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GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism
Publication Year: 2025 Source: Gut PMID: 40074327 DOI: 10.1136/gutjnl-2024-334010
BACKGROUND: GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesis remains unclear. OBJECTIVE: We aimed to investigate the role of GPR171 in modulating CD4(+) T cell effector functions in IBD and evaluate its therapeutic potential. DESIGN: We analysed GPR171 expression …
Author's reply: "Navigating anti-TNF therapy risks: Real-world insights on pregnancy, breastfeeding, and vaccines in IBD patients"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40074571 DOI: 10.1016/j.dld.2025.02.006
No Abstract
Endoscopic healing in IBD: Still the target to achieve?
Publication Year: 2025 Source: Dig Liver Dis PMID: 40074573 DOI: 10.1016/j.dld.2025.02.009
Mucosal healing is the mainstream goal of modern treat-to-target strategy as it is associated with a significantly more favorable disease course in IBD patients with either ulcerative colitis or Crohn's disease. Recent advances in endoscopic imaging technologies have overcome the traditional concept of mucosal healing assessed with conventional white light …
Fecal microbiota transplantation for vancomycin-resistant Clostridium innocuum infection in inflammatory bowel disease: A pilot study evaluating safety and clinical and microbiota outcome
Publication Year: 2025 Source: J Microbiol Immunol Infect PMID: 40074633 DOI: 10.1016/j.jmii.2025.03.004
BACKGROUND: Clostridium innocuum is a vancomycin-resistant pathobiome associated with poor clinical outcomes in inflammatory bowel disease (IBD). In ulcerative colitis (UC), it correlates with reduced remission rates, while in Crohn's disease (CD), it is linked to creeping fat formation and intestinal strictures. Notably, some patients experience refractory or recurrent C. …
Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway
Publication Year: 2025 Source: Commun Biol PMID: 40074811
Necrotizing enterocolitis (NEC) is a devastating inflammatory bowel necrosis of preterm infants with limited therapeutic approaches. Mounting evidence supports the role of Piezo1, namely, a widely distributed mechanosensor in intestinal epithelial cells (IECs), in intestinal inflammation but its underlying mechanism in the development of NEC remains unexplored. In this study, …
Robotic proctocolectomy with ileal pouch-anal anastomosis: a hybrid approach
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40074919
PURPOSE: Proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the definitive surgical treatment for patients with ulcerative colitis or familial adenomatous polyposis. While laparoscopic surgery has been widely adopted, robotic surgery has emerged as a promising alternative, particularly for complex pelvic dissection. However, the robotic learning curve presents significant challenges. This …
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation
Publication Year: 2025 Source: Nat Immunol PMID: 40074948
The tuft cell-group 2 innate lymphoid cell (ILC2) circuit orchestrates rapid type 2 responses upon detecting microbially derived succinate and luminal helminths. Our findings delineate key mechanistic steps involving IP3R2 engagement and Ca(2+) flux, governing interleukin-25 (IL-25) production by tuft cells triggered by succinate detection. While IL-17RB has a pivotal …
Characterization of post-inflammatory irritable bowel syndrome animal model following acute colitis recovery
Publication Year: 2025 Source: Sci Rep PMID: 40075091
Irritable bowel syndrome (IBS) is a prevalent disorder with an unclear pathophysiology. This study aimed to investigate the features of dextran sulfate sodium (DSS)-induced low-grade inflammation using murine models of acute severe colitis (acute model) and chronic mild repeated colitis (chronic model), with potential implications for IBS research. The acute …
Cancer Risk in IBD Patients Treated with JAK Inhibitors: Reassuring Evidence from Trials and Real-World Data
Publication Year: 2025 Source: Cancers (Basel) PMID: 40075582 DOI: 10.3390/cancers17050735
The advent of Janus kinase (JAK) inhibitors, including tofacitinib, filgotinib, and upadacitinib, has significantly widened the therapeutic options for patients with inflammatory bowel disease (IBD). These agents offer the advantage of oral administration and have demonstrated efficacy in inducing and maintaining remission. However, concerns regarding their safety have emerged, particularly …
Colitis-Associated Dysplasia in Inflammatory Bowel Disease: Features and Endoscopic Management
Publication Year: 2025 Source: Cancers (Basel) PMID: 40075631 DOI: 10.3390/cancers17050784
Patients with long-standing inflammatory bowel disease (IBD) involving the colon are at higher risk of developing colorectal dysplastic or neoplastic lesions. While from sporadic colorectal cancer follows an "adenoma-carcinoma" sequence, IBD colitis-associated carcinogenesis is mainly related to an "inflammation-dysplasia-carcinoma" sequence. Currently, specific endoscopic surveillance strategies involving dye spray and virtual …
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