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Lactobacillus vaginalis alleviates DSS induced colitis by regulating the gut microbiota and increasing the production of 3-indoleacrylic acid
Publication Year: 2025 Source: Pharmacol Res PMID: 39961405
Ulcerative colitis (UC) is a chronic inflammatory disorder, and its incidence is experiencing an upward trend worldwide. UC can result in gut microbiota dysbiosis, impaired intestinal epithelial barrier, and systemic inflammation, for all of which there is presently no definitive treatment available. Lactobacillus is known to regulate gut microbiota and …
Chemotaxis-driven hybrid liposomes recover intestinal homeostasis for targeted colitis therapy
Publication Year: 2025 Source: J Control Release PMID: 39961435 DOI: 10.1016/j.jconrel.2025.02.036
Inflammatory bowel disease (IBD) is closely linked to the dysregulation of intestinal homeostasis, accompanied by intestinal epithelial barrier destruction, dysbiosis of gut microbiota, subsequent inflammatory factor infiltration, and excessive oxidative stress. Conventional therapeutics focus on suppressing inflammation and often suffer from metabolic instability as well as limited targeting, thereby leading …
High persistence rate at one year- follow-up of subcutaneous vedolizumab at standard dose after switching endovenous vedolizumab, even in those previously intensified: results of a Spanish multicentre observational study
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39961527 DOI: 10.1016/j.gastrohep.2025.502379
INTRODUCTION: Subcutaneous (sc) vedolizumab is an alternative to intravenous (iv) vedolizumab for the treatment of patients with mild-to-moderate flares of inflammatory bowel disease (IBD). AIMS: To analyse the persistence rate of the sc vedolizumab and its pharmacokinetics in patients previously treated with iv vedolizumab; describing clinical and biochemical remission rates …
Diagnostic and prognostic significance of Crohn's disease-like pathology in surgically diverted recta of patients with ulcerative colitis
Publication Year: 2025 Source: Histopathology PMID: 39961608 DOI: 10.1111/his.15429
AIMS: Diversion colitis (DC), commonly seen in surgically diverted bowel, can exhibit features resembling Crohn's disease (CD) even in patients with an established ulcerative colitis (UC). The superposition of DC on inflammatory bowel disease (IBD) complicates pathological assessment and potentially alters the diagnosis from UC to CD. We investigated the …
Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease
Publication Year: 2025 Source: Gut PMID: 39961646
BACKGROUND: Treatment strategies for Crohn's disease (CD) suppress diverse inflammatory pathways but many patients remain refractory to treatment. Autologous haematopoietic stem cell transplantation (SCT) is an emerging therapy for medically refractory CD though the mechanisms through which it circumvents refractory pathophysiology are unknown. OBJECTIVE: The objective of this study is …
Total fistula volume predicts surgical outcomes in complex perianal fistulizing Crohn's disease following fistula-tract laser closure: a single-center retrospective study
Publication Year: 2025 Source: Tech Coloproctol PMID: 39961900
BACKGROUNDS: This study aimed to identify risk factors influencing long-term treatment outcomes in patients with complex perianal fistulizing Crohn's disease (pfCD) following fistula-tract laser closure (FiLaC). METHODS: A retrospective analysis was conducted on data from patients with complex pfCD who underwent FiLaC from January 2019 to December 2020, including demographics, …
A patient-reported outcome measure comprising the stool frequency and abdominal pain items from the Crohn's Disease Activity Index: psychometric evaluation in adults with Crohn's disease
Publication Year: 2025 Source: J Patient Rep Outcomes PMID: 39962027
BACKGROUND: The Stool Frequency (SF) and Abdominal Pain (AP) items from the Crohn's Disease Activity Index are together referred to as the "Patient Reported Outcome" (PRO). The SF item measures the number of very soft/liquid stools and the AP item measures abdominal pain severity, which are common Crohn's disease (CD) …
Influence of biological sex in inflammatory bowel diseases
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 39962330 DOI: 10.1038/s41575-025-01038-y
The incidence of inflammatory bowel disease (IBD) has risen in the past decades and has emerged as a global health issue. IBD is characterized by chronic inflammation of the gastrointestinal tract. There is compelling evidence for the role of biological sex in IBD epidemiology, pathophysiology, disease progression, symptoms and extra-intestinal …
Is Health Status in Patients With Chronic Disorders of the Gastrointestinal System Disease-Specific? Results From an Integral Approach
Publication Year: 2025 Source: Neurogastroenterol Motil PMID: 39962739 DOI: 10.1111/nmo.15021
BACKGROUND: In patients with chronic disorders of the gastrointestinal (GI) system, integral health is disturbed in all dimensions: physical, mental, quality of life, participation, meaningfulness, and daily functioning. In this group, three large subgroups are distinguished: Inflammatory Bowel Diseases (IBD), Hepato-Pancreatico-Biliary diseases (HPB), and NeuroGastroenterology and Motility (NGM) disorders. Our …
Advances in modeling periodontal host-microbe interactions: insights from organotypic and organ-on-chip systems
Publication Year: 2025 Source: Lab Chip PMID: 39963082
Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is driven by an imbalanced interaction between the periodontal microbiota and the host inflammatory response. Beyond its local impact, periodontal disease is associated with systemic conditions such as diabetes mellitus, cardiovascular disease, and inflammatory bowel disease, emphasizing the …
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