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The Impact of Genetic Variation on Drug Response in Adult IBD: A Systematic Review
Publication Year: 2025 Source: JGH Open PMID: 40697426
No Abstract
Insurance Denial of Biologic Therapy is Associated With Reduced Remission Rates in Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40692821
BACKGROUND AND AIMS: Biologic therapy is indicated for patients with moderate to severe inflammatory bowel disease (IBD) and delays in access to these medications have been associated with higher health-care utilization. We examined whether patients who experienced insurance denials of biologics had worse outcomes, as indicated by disease activity and …
Care of Patients With Inflammatory Bowel Disease With Inadequate Response or Intolerance to Upadacitinib
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40692823
No Abstract
Concurrent multi-systemic eosinophilic epitheliotropic disease and choledocholithiasis in a 15-year-old mixed-breed mare
Publication Year: 2025 Source: Vet Res Forum PMID: 40693031
A mixed-breed 15-year-old mare was euthanized for recurrent colic, severe weight loss, pastern ulcerative dermatitis, and coronitis without response to non-surgical medical procedures. The liver was congested with firm consistency at necropsy, and there were multi-focal white spots on Glisson's capsule. Hemorrhage, ulcer, severe folding, and hypertrophy were seen in …
Commentary: Anti-TNFα in inflammatory bowel disease: from originators to biosimilars
Publication Year: 2025 Source: Front Pharmacol PMID: 40693265
No Abstract
OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 40694333
8-oxo-7,8-dihydroguanine (8-oxoG), the most frequent form of oxidative-DNA-base lesion caused by ROS, is recognized and repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) through base excision repair (BER) pathway. Beyond its role in DNA repair, OGG1 has been shown to promote transcriptional activation of proinflammatory mediators and contribute to both acute …
Paederia scandens-derived exosome-like nanoparticles as a delivery system for andrographolide to treat ulcerative colitis
Publication Year: 2025 Source: Cell Signal PMID: 40695370
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing colon inflammation. Side effects and drug resistance limit current therapies. Andrographolide (AG), an NF-kappaB pathway inhibitor, shows promise in UC treatment but suffers from poor oral bioavailability. In this study, Paederia scandens-derived exosome-like nanoparticles (P-ELNs) were used as …
Gut microbiota-host post-translational modification axis in immunometabolic diseases
Publication Year: 2025 Source: Trends Immunol PMID: 40695628
Communication between the gut microbiota and host post-translational modifications (PTMs) has been extensively characterized, and recent evidence delineates a functionally integrated gut microbiota-host PTM axis. This axis is not only essential for maintaining metabolism homeostasis but also plays diverse roles in regulating disease pathogenesis. In this review we discuss the …
Clinical Application of Chinese Herbal Medicine in Small Animal Practice
Publication Year: 2025 Source: Vet Clin North Am Small Anim Pract PMID: 40695659
Rooted in over 4000 years of empirical knowledge and systematic documentation, Chinese herbal medicine (CHM) has evolved into a sophisticated therapeutic modality for managing various medical conditions. This article explores the clinical application of CHM in small animal practice, emphasizing its unique diagnostic framework of pattern diagnosis. Key examples of …
Effectiveness of combination the photobiomodulation therapy and triamcinolone acetonide on managing oral major aphthous ulcer in Crohn's disease: A case report
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40696693
RATIONALE: Inflammatory bowel diseases like Crohn's disease can manifest with oral ulcers that negatively impact quality of life. Managing these stubborn symptomatic lesions requires an integrated medical and dental approach. PATIENT CONCERNS: A 23-year-old male was diagnosed with Crohn's disease 3 years ago. He was referred to the oral medicine …
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