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Systematic review and meta-analysis of post-traumatic stress disorder as a risk factor for multiple autoimmune diseases
Publication Year: 2025 Source: Front Psychiatry PMID: 40051767 DOI: 10.3389/fpsyt.2025.1523994
BACKGROUND: Post Traumatic Stress Disorder (PTSD) is a prevalent and debilitating psychiatric illness that has been linked to poor health outcomes and increased risk of developing chronic health conditions, including multiple autoimmune diseases such as Systemic Lupus Erythematosus (SLE), Inflammatory Bowel Disease (IBD), Rheumatoid Arthritis (RA), and Multiple Sclerosis (MS). …
Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population
Publication Year: 2025 Source: Front Pediatr PMID: 40051907 DOI: 10.3389/fped.2025.1487253
BACKGROUND: There is a paucity of knowledge on disease phenotype and outcome of very early-onset (VEO) inflammatory bowel disease (VEO-IBD) from recently developed and developing countries, including from Southeast Asia. We studied disease phenotype, clinical characteristics, management and outcome of VEO-IBD in South and Southeast Asian children. MATERIALS AND METHODS: …
Inflammatory Bowel Disease in Children: Current Diagnosis and Treatment Strategies
Publication Year: 2025 Source: Cureus PMID: 40051947 DOI: 10.7759/cureus.78462
Pediatric inflammatory bowel disease (PIBD), including Crohn's disease and ulcerative colitis, has emerged as a significant global health challenge with rising incidence rates. Unlike adult inflammatory bowel disease, PIBD presents complexities, including growth impairment, nutritional deficiencies, and psychosocial challenges that necessitate tailored management strategies. This article reviews current diagnostic and …
Long-distance gene flow and recombination shape the evolutionary history of a maize pathogen
Publication Year: 2025 Source: IMA Fungus PMID: 40052074 DOI: 10.3897/imafungus.16.138888
The evolutionary history of crop pathogens is shaped by a complex interaction of natural and anthropogenic factors. The fungus Colletotrichumgraminicola causes maize anthracnose which results in significant yield losses worldwide. We conducted a comprehensive investigation into the evolutionary genomics of C.graminicola using a collection of 212 isolates from 17 countries …
Pain Trajectories in Pediatric Inflammatory Bowel Disease: Disease Severity, Optimism, and Pain Self-efficacy
Publication Year: 2025 Source: Clin J Pain PMID: 40052200 DOI: 10.1097/AJP.0000000000001279
OBJECTIVES: This study aimed to characterize pain intensity (average, worst) and disease severity in youth with inflammatory bowel disease in the 12-month postdiagnosis, and to examine the relation between pain and risk (disease severity) and resilience (optimism, pain self-efficacy) factors over time. METHODS: Data collection ran from February 2019 to …
The Role of IgE in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate FOXP3(+) Tregs
Publication Year: 2025 Source: Allergy PMID: 40052502
BACKGROUND: A causal relationship between Crohn's disease (CD) and asthma is reported, but the underlying mechanisms are not fully understood. We sought to investigate the role of IgE and IgE-mediated pathways in the pathophysiology of CD. METHODS: 20 CD patients, 10 allergic patients without inflammatory bowel disease, and 10 healthy …
Artificial intelligence-assisted approach to assessing bowel wall thickness in pediatric inflammatory bowel disease using intestinal ultrasound images
Publication Year: 2025 Source: J Crohns Colitis PMID: 40052532 DOI: 10.1093/ecco-jcc/jjaf037
BACKGROUND AND AIM: Intestinal ultrasound (IUS) potentially spares patients from repeated endoscopies under sedation and eliminates the need for alternative imaging modalities like magnetic resonance enterography and computed tomography enterography scans. However, interpreting IUS images is challenging for physicians due to the time-intensive process of identifying markers indicative of inflammatory …
Multimodal metagenomic analysis reveals microbial InDels as superior biomarkers for pediatric Crohn's disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40052570
BACKGROUND AND AIMS: The gut microbiome is closely associated with pediatric Crohn's disease (CD), while the multidimensional microbial signature and their capabilities for distinguishing pediatric CD are underexplored. This study aims to characterize the microbial alterations in pediatric CD and develop a robust classification model. METHODS: A total of 1175 …
FECAL CALPROTECTIN AND INTESTINAL METABOLITES: WHAT IS THEIR IMPORTANCE IN THE ACTIVITY AND DIFFERENTIATION OF PATIENTS WITH INFLAMMATORY BOWEL DISEASES?
Publication Year: 2025 Source: Arq Bras Cir Dig PMID: 40052996 DOI: 10.1590/0102-6720202500001e1870
BACKGROUND: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), lacks a known etiology. Although clinical symptoms, imaging, and colonoscopy are common diagnostic tools, fecal calprotectin (FC) serves as a widely used biomarker to track disease activity. Metabolomics, within the omics sciences, holds promise for identifying disease …
Pain, opioid consumption, and epidural anesthesia in patients with inflammatory bowel disease undergoing laparoscopic subtotal colectomy: an observational cohort study
Publication Year: 2025 Source: Tech Coloproctol PMID: 40053149
BACKGROUND: Surgery is often needed to provide disease control in patients with inflammatory bowel disease. Studies document increased postoperative pain and complicated perioperative courses. This study examines postoperative pain and opioid consumption in patients with inflammatory bowel disease undergoing laparoscopic subtotal colectomy. Furthermore, the impact of epidural anesthesia is investigated. …
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