials. They rely on either the physician's observation of the inflammatory state of the patient's gastrointestinal tissue alone …
From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases - Opportunity or Challenge?
Publication Year: 2025 Source: J Inflamm Res PMID: 40070928
Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation of Gasdermin proteins, which form membrane pores, leading to rapid cell rupture and the release of inflammatory molecules. Unlike other types of cell death, pyroptosis has distinct activation mechanisms and plays a complex …
A new autochthonous case of amebiasis in Italy in a patient without risk factors: an alert for clinicians and laboratorians
Publication Year: 2025 Source: Infez Med PMID: 40071264
We describe a rare case of intestinal amebiasis of unknown source, in an immunocompetent patient with no risk factors. The detection of an autochthonous Entamoeba histolytica strain causing ulcerative colitis (UC) in a healthy individual was unexpected, but it was the second time it had occurred in Italy in a …
IL-23p19 Antagonists vs Ustekinumab for Treatment of Crohn's Disease: A Meta-Analysis of Randomized Controlled Trials
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40071763
INTRODUCTION: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing interleukin (IL)-23p19 antagonists with ustekinumab, stratified by prior biologic exposure, in patients with moderate-to-severe Crohn's disease (CD). METHODS: Through a systematic review through August 17, 2024, we identified phase 2 and 3 RCTs comparing IL-23p19 antagonists …
Long-Term Safety of Mirikizumab in Patients With Moderately to Severely Active Ulcerative Colitis: An Integrated 2-Year Safety Analysis
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40071779
INTRODUCTION: Ulcerative colitis (UC) is a chronic immune-mediated disease requiring ongoing treatment to maintain remission. This report presents the 2-year safety outcomes of mirikizumab, a humanized immunoglobulin G4 anti-interleukin-23p19 monoclonal antibody, in moderately to severely active UC from phase 3 studies LUCENT-1 (NCT03518086), LUCENT-2 (NCT03524092), and LUCENT-3 (NCT03519945). METHODS: Patients …
A Biomimetic Sweeping Microrobot for Active Therapy of Ulcerative Colitis
Publication Year: 2025 Source: Adv Mater PMID: 40072036
Overproduction of pathogenic cell-free DNA (cfDNA) and reactive oxygen species (ROS) plays crucial roles in the onset and perpetuation of ulcerative colitis (UC). Inspired by sweeping robots, a magnesium@polylactic acid-glycolic acid copolymer@polyethylenimine (Mg@PLGA@PEI) microswimmer capable of cleaning off deleterious disease triggers along its path of progress is designed. Mg@PLGA@PEI is …
Biological Effects of Micro-/Nano-Plastics in Macrophages
Publication Year: 2025 Source: Nanomaterials (Basel) PMID: 40072197 DOI: 10.3390/nano15050394
The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence of micro- (MPs) and nanosized (NPs) plastic particles. MPs and NPs are thus widely present in water and air and inevitably enter the food chain, with inhalation and ingestion as the main exposure …
Higher Life's Essential 8 score is associated with reduced risk of related surgery and all-cause mortality among 3232 individuals with inflammatory bowel disease in a longitudinal cohort study
Publication Year: 2025 Source: Int J Surg PMID: 40072359 DOI: 10.1097/JS9.0000000000002335
BACKGROUND: Previous studies indicated discrete lifestyle health metrics that benefit cardiovascular health are associated with better prognosis in inflammatory bowel disease (IBD), while evidence regarding the comprehensive impact of cardiovascular health remains limited. This study aimed to investigate the association between the overall cardiovascular health indicator, Life's Essential 8 (LE8), …
Dietary risk factors in Crohn's disease and ulcerative colitis: a cohort study with paired healthy relatives as controls
Publication Year: 2025 Source: Eur J Nutr PMID: 40072660 DOI: 10.1007/s00394-025-03598-w
PURPOSE: Conflicting results have been reported on dietary factors in inflammatory bowel diseases (IBDs). Here, we compared the dietary intakes of IBD patients with those of paired healthy relatives (HRs), aiming to minimize the impact of genetic and environmental confounders. METHODS: Patients with Crohn's disease (CD, N = 45) and …
Concise Commentary: Do Population Migrations Affect the Incidence, Severity, and Outcomes of Inflammatory Bowel Disease?
Publication Year: 2025 Source: Dig Dis Sci PMID: 40072767
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