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Duodenal Peptic Ulcer Perforation in the Puerperium Case Report Series
Publication Year: 2025 Source: AJP Rep PMID: 40041136
Peptic ulcers and complications, such as perforation, are rare during pregnancy and the puerperium. Accordingly, many clinicians may place these diagnoses low on their differential diagnosis. We present two case reports of primigravida, advanced maternal-age females with a history of irritable bowel syndrome and nonsteroidal anti-inflammatory drug use found to …
Reducing diagnostic delays of extraintestinal manifestations in inflammatory bowel disease: a comparative study of a multidisciplinary outpatient clinic versus conventional referral specialists
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40041240 DOI: 10.1177/17562848251323529
BACKGROUND: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. …
Epstein-Barr virus infection exacerbates ulcerative colitis by driving macrophage pyroptosis via the upregulation of glycolysis
Publication Year: 2025 Source: Precis Clin Med PMID: 40041420
BACKGROUND: Epstein-Barr virus (EBV) infection is associated with clinical symptoms, treatment response, need for surgical intervention, and an enhanced likelihood of lymphoma among patients with ulcerative colitis (UC). However, existing studies have primarily concentrated on the epidemiological and clinical associations between EBV and UC, leaving the mechanisms by which EBV …
Targeting gut microbiota dysbiosis in inflammatory bowel disease: a systematic review of current evidence
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40041456 DOI: 10.3389/fmed.2025.1435030
INTRODUCTION: The dysbiosis of the gut microbiota has been identified as a central factor in the pathogenesis of inflammatory bowel disease (IBD), a chronic condition characterized by frequent recurrence and various adverse effects of traditional therapies. While treatments targeting the gut microbiota show promise, their efficacy in IBD management still …
Familial Mediterranean Fever Intertwined With a Diagnosis of Crohn's Disease: A Case Report
Publication Year: 2025 Source: Cureus PMID: 40041636
Autoinflammatory diseases are a group of disorders caused by the dysregulation of the innate immune system, leading to episodes of systemic inflammation, with familial Mediterranean fever (FMF) being the most common among them. Other inflammatory disorders have recently been associated with FMF, including inflammatory bowel disease, specifically Crohn's disease (CD). …
Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis
Publication Year: 2025 Source: Jpn Dent Sci Rev PMID: 40041882 DOI: 10.1016/j.jdsr.2025.02.001
The bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to August 2024 to identify relevant studies. The relative risk (RR) from periodontal disease studies and the decayed, missing, …
Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
Publication Year: 2025 Source: Acta Pharm Sin B PMID: 40041889
No Abstract
Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation
Publication Year: 2025 Source: Acta Pharm Sin B PMID: 40041900 DOI: 10.1016/j.apsb.2024.11.009
Disruption of the intestinal mucosal barrier caused by gut dysbiosis and metabolic imbalance is the underlying pathology of inflammatory bowel disease (IBD). Traditional Chinese medicine Wuji Wan (WJW) is commonly used to treat digestive system disorders and showed therapeutic potential for IBD. In this interdisciplinary study, we aim to investigate …
Microbial Butyrate Modified by Melatonin Alleviates Colon Inflammation by Inhibiting GPR109A/Caspase-1-Dependent Macrophage M1 Polarization
Publication Year: 2025 Source: J Proteome Res PMID: 40042189
Recurrent ulcerative colitis (UC) seriously affects the quality of life of patients. Melatonin affects the alteration of the gut microbiota and can effectively relieve inflammation-associated diseases. In the present study, we determined that melatonin effectively alleviated intestinal inflammation and delayed weight loss in mice. Analysis of ileocecal contents in mice …
Correction: Olteanu et al. Interleukin-4 Gene Polymorphisms in Romanian Patients with Inflammatory Bowel Diseases: Association with Disease Risk and Clinical Features. Diagnostics 2023, 13, 1465
Publication Year: 2025 Source: Diagnostics (Basel) PMID: 40042385
The authors wish to correct the authorship of the original publication [...].
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