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Bakuchiol mitigates colitis through GPR120 activation
Publication Year: 2025 Source: Phytomedicine PMID: 40085989 DOI: 10.1016/j.phymed.2025.156618
BACKGROUND: Sishen Wan (SSW) is a traditional herbal formula widely used in China to treat inflammatory bowel disease (IBD). However, effective compound(s) and the mechanism(s) of action remain mostly unelucidated. PURPOSE: A demonstration study was carried out to identify the main components of SSW, investigate its effects, and explore the …
Dietary succinate supplementation alleviates DSS-induced colitis via the IL-4Rα/Hif-1α Axis
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40086056 DOI: 10.1016/j.intimp.2025.114408
Inflammatory bowel disease (IBD) remains a pressing global health challenge, necessitating novel therapeutic strategies. Succinate, a metabolite known for its role in type 2 immunity and tuft cell activation in the small intestine, presents its potential in IBD management. However, its impact on colonic inflammation has not been explored. Here, …
Indole-3-propionic acid alleviates DSS-induced colitis in mice through macrophage glycolipid metabolism
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40086057
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease for which current therapeutic approaches still face many dilemmas, and targeting macrophage polarization and metabolism for the treatment of this disease is a potentially effective strategy. The gut microbial metabolite indole-3-propionic acid (IPA) has favorable anti-inflammatory and antioxidant effects and …
The intestinal barrier: a pivotal role in health, inflammation, and cancer
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40086468
The intestinal barrier serves as a boundary between the mucosal immune system in the lamina propria and the external environment of the intestinal lumen, which contains a diverse array of microorganisms and ingested environmental factors, including pathogens, food antigens, toxins, and other foreign substances. This barrier has a central role …
Incorporating Best-Worst Scaling (BWS) Questions into Focus Groups to Improve Understanding of Patient Preferences and Refine BWS Attributes
Publication Year: 2025 Source: Patient PMID: 40087217
BACKGROUND AND OBJECTIVE: Best-worst scaling (BWS) is a stated preference elicitation method used for prioritizing attributes of healthcare interventions. Best-worst scaling attribute development is commonly based on literature review, qualitative work, and methodological/clinical expert input. There is limited research incorporating BWS in focus groups as part of the attribute development …
Deep representation learning for clustering longitudinal survival data from electronic health records
Publication Year: 2025 Source: Nat Commun PMID: 40087274
Precision medicine requires accurate identification of clinically relevant patient subgroups. Electronic health records provide major opportunities for leveraging machine learning approaches to uncover novel patient subgroups. However, many existing approaches fail to adequately capture complex interactions between diagnosis trajectories and disease-relevant risk events, leading to subgroups that can still display …
T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40087977 DOI: 10.1093/ecco-jcc/jjaf043
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous …
Further Insights Into the Educational and Career Impact of Pediatric-Onset IBD
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40088201 DOI: 10.1002/ueg2.70016
No Abstract
The efficacy, safety, and persistence of vedolizumab versus adalimumab in patients with inflammatory bowel disease: a systematic review and meta-analysis
Publication Year: 2025 Source: Inflammopharmacology PMID: 40088372 DOI: 10.1007/s10787-025-01710-4
PURPOSE: This systematic review and meta-analysis compared the efficacy, safety, and treatment persistence of vedolizumab and adalimumab in patients with inflammatory bowel disease (IBD). METHODS: Through a comprehensive search of three databases up to September 2024, we calculated pooled effect estimates for binary outcomes using risk ratios (RR) with 95% …
Quercetin protected the gut barrier in ulcerative colitis by activating aryl hydrocarbon receptor
Publication Year: 2025 Source: Phytomedicine PMID: 40088746
BACKGROUND: Ulcerative colitis (UC) is characterized by abdominal pain and bloody diarrhoea and restoring the gut barrier is the core goal of UC treatment. Activation of aryl hydrocarbon receptor (Ahr) was reported to effectively alleviate symptoms and repair the gut barrier damage. Neutrophil extracellular traps (NETs) have been recognized as …
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