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An Olsalazine-Loaded Hollow Mesoporous Prussian Blue/Polydopamine Nanozyme Alleviates Anxiety/Depression-like Behavior and Enhances Brain Neural Activity in Colitis Mice
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40699132
Individuals diagnosed with inflammatory bowel disease (IBD) exhibit a markedly elevated prevalence of psychiatric disorders, particularly anxiety and depression. However, the underlying mechanisms contributing to the development of these psychiatric conditions in IBD patients remain poorly understood, and no effective therapeutic strategy has been definitively established. Recent advancements in nanotechnology-based …
Clinical and environmental impact of intestinal ultrasound for inflammatory bowel disease: a tertiary centre experience in Southeast Asia
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40698902
OBJECTIVES: Inflammatory bowel disease (IBD) is a chronic relapsing disease primarily affecting the gastrointestinal tract, comprising mainly of ulcerative colitis and Crohn's disease. Intestinal ultrasound (IUS) evaluates transmural healing, which is associated with better clinical outcomes. The aims of this study were to determine the influence of IUS on clinical …
Assessment of oxidative stress parameters for evaluation of disease activity in patients with ulcerative colitis
Publication Year: 2025 Source: J Physiol Pharmacol PMID: 40698791
Neutrophil infiltration of the intestinal mucosa correlates closely with disease activity in ulcerative colitis (UC). This study aimed to investigate the contribution of reactive oxygen species (ROS) to disease severity in UC. Sixty-four subjects were enrolled, including 35 patients with active UC (18 males, 17 females; mean age: 38.1+/-13.6 years) …
Improvement in Functional Outcomes Following Ileal Pouch-Anal Anastomosis: Results from the United States Ileal Pouch-Anal Anastomosis Study
Publication Year: 2025 Source: Dis Colon Rectum PMID: 40698674
BACKGROUND: Ileal pouch-anal anastomosis is the standard procedure for patients with ulcerative colitis or unclassified inflammatory bowel disease seeking intestinal continuity post-proctocolectomy. Previous studies on function are limited by retrospective design, single-center scope, and insufficient functional domain data. OBJECTIVE: To provide prospective, multicenter data on functional outcomes after ileal pouch-anal …
Mechanism study of acupuncture and acupuncture combined with medication in the treatment of ulcerative colitis
Publication Year: 2025 Source: Physiol Res PMID: 40698655
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder. Currently, the global incidence of UC has significantly increased. Traditional treatment methods are relatively limited, with generally poor efficacy and many side effects. In contrast, acupuncture holds great promise due to its significant efficacy, reduced relapse rate, and minimal side effects. …
Impact of diet on inflammatory bowel disease risk: systematic review, meta-analyses and implications for prevention
Publication Year: 2025 Source: EClinicalMedicine PMID: 40697960
BACKGROUND: Data on dietary risk factors for inflammatory bowel disease (IBD), while extensive, are inconsistent. Our aim was to systematically review and meta-analyze available data unraveling the relationship between diet and IBD subtypes, Crohn's disease (CD) and ulcerative colitis (UC). METHODS: We conducted a systematic literature review following PRISMA guidelines, …
The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40697820
INTRODUCTION: Ulcerative colitis (UC) is a chronic gastrointestinal disease characterized by symptoms of abdominal pain and diarrhea. Chymase is a serine protease released by the mast cells and is highly expressed in patients with UC. However, its role in disease pathogenesis remains poorly understood. In mice, mast cell protease-4 (MCP-4) …
Oral vancomycin is associated with less therapy intensification in adults with symptomatic inflammatory bowel disease and underlying primary sclerosing cholangitis
Publication Year: 2025 Source: Ann Gastroenterol PMID: 40697439
BACKGROUND: Case reports describe the use of oral vancomycin therapy (OVT) in adult patients with concomitant symptomatic inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC). OVT is associated with a higher likelihood of IBD remission in pediatric IBD-PSC patients. However, there are limited data on the association between OVT …
Exploring the competencies of inflammatory bowel disease nurses in Italy: a cross-sectional survey
Publication Year: 2025 Source: Ann Gastroenterol PMID: 40697430
BACKGROUND: Nurses are essential in the care of patients with inflammatory bowel disease (IBD). However, the competencies of IBD nurses in Italy still need to be studied. This research assessed Italian IBD nurses' fundamental and advanced skills, providing a baseline for future professional development. METHODS: This cross-sectional study used an …
Increased Fiber Intake Enhances Clostridia Bacteria and Reduces Clinical Relapse in Patients With Clinically Quiescent Inflammatory Bowel Disease: A Prospective Longitudinal Study
Publication Year: 2025 Source: JGH Open PMID: 40697428
BACKGROUND AND AIM: A high-fiber, low-animal-protein, and low-saturated-fat diet may modulate gut dysbiosis and benefit inflammatory bowel disease (IBD). This study investigated the effects of this diet on clinical relapses, fecal calprotectin, and gut microbiota in patients with clinically quiescent IBD. METHODS: Sixty-one patients with IBD were enrolled (23 Crohn's …
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