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Comparison of 1-Year Clinical Course in Patients With Newly Diagnosed Inflammatory Bowel Disease Between Vietnam and Korea: A Multinational, Multicenter Retrospective Cohort Study
Publication Year: 2025 Source: JGH Open PMID: 39963126 DOI: 10.1002/jgh3.70106
BACKGROUND/AIMS: The differences in the clinical course of Crohn's disease (CD) and ulcerative colitis (UC) among Asian countries remain unknown. Thus, we compared the clinical characteristics, treatment, and one-year outcomes of newly diagnosed inflammatory bowel disease (IBD) patients between Vietnam and Korea. METHODS: A retrospective cohort study was conducted at …
Higher disease activity of inflammatory bowel disease predisposes to Clostridioides difficile infection
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39963249 DOI: 10.1177/17562848251318292
BACKGROUND: Clostridioides difficile infection (CDI) is a clinical challenge associated with poor outcomes in patients with inflammatory bowel disease (IBD). OBJECTIVES: To identify clinical risk factors for CDI and its recurrence among patients with IBD. DESIGN: Case-control cohort study of IBD patients with and without episodes of CDI. METHODS: A …
"Simpleness": a qualitative description study exploring patient perspectives on the barriers and facilitators of using digital health tools to self-manage inflammatory bowel disease
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39963250 DOI: 10.1177/17562848251319807
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic condition requiring lifelong management and frequent interactions with healthcare providers. Digital health tools have the potential to enhance disease management by providing real-time data and improving care coordination. Despite their potential, there is limited evidence on patient perspectives regarding barriers and facilitators …
Exploring the connection between erythrocyte membrane fatty acid composition and oxidative stress in patients undergoing the Crohn's disease Therapeutic Diet Intervention (CD-TDI)
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39963251 DOI: 10.1177/17562848251314827
BACKGROUND: Dietary fatty acids (FA) are crucial to the pathophysiology of inflammatory bowel disease (IBD), influencing systemic and gut inflammatory responses. Dietary FA intake influences the fatty acid profiles of vital cell membranes, which might be a source of inflammatory mediators. Despite their significance, research on dietary FA subtypes and …
Histone deacetylase in inflammatory bowel disease: novel insights
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39963253 DOI: 10.1177/17562848251318833
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society and human health, with increasing morbidity. Posttranslational modification, especially histone acetylation, is a key process in controlling DNA transcriptional activity. Histone deacetylases (HDACs) …
Neonatal necrotizing enterocolitis complicated by glutaric acidemia type II: a case report
Publication Year: 2025 Source: Front Pediatr PMID: 39963347
Glutaric acidemia type II (GAII) is an autosomal recessive genetic metabolic disorder associated with mitochondrial dysfunction, characterized by multiple acyl-CoA dehydrogenase deficiency that affects fatty acid metabolism. Necrotizing enterocolitis (NEC) represents a severe inflammatory condition affecting premature neonates. This report describes a case involving a male preterm infant born at …
Rapid Resolution of Perianal Crohn's Disease with Upadacitinib
Publication Year: 2025 Source: ACG Case Rep J PMID: 39963477
A 20-year-old woman with ileocolonic, stricturing, and penetrating Crohn's disease (CD) presented with new onset perianal and vulvar CD despite having a diverting ileostomy and medical therapy with ustekinumab. She had previous secondary nonresponse to infliximab, vedolizumab, and adalimumab. There is a paucity of data supporting the use of medical …
Multicenter Prospective Evaluation of Patient Radiation Exposure During Fenestrated-Branched Endovascular Aortic Repair: A Ten-year Experience
Publication Year: 2025 Source: Ann Surg PMID: 39963789 DOI: 10.1097/SLA.0000000000006676
OBJECTIVE: To assess patient radiation exposure as reflected by cumulative air kerma (CAK) and dose area product (DAP) during fenestrated-branched endovascular aortic repair (FB-EVAR). SUMMARY BACKGROUND DATA: Patient radiation exposure during FB-EVAR has been reported inconsistently. METHODS: Data from 2,111 patients enrolled in 10 physician-sponsored investigational device exemption studies (2012-2022) …
Dextran sodium sulfate-induced colitis-like gut permeability and dysbiosis in honeybees
Publication Year: 2025 Source: Insect Sci PMID: 39963925 DOI: 10.1111/1744-7917.13508
The gut microbiota has been linked to the pathophysiology of inflammatory bowel disease (IBD). Current animal models are limited in the generation of germ-free animals to evaluate the roles of gut bacteria in intestinal health. Here, we used the honeybee (Apis mellifera) as a model animal to develop colitis-like gut …
The role of immunogenicity in optimizing biological therapies for inflammatory bowel disease
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39964309 DOI: 10.1080/17474124.2025.2468302
INTRODUCTION: Immunogenicity of biologic agents for inflammatory bowel disease (IBD) is a critical issue, especially for tumor necrosis factor (TNF) inhibitors, where anti-drug antibodies (ADAs) significantly impact drug clearance, efficacy, and safety. Studies have demonstrated that non-TNF biologics tend to have lower susceptibility to immunogenicity, potentially offering advantages, especially in …
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