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The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential
Publication Year: 2025 Source: Gut Microbes PMID: 40050613
This review explores the emerging term "gut-skin axis" (GSA), describing the bidirectional signaling that occurs between the skin and the gastrointestinal tract under both homeostatic and disease conditions. Central to GSA communication are the gut and skin microbiota, the microbial communities that colonize these barrier surfaces. By influencing diverse host …
The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40050710 DOI: 10.1186/s12876-025-03691-8
BACKGROUND: Depression is common in people living with Inflammatory Bowel Disease (IBD). Depression rates increase with active disease and are linked to poorer clinical outcomes. Previous studies investigating the relationship between contemporaneous IBD disease activity and depression are often poorly controlled, use small samples and/or rely on self-reported measures of …
Effect of montelukast on remission maintenance in patients with ulcerative colitis: a Randomized, double-blind controlled clinical trial
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40050744
BACKGROUND: Considering the role of leukotrienes in inflammatory pathways, and owing to the anti-leukotrienes effect of montelukast, in the present clinical trial, we aimed to assess the effect of montelukast on remission maintenance in patients with ulcerative colitis (UC). METHODS: In the present double-blind randomized controlled clinical trial, 222 volunteer …
Association between avoidant/restrictive food intake disorder risk, dietary attitudes and behaviors among Chinese patients with inflammatory bowel disease: a cross-sectional study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40050745 DOI: 10.1186/s12876-025-03727-z
BACKGROUND: Restrictive eating behaviors are common among patients with inflammatory bowel disease (IBD), which may may develop nutritional and/or quality of life impairments into avoidant/restrictive food intake disorder (ARFID). The objective of this study is to estimate the prevalence and characteristics of ARFID in Chinese patients with IBD, and to …
Relationship between venous thromboembolism and inflammatory bowel disease in Taiwan: a nationwide retrospective cohort study
Publication Year: 2025 Source: BMC Cardiovasc Disord PMID: 40050756 DOI: 10.1186/s12872-025-04600-3
BACKGROUND: Inflammation significantly influences thrombosis development, with venous thromboembolism (VTE) risk linked to various systemic inflammatory diseases, but not fully established in inflammatory bowel disease (IBD). Using a population-based cohort study conducted in Taiwan, we investigated the impact of IBD on the risk of VTE, deep vein thrombosis (DVT), and …
Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn's disease: a prospective trial
Publication Year: 2025 Source: J Transl Med PMID: 40050917
BACKGROUND: Clinical data on oral fecal microbiota transplantation (FMT), a promising therapy for Crohn's disease (CD), are limited. Herein, we determined the short-term safety and feasibility of FMT for pediatric patients with active CD. METHODS: In this open-label, parallel-group, single-center prospective trial, patients with active CD were treated with oral …
Impact of gastrointestinal and psychological symptoms on disease activity and functional impairment in patients with spondyloarthritis: a cross-sectional study
Publication Year: 2025 Source: BMC Rheumatol PMID: 40050979 DOI: 10.1186/s41927-025-00478-y
INTRODUCTION: Spondyloarthritis (SpA) exhibits predominantly musculoskeletal symptoms but also significant gastrointestinal (GI) and psychological manifestations. Subclinical gut inflammation is common in SpA, with frequent symptoms such as abdominal pain and diarrhea. Psychological issues like depression and anxiety are also prevalent, with a negative impact on quality of life. This study …
Culture-based characterization of gut microbiota in inflammatory bowel disease
Publication Year: 2025 Source: Front Microbiol PMID: 40051478 DOI: 10.3389/fmicb.2025.1538620
Inflammatory bowel disease (IBD) is characterized by disruptions in the gut microbiome. While most studies on gut dysbiosis in IBD rely on sequencing-based methods, we employed a streamlined culturomics approach to obtain a more comprehensive understanding of gut microbiota imbalance in patients with IBD that may not be captured by …
Factors affecting the efficacy of small bowel capsule endoscopy in patients with chronic abdominal pain
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40051571
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Differential transcript and soluble factor patterns in macrophage/enterocyte-like monolayer co-cultures based on apical or basolateral LPS exposure
Publication Year: 2025 Source: Front Immunol PMID: 40051635 DOI: 10.3389/fimmu.2025.1527007
BACKGROUND: The monolayer of intestinal epithelial cells (IECs) plays a crucial role in controlling intestinal homeostasis, also by its interaction with the immune system, via paracrine cytokine production, thus driving innate responses by tissue-resident immune cells. Here, using a co-culture model, we investigated the interactions between differentiated Caco-2 cells in …
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