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Extracellular Vesicles From Lactobacillus fermentum Enhance Intestinal Barrier Integrity and Restore Gut Microbial Homeostasis in Experimental Murine Colitis
Publication Year: 2025 Source: J Nutr PMID: 40058701
BACKGROUND: Lactobacillus fermentum has been shown to improve intestinal health and treat colitis; however, its precise efficacy and mechanisms in inflammatory bowel disease remain unclear. OBJECTIVES: This study aimed to evaluate whether L fermentum and its metabolites, extracellular vesicles, and other components could modulate intestinal barrier function and gut microbiota …
Real-World Effectiveness and Safety of Upadacitinib in Crohn's Disease: A Multicenter Study
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40058746 DOI: 10.1016/j.cgh.2025.01.012
BACKGROUND & AIMS: We aimed to describe the real-world effectiveness and safety of upadacitinib (UPA), an oral Janus kinase 1 inhibitor, in patients with Crohn's disease (CD). METHODS: A retrospective analysis was conducted across 9 centers in the United States, focusing on adults with CD treated with UPA, 45 mg, …
To Treat or Not to Treat - Prospection and Prognosis in IBD
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40058747 DOI: 10.1016/j.cgh.2025.01.013
No Abstract
[Short bowel syndrome (SBS)]
Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40058801
No Abstract
[Short bowel syndrome in children]
Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40058802 DOI: 10.11405/nisshoshi.122.160
No Abstract
[Efforts to reduce parenteral support in short bowel syndrome]
Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40058804
No Abstract
[Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease]
Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40058806 DOI: 10.11405/nisshoshi.122.196
Iron deficiency anemia (IDA) is a prevalent complication in patients with inflammatory bowel disease (IBD). Ferric carboxymaltose (FCM) is a new intravenous iron formation that has been available for IDA in Japan since 2020. The present study aimed to investigate the efficacy and safety of FCM in patients with IBD …
Assessment of adhering and invading properties of Escherichia coli strains
Publication Year: 2025 Source: Methods Cell Biol PMID: 40058959 DOI: 10.1016/bs.mcb.2024.08.011
Gastrointestinal infections, caused by Enterobacteriaceae, pose a major global health challenge, resulting in significant morbidity and mortality. Enhanced adherence and invasion properties are widespread among enteric pathogenic species, particularly those linked to invasive infections such as some pathovars of Escherichia coli or pathogens like Shigella and Salmonella. Pathogenic E. coli …
Severe anemia predisposes very premature infants to transfusion-associated necrotizing enterocolitis
Publication Year: 2025 Source: Semin Fetal Neonatal Med PMID: 40059009
Necrotizing enterocolitis (NEC) is a catastrophic inflammatory bowel necrosis of premature infants. The etiology is unknown, but 25-40 % of cases have a history of red blood cell (RBC) transfusions in the preceding 48 h. This association has been noted in retrospective case/case-control studies, and many meta-analyses, and in a …
Lacidophilin tablets relieve irritable bowel syndrome in rats by regulating gut microbiota dysbiosis and intestinal inflammation
Publication Year: 2025 Source: Sci Rep PMID: 40059226
Irritable bowel syndrome (IBS) is a common clinical functional gastrointestinal disease. It has a complex pathophysiological mechanism, in which the imbalance of gut microbiota might play an important role. Lacidophilin tablets (LH) can regulate gut microbiota, but their effect on IBS is unknown. In this study, the IBS model was …
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