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KB-0118, A novel BET bromodomain inhibitor, suppresses Th17-mediated inflammation in inflammatory bowel disease
Publication Year: 2025 Source: Biomed Pharmacother PMID: 40088776 DOI: 10.1016/j.biopha.2025.117933
Inflammatory bowel disease (IBD) presents complex pathologies and remains challenging to treat, highlighting the urgent need for innovative therapeutics. This study evaluates KB-0118, a novel BET bromodomain inhibitor targeting BRD4, for its immunomodulatory effects in IBD. KB-0118 effectively inhibited pro-inflammatory cytokines, including TNF, IL-1beta, and IL-23a, and selectively suppressed Th17 …
Effects of three Chinese herbal therapies on gut microbiota and short-chain fatty acid metabolism in patients with mild, moderate, and severe ulcerative colitis: Multi-center, randomized, controlled trials
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40088871
BACKGROUND: Traditional Chinese medicines, as a burgeoning field of medication, significantly alleviate ulcerative colitis (UC) by improving intestinal microbiota-metabolism. Our previous studies demonstrated the significant efficacy of Hudi Enteric-coated capsules (HDEC), Qingchang Wenzhong decoction (QCWZ), and Modified Wumei pill (MWMP) using a mouse model of colitis. However, the mechanism of …
Guselkumab in moderately to severely active ulcerative colitis: Another interleukin-23p19 subunit inhibitor or more?
Publication Year: 2025 Source: Med PMID: 40088885 DOI: 10.1016/j.medj.2025.100605
The QUASAR clinical development program evaluated the efficacy of guselkumab-an IL-23p19 subunit inhibitor-for the treatment of moderate-to-severe ulcerative colitis.(1) Guselkumab demonstrated rapid control of symptoms, as well as significant rates of objective disease remission. However, real-world evidence will be crucial to confirm these findings in patient subgroups that were not …
Enteric nervous system dysfunction as a driver of central nervous system disorders: The Forgotten brain in neurological disease
Publication Year: 2025 Source: Neuroscience PMID: 40088964 DOI: 10.1016/j.neuroscience.2025.03.015
The Enteric Nervous System (ENS), often called the "second brain," is a complex network of neurons and glial cells within the gastrointestinal (GI) tract. It functions autonomously while maintaining close communication with the central nervous system (CNS) via the gut-brain axis (GBA). ENS dysfunction plays a crucial role in neurodegenerative …
The probiotic enhances donor microbiota stability and improves the efficacy of fecal microbiota transplantation for treating colitis
Publication Year: 2025 Source: J Adv Res PMID: 40089059 DOI: 10.1016/j.jare.2025.03.017
INTRODUCTION: The stability and metabolic functionality of donor microbiota are critical determinants of fecal microbiota transplantation (FMT) efficacy in inflammatory bowel disease (IBD). While probiotics show potential to enhance microbiota resilience, their role in optimizing donor microbiota for FMT remains underexplored. OBJECTIVES: This study investigated whether pretreatment of donor microbiota …
Exploring biomarkers of systemic oxidative stress and placental insufficiency in pregnant women with inflammatory bowel diseases
Publication Year: 2025 Source: Free Radic Biol Med PMID: 40089080 DOI: 10.1016/j.freeradbiomed.2025.03.017
BACKGROUND: Inflammatory bowel disease (IBD) often presents during the fertile age and may affect pregnancy outcomes. Both IBD and selected pregnancy complications involve oxidative stress. Soluble FMS-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) serve as biomarkers of placental insufficiency, while free thiols (FT) reflect systemic oxidative stress. This …
Diagnostic values of CD27, CD20 and MPO in pediatric ulcerative colitis
Publication Year: 2025 Source: Gene PMID: 40089083 DOI: 10.1016/j.gene.2025.149415
Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a chronic inflammatory disorder with a rising incidence in pediatric populations. Immune factors play important roles in the pathogenesis of UC. This study aimed to explore the relationships of intestinal immune molecules CD27, CD20 and myeloperoxidase (MPO) with pediatric UC and …
The case of a bloody mess - Bictegravir/emtricitabine/tenofovir alafenamide induced colitis
Publication Year: 2025 Source: Clin Biochem PMID: 40089176 DOI: 10.1016/j.clinbiochem.2025.110910
BACKGROUND: Fecal calprotectin is a marker used to differentiate inflammatory bowel disease versus irritable bowel syndrome and is relevant in the diagnosis of ulcerative colitis and Crohn's disease. Markedly elevated calprotectin from stool samples provides evidence of colonic inflammation to support the diagnosis of pancolitis. This report is the first …
Risk of Age-related and Disease-related Complications and Mortality in Elderly-onset Inflammatory Bowel Disease - A Population-based Study
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40089251 DOI: 10.1016/j.cgh.2025.01.020
BACKGROUND & AIMS: In this nationwide cohort from Israel (Epi-IIRN), we aimed to characterize risks for age-related complications, mortality, and inflammatory bowel disease (IBD)-related surgeries in patients with elderly-onset IBD (EO-IBD). METHODS: Data of patients with EO-IBD (>/=65 years) diagnosed during 2005 to 2020 were retrieved from the epi-IIRN database. …
Biosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease
Publication Year: 2025 Source: Nat Commun PMID: 40089457 DOI: 10.1038/s41467-025-57890-8
The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development of inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. The chiral nanomedicines include four functional …
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