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Identification and characteristics of patients with axial psoriatic arthritis: clinical, phenotypic, and imaging associations
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 40059325
OBJECTIVE: To present the clinical and imaging characteristics of patients with Axial Psoriatic Arthritis (PsA) and to identify possible subtypes. METHODS: Data were retrieved from the Greek-multicentre PsA study. Axial PsA (axPsA) was defined as PsA (CASPAR criteria) accompanied by inflammatory back pain (present or ever) and positive imaging findings …
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches
Publication Year: 2025 Source: J Drug Target PMID: 40059545
Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it easily relapses, thus, providing a considerable threat to human health. A number of inflammatory mediators, oxidative stress and role of …
Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn's disease
Publication Year: 2025 Source: JCI Insight PMID: 40059828
Crohn's disease (CD) involves a complex intestinal microenvironment driven by chronic inflammation. While single-cell RNA sequencing has provided valuable insights into this biology, the spatial context is lost during single-cell preparation of mucosal biopsies. To deepen our understanding of the distinct inflammatory signatures of CD and overcome the limitations of …
Biologics in the management of pediatric inflammatory bowel disease: When and what to choose
Publication Year: 2025 Source: World J Clin Pediatr PMID: 40059900
Pediatric inflammatory bowel disease (PIBD) is a chronic inflammatory disorder of the gastrointestinal tract, with rising global incidence and prevalence. Over the past two decades, biologics have added to the therapeutic armamentarium and revolutionized the approach to treatment of inflammatory bowel disease. The available biologics include monoclonal antibodies which target …
Inflammatory Bowel Disease and Colorectal Cancer: An Eternal Fire in a Beautiful Garden
Publication Year: 2025 Source: South Asian J Cancer PMID: 40060342 DOI: 10.1055/s-0045-1802335
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, significantly increases the risk of colitis-associated cancer (CAC). Chronic inflammation, a key contributor to carcinogenesis, disrupts immune surveillance, induces deoxyribonucleic acid (DNA) damage, and alters genetic and epigenetic pathways. Molecular pathways such as STAT3, mTOR, and NF-kappaB drive CAC progression, …
Estimating gene conversion rates from population data using multi-individual identity by descent
Publication Year: 2025 Source: bioRxiv PMID: 40060563 DOI: 10.1101/2025.02.22.639693
In humans, homologous gene conversions occur at a higher rate than crossovers, however gene conversion tracts are small and often unobservable. As a result, estimating gene conversion rates is more difficult than estimating crossover rates. We present a method for multi-individual identity-by-descent (IBD) inference that allows for mismatches due to …
Amorphophallus konjac: traditional uses, bioactive potential, and emerging health applications
Publication Year: 2025 Source: Front Plant Sci PMID: 40061034
Amorphophallus konjac is a perennial plant native to Southeast Asia, renowned for its edible corms and rich nutritional value. The bioactive component, konjac glucomannan (KGM), has garnered significant attention due to its broad applications. This review aims to provide a comprehensive overview of the traditional uses, chemical and physical properties, …
Perianal fistulizing Crohn's disease: Mechanisms and treatment options focusing on cellular therapy
Publication Year: 2025 Source: World J Gastroenterol PMID: 40061590
Perianal fistulizing Crohn's disease (PFCD) is a common presentation of CD, which affects the patients' quality of life, including social and sexual function. The management of PFCD remains a critical challenge in inflammatory bowel disease, primarily due to limited understanding of the mechanisms involved in its pathogenesis, complicating medical treatment. …
Strengths, weaknesses, opportunities, and threats analysis of combination therapy for inflammatory bowel disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 40061596 DOI: 10.3748/wjg.v31.i9.100607
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, manifests as a chronic, recurrent, and refractory intestinal inflammatory condition significantly impacting patients' quality of life. Despite ongoing research, its etiology and pathogenesis remain incompletely understood. Recent advancements in medical research highlight the critical role of drug combination therapies in …
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis
Publication Year: 2025 Source: World J Gastroenterol PMID: 40061598
BACKGROUND: Ulcerative colitis (UC), a chronic and challenging condition, necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications. Traditional Chinese medicine (TCM), known for its multi-stage and multi-targeted approach, has a long history in treating gastrointestinal diseases and offering a …
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