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Colonic Diaphragmatic Disease: The Concerning Dark Depths of NSAIDs
Publication Year: 2025 Source: Dig Dis Sci PMID: 40042563
Non-steroidal anti-inflammatory drugs (NSAIDs), widely used for their therapeutic benefits, are associated with significant gastrointestinal complications, including the rare occurrence of colonic diaphragm disease (CDD). Characterized by diaphragm-like fibrotic strictures that narrow the intestinal lumen, CDD often leads to symptoms such as chronic anemia, bowel obstruction, and gastrointestinal bleeding. This …
The Effect of Disclosure on Enacted Stigma Towards Individuals with Inflammatory Bowel Disease
Publication Year: 2025 Source: J Clin Psychol Med Settings PMID: 40042773 DOI: 10.1007/s10880-025-10070-8
Individuals with inflammatory bowel disease (IBD) often experience stigmatization. Disease disclosure has been associated with lower enacted stigma (i.e., engaging in discriminatory treatment), but minimal research has investigated IBD disclosure and enacted stigma experimentally. The present study's aim was to examine the effect of IBD disclosure on enacted stigma in …
Clinical Features in Patients With Early-Onset Colorectal Cancer: An Evaluation of Data From the StuDoQ Database
Publication Year: 2025 Source: Dtsch Arztebl Int PMID: 40043210
BACKGROUND: The incidence of colorectal cancer (CRC) in patients who are less than 50 years old (early-onset colorectal cancer, EO-CRC) has risen markedly around the world in recent decades. Because of a lack of early detection programs for young patients, EO-CRC is often not detected until it has reached an …
Antibiotic drug use in the five years preceding the diagnosis of multiple sclerosis
Publication Year: 2025 Source: Mult Scler Relat Disord PMID: 40043555
BACKGROUND: Microbiota may play a role in autoimmune disease pathogenesis, including multiple sclerosis (MS). Antibiotic use disrupts the microbiome and may increase the risk of autoimmune diseases. We evaluated the relationship between MS diagnosis and antibiotic, antimycotic and antiviral drug use in the 5 years preceding diagnosis. METHOD: Our population-based …
[Correction: Position paper of the Society for Paediatric Gastroenterology and Nutrition (GPGE) on the off-label use of biologics and signal inhibitors in children and adolescents with IBD that have already been approved for adults]
Publication Year: 2025 Source: Z Gastroenterol PMID: 40043724 DOI: 10.1055/a-2543-1671
No Abstract
Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40043824
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammation-to-cancer transformation is critical for the progression of ulcerative colitis to colitis-associated colorectal cancer (CAC). AIM OF THE STUDY: To explore the role and potential mechanisms of Qingre Huayu Jianpi prescription (QHJ) treatment in the development of CAC. MATERIALS AND METHODS: Combined network pharmacology and transcriptome analyses were …
Explore the key targets and mechanism of Danggui Buxue decoction against ulcerative colitis: Network pharmacology and experimental validation
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40043827
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese herbal formula, Danggui Buxue decoction (DBD), is known for its ability in tonifying Qi and promoting the production of blood. It is extensively utilized in treating menstrual anemia and chronic non-healing ulcers. Whereas the impact of DBD on ulcerative colitis (UC) has not been explored, …
Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications
Publication Year: 2025 Source: Food Chem Toxicol PMID: 40043936 DOI: 10.1016/j.fct.2025.115369
Natural compounds have garnered significant attention as potential therapeutic agents due to their inherent properties. Their notable qualities, including safety, efficacy, favorable pharmacokinetic properties, and heightened effectiveness against certain diseases, particularly inflammatory conditions, make them particularly appealing. Among these compounds, curcumin has attracted considerable interest for its unique therapeutic properties …
Analysis of confounders of the image quality of a high-resolution isotropic three-dimensional Dixon water-fat late gadolinium enhancement technique
Publication Year: 2025 Source: J Cardiovasc Magn Reson PMID: 40043957
BACKGROUND: Three-dimensional (3D) water-fat separated late gadolinium enhancement (LGE) imaging is a cardiovascular magnetic resonance imaging technique allowing simultaneous assessment of and discrimination between cardiac fibrosis and myocardial fatty infiltration. The aim of this study is to systematically analyze the image quality of a 3D water-fat separated LGE research sequence …
Dextran sulfate-coated curcumin nanocrystals for the treatment of DSS-induced ulcerative colitis in mice
Publication Year: 2025 Source: Int J Pharm PMID: 40043963
Ulcerative colitis is an inflammatory disease that primarily involves intestinal inflammation and epithelial damage. The nano-targeted drug delivery system delivers drugs to the disease site, exerting effects such as inhibiting inflammatory response and reducing reactive oxygen species expression, thereby promoting recovery from ulcerative colitis. In this experiment, dextran sulfate-coated curcumin …
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